Evaluating the Application of Machine Learning in Predicting the Mortality of Hospitalized COVID-19 Patients Using the Confusion Matrix and the Matthews Correlation Coefficient

Archives of Clinical Infectious Diseases, Год журнала: 2025, Номер 20(2)

Опубликована: Янв. 4, 2025

Background: The COVID-19 pandemic, which occurred between 2019 and 2023, posed a significant threat to global health. Its high transmissibility, the emergence of new variants, novel nature disease made treatment control highly challenging. Objectives: This study aimed develop an algorithm for predicting mortality hospitalized patients using machine learning methods. Methods: cross-sectional was conducted on 581 patients. approach integrated multi-model features derived from computed tomography (CT) scans electronic health record (EHR) data. High-resolution (HRCT) images were initially processed Pulmonary Toolkit package in MATLAB software. Subsequently, extracted variables entered into model as predictive factors, alongside demographic characteristics, underlying conditions, laboratory results developed AdaBoost method by incorporating data with HRCT features. Results: In this study, included. Among them, 199 (34.25%) died, while 382 (65.75%) recovered. According algorithm, most effective lymphocyte variables, CRP, age, mean lung density, tissue percentage, RBC count, D-dimer levels, emphysema. MCC Index 0.73, area under ROC curve 0.96. Conclusions: our results, three greatest impact related findings, patient age. Therefore, it is recommended that, given cost HRCT, diagnostic test should only be performed if other risk factors are identified results. If necessary, promptly.

Язык: Английский

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Examining the lifespan of red blood cells in individuals with systemic lupus erythematosus

Clinical Hemorheology and Microcirculation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Objective The objective of this study is to examine the lifespan red blood cells (RBCs) in individuals with systemic lupus erythematosus (SLE), explore factors influencing lifespan, and assess its significance clinical contexts. Methods experimental group comprised 182 patients SLE, while control consisted 90 healthy participants. By using a non-invasive breath test, we measured RBC both groups. Subsequently, conducted comparative analysis general data laboratory findings correlation between SLE various parameters associated characteristics, inflammatory markers, immunological indicators. Furthermore, examined impact COVID-19 infection on among assessed diagnostic efficacy lifespan. Results was notably reduced comparison ( P = 0.002). A positive observed hemoglobin (HB), complement 3, 4, whereas negative noted IgG, erythrocyte sedimentation rate (ESR), C-reactive protein, anti-dsDNA levels (all < 0.05). Noteworthy independent contributors reduction included disease activity presence anemia. While remained unchanged before after > 0.05), post-COVID-19 Also, shorter during active phase compared stable phase, exhibiting even pre-COVID-19 An optimal cutoff for prediction anemia day assessment determined be 93.5 days (AUC 0.792, Conclusion Patients exhibited contrast population, which linked immune as well incidence infection. This discovery holds crucial diagnosis comprehension underlying pathogenic mechanisms within context SLE.

Язык: Английский

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Extracellular Hemoglobin: Modulation of Cellular Functions and Pathophysiological Effects

Biomolecules, Год журнала: 2022, Номер 12(11), С. 1708 - 1708

Опубликована: Ноя. 17, 2022

Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen the tissues. Besides oxygen, hemoglobin within erythrocytes plays an important role in signaling modulation of inflammatory response either directly by binding gas molecules (NO, CO, CO2) or indirectly acting as their source. Once reaches extracellular environment, it acquires several secondary functions affecting surrounding cells By modulating cell functions, this macromolecule becomes involved etiology pathophysiology various diseases. The up-to-date results disclose impact on (i) redox status, (ii) state cells, (iii) proliferation chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance (vi) differentiation. This review pays special attention applied biomedical research use non-vertebrate vertebrate a promising candidate hemoglobin-based carriers, well culture medium additive. Although recent experimental settings have some limitations, they provide additional insight into modulatory activity microenvironments, such stem tumor niches.

