Animals,
Год журнала:
2025,
Номер
15(2), С. 264 - 264
Опубликована: Янв. 18, 2025
Transferrin
Receptor
2
(TfR2)
is
a
homolog
of
1
(TfR1),
involved
in
regulating
intra
and
extracellular
iron
levels.
Altered
pathways
have
been
associated
with
cancer
onset
progression;
however,
their
role
canine
tumors
remains
poorly
explored.
This
study
investigated
TfR2
immunohistochemical
expression
non-neoplastic
testis
for
the
first
time
most
common
types
testicular
tumors:
intratubular
seminomas
(ITSEMs),
diffuse
(DSEMs),
Leydig
cell
(LCTs),
Sertoli
(SCTs).
Immunohistochemical
analysis
revealed
differential
pattern
according
to
tumor
type,
high
observed
ITSEMs
DSEMs,
occasional
LCTs,
absence
SCTs.
These
results
suggest
that
may
play
relevant
seminoma
development.
Furthermore,
specific
highlights
its
potential
as
therapeutic
target,
where
regulation
possible
compensatory
mechanisms
warrant
further
investigation.
International Journal of Peptide Research and Therapeutics,
Год журнала:
2023,
Номер
29(5)
Опубликована: Июль 4, 2023
Abstract
Lactoferrin
(Lf)
is
a
glycoprotein
belonging
to
the
transferrin
family,
which
can
be
found
in
mammalian
milk.
It
was
first
isolated
from
bovine
milk
1930s,
and
later
1960s,
it
determined
human
This
multifunctional
protein
has
specific
ability
bind
iron.
plays
various
biological
roles,
such
as
antibacterial,
antiviral,
antifungal,
anti-tumour,
anti-obesity,
antioxidant,
anti-inflammatory
immunomodulatory
activities.
There
are
several
studies
describing
its
use
against
cancer
cell
lines
(e.g.,
liver,
lung
breast)
even
been
reported
inhibit
development
of
experimental
metastases
mice.
Previous
also
suggest
Lf-mediated
neuroprotection
age-related
neurodegenerative
diseases
expected
attenuate
aging.
More
recently,
Lf
proposed
potential
approach
COVID-19
prophylaxis.
In
this
review,
we
discuss
recent
developments
about
activities
pleiotropic
that
will
reason
exploitation
biomedical
supplementary
nutritional
value.
ACS Bio & Med Chem Au,
Год журнала:
2024,
Номер
4(3), С. 119 - 130
Опубликована: Март 11, 2024
Neurodegeneration
with
brain
iron
accumulation
(NBIA)
is
a
group
of
neurodegenerative
diseases
that
are
typically
caused
by
monogenetic
mutation,
leading
to
development
disordered
movement
symptoms
such
as
dystonia,
hyperreflexia,
etc.
Brain
can
be
diagnosed
through
MRI
imaging
and
hypothesized
the
cause
oxidative
stress,
degeneration
tissue.
There
four
main
types
NBIA:
pantothenate
kinase-associated
neurodegeneration
(PKAN),
PLA2G6-associated
(PLAN),
mitochondrial
membrane
protein-associated
(MKAN),
beta-propeller
(BPAN).
no
causative
therapies
for
these
diseases,
but
chelators
have
been
shown
potential
toward
treating
NBIA.
Three
investigated
in
this
Review:
deferoxamine
(DFO),
desferasirox
(DFS),
deferiprone
(DFP).
DFO
has
treat
Alzheimer's
disease
(AD)
Parkinson's
(PD);
however,
dose-related
toxicity
studies,
well
PKAN
drug
still
requires
more
before
it
applied
NBIA
cases.
Iron
chelation
other
than
ones
currently
clinical
use
not
yet
reached
they
may
possess
characteristics
would
allow
them
access
ways
current
cannot.
Intranasal
formulations
an
attractive
dosage
form
study
therapy,
method
delivery
bypass
blood-brain
barrier
CNS.
