Pesticide pollution in argentine drinking water: A call to ensure safe access

Environmental Challenges, Год журнала: 2023, Номер 14, С. 100808 - 100808

Опубликована: Дек. 5, 2023

The application of pesticides in Argentina has been on the rise since 2000. However, monitoring drinking water lacks regular updates. This research study analysed 53 and degradation products to evaluate their presence water. most frequently detected were atrazine, metolachlor, imidacloprid, hydroxyatrazine, imazethapyr 2.4D. During sample collection period, 25% soil was planted with winter crops, while just under 50% allocated summer especially corn soybeans. correlation between used these crops those found significant/notable. As a matter fact, individual concentration [25] exceeded European limit 8.7% 17.6% samples collected from public private supplies, respectively, cumulative 4.3% 13.9% respectively. Based findings, we recommend/propose inclusion within regulatory framework that governs quality control guarantee protection health progressively reduce use Argentine agricultural system. Adopting measures will contribute ensuring safety sustainability sources for population.

Язык: Английский

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Pesticides, cancer, and oxidative stress: an application of machine learning to NHANES data

Environmental Sciences Europe, Год журнала: 2024, Номер 36(1)

Опубликована: Янв. 8, 2024

Abstract Background The large-scale application of pyrethroids and organophosphorus pesticides has great benefits for pest control. However, the increase cancer incidence rate in recent years also caused public concern about health risks pesticides. Hence, we utilized data from National Health Nutrition Examination Survey (NHANES) to assess association risk between pesticide exposure several cancers, along with comprehensive impact oxidative stress. In this study, six cancers common were included analyze their correlation risk. And levels eight stress marks two inflammatory markers used stratified analysis. Multiple logistic regression analysis was applied estimate odds ratio 95% confidence intervals. Machine learning prediction models established evaluate importance different factors. Results According analyzed, each increased three four out on average. Iron, aspartate aminotransferase (AST), gamma glutamyl transferase positively correlated most cases exposure. Except demographic factors, factors such as AST, iron, 3-phenoxybenzoic acid showed high contributions random forest model, which consistent our expectations. receiver operating characteristic curve that model had sufficient accuracy (74.2%). Conclusion Our results indicated specific cancer, may be mediated by various mechanisms. Additionally, some biochemical indicators have potential screened prevention.

Язык: Английский

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Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner

The Science of The Total Environment, Год журнала: 2022, Номер 864, С. 161054 - 161054

Опубликована: Дек. 21, 2022

Язык: Английский

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Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Сен. 14, 2023

Studies have documented the high occurrence of several tumors, including female breast cancer, in populations occupationally exposed to pesticides worldwide. It is believed that addition direct DNA damage, other molecular alterations indicate genomic instability are associated, such as epigenetic modifications and production inflammation mediators. The present study characterized profile inflammatory changes tissue women without cancer pesticides. In samples normal collected during biopsy evaluated negative for by a pathologist, oxidative stress levels were assessed markers through measurements lipoperoxides total antioxidant capacity sample (TRAP) high-sensitivity chemiluminescence, well nitric oxide (NOx) metabolites. inflammation-modulating transcription factors PPAR-γ (peroxisome proliferator-activated receptor gamma) NF-κB (nuclear factor kappa B) also quantified, pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) interleukin 12 (IL-12). lipoperoxides, TRAP, NOx significantly lower group. On hand, increased women, with no variation NF-κB. There was rise TNF-α significant variations IL-12 levels. These findings suggest an signature associated pesticide exposure, which may trigger mechanisms related mutations carcinogenesis.

Язык: Английский

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Risk of breast cancer in daughters of agricultural workers in Denmark

Environmental Research, Год журнала: 2023, Номер 240, С. 117374 - 117374

Опубликована: Окт. 20, 2023

Язык: Английский

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Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 24, 2023

Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined circulating cytokine profile Th1/Th2/Th17 patterns women occupationally pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working cancer, or not pesticides, quantify levels cytokines IL-1β, IL-12, IL-4, IL-17-A, TNF -α. Data disease clinical outcomes through medical follow-up. IL-12 was reduced tumors larger than 2 cm those lymph node metastases. Significantly IL-17A observed patients Luminal B subtype tumors, high ki67 proliferation rates, histological grade, positive for progesterone receptor. Reduced IL-4 also seen invasion. Our data show that occupational exposure induces significant changes necessary tumor control correlates poor

Язык: Английский

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A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9790 - 9790

Опубликована: Июнь 6, 2023

Endocrine-disrupting chemicals (EDCs) are chemicals, either natural or synthetic, that can interfere with the production, distribution, function, metabolism, excretion of hormones in our body [...].

Язык: Английский

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Effects of Dichlorodiphenyltrichloroethane on Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review

Опубликована: Июль 27, 2023

Persistent Organic Pollutants (POP) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found detectable amounts organisms even after its use was banned 1970s. Studies show that exposure can cause adverse health effects humans animals, impairing fertility increasing risk of developing cancer. The aim this work provide comprehensive overview available literature on effect metabolites female reproductive tract, leading infertility Medline Google Scholar were systematically searched detect all relevant animal human studies published last 20 years (January 2003 February 2023) accordance with Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) statement. In total, 38 included qualitative synthesis. This systematic search review indicated associated decline acts sufficient carcinogen instigating cancers.

Язык: Английский

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Epigenetic aging of mammalian gametes

Molecular Reproduction and Development, Год журнала: 2023, Номер 90(12), С. 785 - 803

Опубликована: Ноя. 24, 2023

Abstract The process of aging refers to physiological changes that occur an organism as time progresses and involves DNA, proteins, metabolism, cells, organs. Like the rest cells in body, gametes age, it is well established there a decline reproductive capabilities females males with aging. One major pathways known be involved epigenetic changes. epigenome multitude chemical modifications performed on DNA chromatin affect ability transcribed. In this review, we explore effects female male focus throughout Quality oocytes occurs at relatively early age. Epigenetic constitute important part oocyte methylation reduced along expression methyltransferases (DNMTs). Histone deacetylases (HDAC) also reduced, loss heterochromatin marks As consequence loss, retrotransposon elevated, aged suffer from damage. sperm, affects sperm number, motility fecundity, may process. 5 methyl‐cytosine (5mC) elevated men, but Long interspersed nuclear elements (LINE) reduced. Di trimethylation histone 3 lysine 9 (H3K9me2/3) men 27 (H3K27me3) elevated. protamine makeup changed, misbalanced ratio between proteins P1 P2. study recently gaining interest. current status field suggests many aspects gamete are still open for investigation. clinical applications these investigations have far‐reaching consequences fertility sociological human behavior.

Язык: Английский

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Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish

Biology Open, Год журнала: 2024, Номер 13(3)

Опубликована: Март 1, 2024

ABSTRACT The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on human and fish health are well characterized several lines evidence suggest that some can manifest years after cessation. Using a developmental protocol whereby zebrafish embryos were exposed 0.5 1.5 mM iAs from 4–120 hours post fertilization (hpf) then removed, we investigated sustained effects gene expression in liver, survival, reproductive success, susceptibility toxicity subsequent generation. Persistent during development had substantial hepatic transcriptome, with 23% all expressed genes significantly changed following exposure. gsto2 is involved metabolism this was downregulated female livers 9 months removed. Developmental iAs, but not mM, decreased survival by over 50% at 3 age. Adults developmentally reduced mating their offspring no differences observable aspects or toxicity. This demonstrates reduces long-term success causes changes liver.

Язык: Английский

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