Язык: Английский

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Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity

Cytokine, Год журнала: 2024, Номер 177, С. 156545 - 156545

Опубликована: Фев. 17, 2024

Язык: Английский

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New insights into geraniol’s antihemolytic, anti-inflammatory, antioxidant, and anticoagulant potentials using a combined biological and in silico screening strategy

Inflammopharmacology, Год журнала: 2022, Номер 30(5), С. 1811 - 1833

Опубликована: Авг. 6, 2022

Язык: Английский

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Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease

Heliyon, Год журнала: 2024, Номер 10(2), С. e24527 - e24527

Опубликована: Янв. 1, 2024

PurposeThe hematological changes in COVID-19 patients continue to receive great attention, especially the field of public health. To our knowledge, coronavirus disease may be identified based on severity illness, and study peripheral blood smears offer important information facilitate identification. Thus, we evaluated morphological abnormalities (atypical immature lymphocytes, lymphocytes with micronuclei, various nuclear among erythrocytes) quantitative cells 48 individuals disease.MethodsThe present is a retrospective analysis individuals, including 24 hospitalized diagnosed disease. The all were subjected examination identify white red cells. In addition, micronucleus test was conducted assess incidence chromosomal damage lymphocytes. Furthermore, complete count (CBC) performed evaluate cells, particularly differential total leukocyte count, which could indicate immune response against viral infection patients.ResultsThe findings revealed neutrophilia, eosinophilia, mild monocytosis, decreased hematocrit level, elevated erythrocyte sedimentation rate (ESR), leukocytes. It observed that who infected demonstrated thrombocytopenia. indicated presence micronuclei numerous These results help shed light occur patients, potentially contribute development more effective treatments for disease.ConclusionsThe counts (CBCs) conjunction offers potential means identifying impact SARS-CoV-2 hematopoietic systems, thereby providing early indications inflammation. Based study, it has been suggested affect causing alterations establishing corresponding relationship severity.

Язык: Английский

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Characterization and trajectories of hematological parameters prior to severe COVID-19 based on a large-scale prospective health checkup cohort in western China: a longitudinal study of 13-year follow-up

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 7, 2024

The relaxation of the "zero-COVID" policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after infection, while very few studies could track long-term monitoring status and identify characterization hematological parameters prior COVID-19.

Язык: Английский

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Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 30, 2024

This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 an intensive care unit.

Язык: Английский

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Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

Vaccines, Год журнала: 2023, Номер 11(2), С. 218 - 218

Опубликована: Янв. 19, 2023

Myeloid-derived suppressor cells MDSCs are a heterogeneous population of that expand beyond their physiological regulation during pathologies such as cancer, inflammation, bacterial, and viral infections. Their key feature is remarkable ability to suppress T cell natural killer NK responses. Certain risk factors for severe COVID-19 disease, obesity diabetes, associated with oxidative stress. The resulting inflammation stress can negatively impact the host. Similarly, cancer exhibit sustained increase in intrinsic ROS generation maintains oncogenic phenotype drives tumor progression. By disrupting endoplasmic reticulum calcium channels, intracellular accumulation disrupt protein folding ultimately lead proteostasis failure. In COVID-19, consist same two subtypes (PMN-MSDC M-MDSC). While main role polymorphonuclear dampen response cells, they also produce reactive oxygen species nitrogen RNS. We here review origin MDSCs, expansion mechanisms, suppressive functions context presence superoxide anion •O2− ROS.

Язык: Английский

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Evaluation of hematological parameters alterations in different waves of COVID-19 pandemic: A cross-sectional study

PLoS ONE, Год журнала: 2023, Номер 18(8), С. e0290242 - e0290242

Опубликована: Авг. 25, 2023

Background The occurrence of variations in routine hematological parameters is closely associated with disease progression, the development severe illness, and mortality rate among COVID-19 patients. This study aimed to investigate hospitalized patients from 1st 5th waves current pandemic. Methods cross-sectional included a total 1501 laboratory-confirmed based on WHO criteria, who were admitted Shahid Sadoughi Hospital (SSH) Yazd, Iran, February 2020 September 2021. Throughout, we encountered five surge waves. In each wave, randomly selected approximately 300 categorized them infection severity during their hospitalization, including partial recovery, full death. Finally, compared age, gender, pandemic waves, outcomes using Mann-Whitney U Kruskal-Wallis tests. Results mean age (n = 1501) was 61.1±21.88, 816 (54.3%) being men. highest this related third wave 21.3%. There significant difference all parameters, except PDW, PLT, RDW-CV, our population. rise levels MCV RDW-CV occurred 2nd for lymphocyte count, MCHC, PLT RDW-SD, 3rd WBC, RBC, neutrophil MCH, 4th Hb, Hct, ESR ( p < 0.01). median level significantly higher, while lower men than women 0.001). Also, deceased higher those recovered or recovery Conclusion findings unveiled notable across different clinical outcomes. These indicate that behavior strains may differ various stages

Язык: Английский

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