Gene
therapy
differs
from
causal
treatment
disease,
whereas
only
target
progression
Because
pathophysiology
unclear,
future
courses
action
should
focused
on
treatment;
best
course
action.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 1053 - 1081
Опубликована: Апрель 1, 2024
Methods:
Related
studies
on
PD
and
ferroptosis
were
searched
in
Web
of
Science
Core
Collection
(WOSCC)
from
inception
to
2023.
VOSviewer,
CiteSpace,
RStudio,
Scimago
Graphica
employed
as
bibliometric
analysis
tools
generate
network
maps
about
the
collaborations
between
authors,
countries,
institutions
visualize
co-occurrence
trends
co-cited
references
keywords.
Results:
A
total
160
original
articles
reviews
related
retrieved,
produced
by
958
authors
162
institutions.
Devos
David
was
most
prolific
author,
with
9
articles.
China
University
Melbourne
had
leading
positions
publication
volume
84
12
publications,
respectively.
Current
hot
topics
focus
excavating
potential
new
targets
for
treating
based
gaining
insight
into
specific
molecular
mechanisms,
including
iron
metabolism
disorders,
lipid
peroxidation,
imbalanced
antioxidant
regulation.
Clinical
aimed
at
targeting
remain
their
preliminary
stages.
Conclusion:
continued
increase
shown
literature
within
field
over
past
decade.
The
current
study
suggested
active
among
Research
pathogenesis
treatment
has
remained
a
prominent
topic
recent
years,
indicating
that
ferroptosis-targeted
therapy
is
approach
halting
progression
PD.
Keywords:
Parkinson's
disease,
ferroptosis,
analysis,
accumulation,
alpha-synuclein,
mitochondrial
dysfunction,
oxidative
stress,
peroxidation
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 595 - 595
Опубликована: Март 6, 2024
Iron
is
the
micronutrient
with
best-studied
biological
functions.
It
widely
distributed
in
nature,
and
its
involvement
main
metabolic
pathways
determines
great
importance
of
this
metal
for
all
organisms.
required
cellular
respiration
various
biochemical
processes
that
ensure
proper
functioning
cells
organs
human
body,
including
brain.
also
plays
an
important
role
production
free
radicals,
which
can
be
beneficial
or
harmful
to
under
conditions.
Reviews
iron
metabolism
regulation
found
literature,
further
advances
understanding
molecular
basis
are
being
made
every
year.
The
aim
review
systematise
available
data
on
function
nervous
system,
especially
summarises
recent
views
regulatory
mechanisms
humans,
essential
action
hepcidin.
Special
attention
given
absorption
small
intestine
purpose
but
critically
pool
Bioinorganic Chemistry and Applications,
Год журнала:
2022,
Номер
2022(1)
Опубликована: Янв. 1, 2022
Solid
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
hypoxia,
low
acidity,
and
high
hydrogen
peroxide
glutathione
(GSH)
levels,
among
others.
These
factors,
offer
favourable
microenvironments
nourishment
for
development
spread,
also
serve
as
gateway
specific
successful
cancer
therapies.
A
good
example
is
metal
structures
been
synthesized
utilized
to
enhance
oxygen
supply
they
shown
great
promise
in
the
alleviation
of
hypoxia.
In
hypoxic
environment,
certain
oxygen‐dependent
treatments
such
photodynamic
therapy
radiotherapy
fail
respond
therefore
modulating
has
found
antitumor
impact
drugs.
Under
acidic
environments,
produced
by
reaction
peroxides
with
water
not
only
induces
oxidative
stress
but
produces
additional
oxygen.
This
achieved
since
acts
reactive
substrate
molecules
catalyse
enzymes,
alleviating
hypoxia
observed
microenvironment.
Metal
ions
released
process
can
distinct
bioactivity
their
own
right.
used
anticancer
are
rapidly
evolving
field,
there
evidence
that
option
regulating
therapy.
this
regard,
synthesis
mechanisms
behind
application
specifically
target
highlighted
review.
