Drugs and Drug Candidates,
Год журнала:
2024,
Номер
3(4), С. 813 - 837
Опубликована: Ноя. 25, 2024
Breast
cancer
(BC)
is
the
most
prevalent
form
of
malignancy
among
women
on
a
global
scale,
ranking
alongside
lung
cancer.
Presently,
conventional
approaches
to
treatment
include
surgical
procedures
followed
by
chemotherapy
or
radiotherapy.
Nonetheless,
efficacy
these
treatments
in
battling
BC
often
compromised
due
adverse
effects
they
inflict
healthy
tissues
and
organs.
In
recent
times,
range
nanoparticles
(NPs)
has
emerged,
exhibiting
potential
specifically
target
malignant
cells
while
sparing
normal
organs
from
harm.
This
paved
way
for
development
nanoparticle-mediated
targeted
drug
delivery
systems,
holding
great
promise
as
technique
addressing
BC.
To
increase
this
new
method,
several
nanocarriers
including
inorganic
NPs
(such
magnetic
NPs,
silica
etc.)
organic
(e.g.,
dendrimers,
liposomes,
micelles,
polymeric
NPs)
have
been
used.
Herein,
we
discuss
mechanism
NP-targeted
advancement
therapeutic
strategies
anticancer
We
also
future
prospects
challenges
nanoparticle-based
therapies
Pharmaceuticals,
Год журнала:
2023,
Номер
16(3), С. 433 - 433
Опубликована: Март 12, 2023
Various
formulations
of
polymeric
micelles,
tiny
spherical
structures
made
materials,
are
currently
being
investigated
in
preclinical
and
clinical
settings
for
their
potential
as
nanomedicines.
They
target
specific
tissues
prolong
circulation
the
body,
making
them
promising
cancer
treatment
options.
This
review
focuses
on
different
types
materials
available
to
synthesize
well
ways
that
micelles
can
be
tailored
responsive
stimuli.
The
selection
stimuli-sensitive
polymers
used
micelle
preparation
is
based
conditions
found
tumor
microenvironment.
Additionally,
trends
using
treat
presented,
including
what
happens
after
they
administered.
Finally,
various
drug
delivery
applications
involving
discussed
along
with
regulatory
aspects
future
outlooks.
As
part
this
discussion,
we
will
examine
current
research
development
field.
challenges
barriers
may
have
overcome
before
widely
adopted
clinics
also
discussed.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(2), С. 195 - 195
Опубликована: Фев. 1, 2024
Hypoxia-inducible
factor-1
(HIF-1)
is
a
key
regulator
for
balancing
oxygen
in
the
cells.
It
transcription
factor
that
regulates
expression
of
target
genes
involved
homeostasis
response
to
hypoxia.
Recently,
research
has
demonstrated
multiple
roles
HIF-1
pathophysiology
various
diseases,
including
cancer.
crucial
mediator
hypoxic
and
metabolism,
thus
contributing
tumor
development
progression.
Studies
showed
HIF-1α
subunit
significantly
upregulated
cancer
cells
promotes
survival
by
mechanisms.
In
addition,
potential
progression,
cell
division,
survival,
proliferation,
angiogenesis,
metastasis.
Moreover,
role
regulating
cellular
metabolic
pathways,
particularly
anaerobic
metabolism
glucose.
Given
its
significant
it
been
an
intriguing
therapeutic
research.
Several
compounds
targeting
HIF-1-associated
processes
are
now
being
used
treat
different
types
This
review
outlines
emerging
strategies
as
well
relevance
regulation
pathways
addresses
employment
nanotechnology
developing
these
promising
strategies.
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1255 - 1255
Опубликована: Июнь 11, 2023
Genetic,
developmental,
biochemical,
and
environmental
variables
interact
intricately
to
produce
sex
differences.
The
significance
of
differences
in
cancer
susceptibility
is
being
clarified
by
numerous
studies.
Epidemiological
research
registries
have
revealed
over
the
past
few
years
that
there
are
definite
variations
incidence,
progression,
survival.
However,
oxidative
stress
mitochondrial
dysfunction
also
a
significant
impact
on
response
treatment
neoplastic
diseases.
Young
women
may
be
more
protected
from
than
men
because
most
proteins
implicated
regulation
redox
state
function
under
control
sexual
hormones.