Various
characteristics
TME
angiogenesis,
inflammation,
acidity
ion
homeostasis
addressed
together
forms
synergistic
combination
treatments.
Brain Sciences,
Год журнала:
2023,
Номер
13(3), С. 500 - 500
Опубликована: Март 16, 2023
Advancements
in
modern
medicine
have
improved
the
quality
of
life
across
globe
and
increased
average
lifespan
our
population
by
multiple
decades.
Current
estimates
predict
2030,
12%
global
will
reach
a
geriatric
age
live
another
3-4
This
swelling
place
critical
stress
on
healthcare
infrastructures
due
to
accompanying
increases
age-related
diseases
comorbidities.
While
much
research
focused
long-lived
individuals
seeks
answer
questions
regarding
how
healthier,
there
is
deficit
investigating
what
aspects
lives
accelerate
or
exacerbate
aging.
In
particular,
heavy
metals
are
recognized
as
significant
threat
human
health
with
links
plethora
diseases,
widespread
exposures
from
occupational,
medical,
environmental
settings.
We
believe
ought
be
classified
class
gerontogens
(i.e.,
chemicals
that
biological
aging
cells
tissues).
Gerontogens
may
best
studied
through
their
effects
"Hallmarks
Aging",
nine
physiological
hallmarks
demonstrated
occur
aged
cells,
tissues,
bodies.
Evidence
suggests
cellular
senescence-a
permanent
growth
arrest
cells-is
one
most
pertinent
useful
indicator
tissues.
Here,
we
discuss
roles
brain
briefly
general,
then
expand
upon
observations
for
contributing
neurodegenerative
disorders.
particularly
emphasize
senescence
diseases.
Finally,
inducing
senescence.
The
glaring
lack
knowledge
about
gerontogenic
mechanisms
necessitates
greater
field,
especially
context
crisis.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
The
literature
on
the
relationships
among
blood
iron
levels,
cognitive
performance,
and
brain
levels
specific
to
women
at
menopausal
transition
is
ambiguous
best.
need
better
understand
these
potential
in
for
whom
monthly
loss
(and
thus
loss)
ceasing
highlighted
by
fact
that
accumulates
tissue
over
time
accumulation
thought
be
a
factor
development
of
neurodegenerative
disease.
Non-anemic
who
were
either
low
or
had
normal
their
age
race/ethnicity
provided
samples,
underwent
MRI
scans
estimate
performed
set
tasks
with
concurrent
EEG.
Results:
Cognitive
performance
as
well
dynamics
positively
related
including
measures
associated
oxygen
transport.
There
no
between
any
iron.
Higher
status
was
sample
neither
deficient
nor
anemic,
without
there
being
indication
higher
systemic
brain.
Consequently,
addressing
may
candidate
approach
alleviating
"brain
fog"
commonly
experienced
menopause.
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 745 - 745
Опубликована: Фев. 20, 2025
The
literature
on
the
relationships
among
blood
iron
levels,
cognitive
performance,
and
brain
levels
specific
to
women
at
menopausal
transition
is
ambiguous
best.
need
better
understand
these
potential
in
for
whom
monthly
loss
(and
thus
loss)
ceasing
highlighted
by
iron's
accumulation
tissue
over
time,
thought
be
a
factor
development
of
neurodegenerative
disease.
Non-anemic
who
were
either
low
or
had
normal
their
age
race/ethnicity
provided
samples,
underwent
MRI
scans
estimate
performed
set
tasks
with
concurrent
EEG.
Cognitive
performance
dynamics
positively
related
including
measures
associated
oxygen
transport.
There
no
between
any
iron.
Higher
status
was
sample
neither
deficient
nor
anemic,
without
there
being
indication
that
higher
systemic
Consequently,
addressing
may
candidate
approach
alleviating
"brain
fog"
commonly
experienced
menopause.