In
this
review,
we
describe
how
hormones
activity
antioxidant
enzymes
mitochondria,
as
well
they
affect
several
molecular
pathways
underlie
gender-related
discrepancies
been
identified
better
understood,
which
lead
effective
precision
medicine
vital
information
options
for
both
males
females
with
illnesses.
Abstract
Nanozyme‐mediated
chemodynamic
therapy
has
emerged
as
a
promising
strategy
due
to
its
tumor
specificity
and
controlled
catalytic
activity.
However,
the
poor
efficacy
caused
by
low
hydrogen
peroxide
(H
2
O
)
levels
in
microenvironment
(TME)
poses
challenges.
Herein,
an
H
self‐supplying
nanozyme
is
constructed
through
loading
peroxide‐like
active
platinum
nanoparticles
(Pt
NPs)
on
zinc
(ZnO
(denoted
ZnO
@Pt).
releases
response
acidic
TME.
Pt
NPs
catalyze
hydroxyl
radical
generation
from
while
reducing
mitigation
of
oxidative
stress
glutathione,
serving
reactive
oxygen
(ROS)
amplifier
self‐cascade
catalysis.
In
addition,
Zn
2+
released
interferes
with
cell
energy
supply
metabolism,
enabling
ion
interference
synergize
therapy.
vitro
studies
demonstrate
that
@Pt
induces
cellular
injury
enhanced
ROS
release,
downregulating
ATP
NAD
+
levels.
vivo
assessment
anticancer
effects
showed
could
generate
at
sites
induce
apoptosis
downregulate
pathways
associated
glycolysis,
resulting
89.7%
reduction
growth.
This
study
presents
TME‐responsive
capable
self‐supply
therapy,
providing
paradigm
for
tumor‐specific
design.
Cancers,
Год журнала:
2024,
Номер
16(12), С. 2171 - 2171
Опубликована: Июнь 7, 2024
Cancer
cells
show
altered
antioxidant
defense
systems,
dysregulated
redox
signaling,
and
increased
generation
of
reactive
oxygen
species
(ROS).
Targeting
cancer
through
ROS-mediated
mechanisms
has
emerged
as
a
significant
therapeutic
strategy
due
to
its
implications
in
progression,
survival,
resistance.
Extensive
research
focused
on
selective
H2O2
for
cell
killing
by
employing
various
strategies
such
metal-based
prodrugs,
photodynamic
therapy,
enzyme-based
nano-particle
mediated
approaches,
chemical
modulators,
combination
therapies.
Many
these
H2O2-amplifying
approaches
have
demonstrated
promising
anticancer
effects
selectivity
preclinical
investigations.
They
selectively
induce
cytotoxicity
while
sparing
normal
cells,
sensitize
resistant
modulate
the
tumor
microenvironment.
However,
challenges
remain
achieving
selectivity,
addressing
heterogeneity,
ensuring
efficient
delivery,
managing
safety
toxicity.
To
address
those
issues,
H2O2-generating
agents
been
combined
with
other
treatments
leading
optimized
This
review
focuses
agents/approaches
that
kill
via
H2O2-mediated
mechanisms.
Different
categories
compounds
generate
are
summarized,
their
underlying
function
elucidated,
clinical
studies
well
recent
advancements
discussed,
prospects
targeted
utility
explored.
By
understanding
potential
compounds,
researchers
can
pave
way
development
effective
personalized
treatments.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 27, 2023
Malignant
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
mild
acidity,
hypoxia,
overexpressed
reactive
oxygen
species
(ROS),
and
high
glutathione
(GSH)
levels,
among
others.
Recently,
TME
regulation
approaches
attracted
widespread
attention
in
cancer
immunotherapy.
Nanoparticles
as
drug
delivery
systems
ability
to
modulate
the
hydrophilicity
of
drugs
affect
uptake
efflux
tumor.
Especially,
metal
nanoparticles
been
extensive
applied
for
immunotherapy
due
their
physical
properties
elaborate
design.
However,
potential
deficiencies
low
biodegradability,
toxicity
treatment
side
effects
restrict
clinical
application.
In
this
review,
we
briefly
introduce
feature
characteristics
recent
advances
responsive
addition,
could
be
combined
with
other
treatments,
such
chemotherapy,
radiotherapy
photodynamic
therapy
also
is
presented.
Finally,
challenges
outlook
improving
antitumor
efficiency,
effect
risks
has
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(6), С. 6689 - 6708
Опубликована: Фев. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
