Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 11, 2024
Abstract
Huntington’s
disease
(HD)
is
a
neurological
disorder
caused
by
CAG
expansion
in
the
Huntingtin
gene
(
HTT
).
HD
pathology
mostly
affects
striatal
medium-sized
spiny
neurons
and
results
an
altered
cortico-striatal
function.
Recent
studies
report
that
motor
skill
learning,
stimulation
attenuate
neuropathology
HD,
resulting
amelioration
of
some
cognitive
functions.
During
physical
training,
extracellular
vesicles
(EVs)
are
released
many
tissues,
including
brain,
as
potential
means
for
inter-tissue
communication.
To
investigate
how
involving
acute
modulates
EVs
crosstalk
between
cells
striatum,
we
trained
wild-type
(WT)
R6/1
mice,
latter
with
deficits,
on
accelerating
rotarod
test,
isolated
their
EVs.
from
mice
presented
alterations
small
exosome
population
when
compared
to
WT.
Proteomic
analyses
revealed
recapitulated
signaling
energy
deficiencies
present
HD.
Motor
learning
restored
amount
protein
content
comparison
naïve
mice.
Furthermore,
modulated
crucial
pathways
metabolism
neurodegeneration.
All
these
data
provide
new
insights
into
pathogenesis
put
spotlight
understand
metabolic
neurodegenerative
diseases.
Moreover,
our
suggest
modulator
cell-to-cell
communication
striatum.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(6), С. 5999 - 6017
Опубликована: Июнь 14, 2024
Amyotrophic
lateral
sclerosis
(ALS)
represents
a
neurodegenerative
disorder
characterized
by
the
progressive
loss
of
both
upper
and
lower
motor
neurons,
resulting
in
muscular
atrophy
eventual
paralysis.
While
much
research
has
concentrated
on
investigating
impact
major
mutations
associated
with
ALS
neurons
central
nervous
system
(CNS)
cells,
recent
studies
have
unveiled
that
pathogenesis
extends
beyond
CNS
imbalances,
encompassing
dysregulation
other
tissues
such
as
skeletal
muscle.
Evidence
from
animal
models
patients
supports
this
broader
perspective.
Skeletal
muscle,
once
considered
solely
an
effector
organ,
is
now
recognized
possessing
significant
secretory
activity
capable
influencing
neuron
survival.
However,
precise
cellular
molecular
mechanisms
underlying
detrimental
effects
observed
muscle
its
structures
remain
poorly
understood.
Additionally,
emerging
data
suggest
extracellular
vesicles
(EVs)
may
play
role
establishment
function
neuromuscular
junction
(NMJ)
under
physiological
pathological
conditions
wasting
regeneration
muscles,
particularly
diseases
like
ALS.
This
review
aims
to
explore
key
findings
about
involvement
ALS,
shedding
light
potential
contributions
EVs
their
possible
application
for
design
biosensors.
Frontiers in Molecular Biosciences,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 16, 2022
RNA
is
a
vital
biomolecule,
the
function
of
which
tightly
spatiotemporally
regulated.
organelles
are
biological
structures
that
either
membrane-less
or
surrounded
by
membrane.
They
produced
all
cells
and
indulge
in
cellular
mechanisms.
include
intracellular
granules
extracellular
exosomes.
play
an
essential
role
regulation
localization,
stability
translation.
Aberrant
connected
to
disease
development.
For
example,
microsatellite
diseases
such
as
CXG
repeat
expansion
disorders,
mutant
RNA’s
localization
affected.
not
only
transported
intracellularly
but
can
also
be
between
via
The
loading
exosomes
regulated
RNA-protein
complexes,
recent
studies
show
cytosolic
share
common
content.
Intracellular
exosome
may
therefore
related.
Exosomes
transfer
pathogenic
molecules
from
cell
cell,
thereby
driving
progression.
Both
vesicles
serve
source
for
diagnostic
treatment
strategies.
In
therapeutic
approaches,
pharmaceutical
agents
loaded
into
then
transport
them
desired
cells/tissues.
This
promising
target
specific
strategy
with
few
side
effects.
With
respect
diagnostics,
disease-specific
content
exosomes,
e.g.,
RNA-signatures,
attractive
biomarker
central
nervous
system
detecting
early
physiological
disturbances,
even
before
symptoms
neurodegeneration
appear
irreparable
damage
occurs.
this
review,
we
summarize
known
cytoplasmic
vesicles,
well
their
dysfunction
disorders.
We
provide
summary
established
protocols
isolation
characterization
both
organelles.
Exploration of Medicine,
Год журнала:
2022,
Номер
2(3), С. 468 - 478
Опубликована: Окт. 27, 2022
Inflammatory
bowel
disease
(IBD)
is
a
multifactorial
chronic
disease.
Patients
with
IBD
have
an
increased
risk
of
developing
colorectal
cancer
which
has
become
major
health
concern.
might
exert
role
engrams
for
making
the
condition
specific
inflammation
in
gut.
Dysregulation
immune
cells
induced
by
command
be
crucial
pathogenesis
damages
gut
epithelium.
The
anti-proliferative
(APRO)
family
proteins
characterized
immediate
early
responsive
gene-products
that
involved
machinery
carcinogenesis
IBD.
Herein,
it
suggested
some
probiotics
bacteria
could
prevent
development
and/or
progression
related
tumors.
In
addition,
consideration
regarding
application
studying
APRO
comprehension
tumors
been
presented.
It
hypothesized
overexpression
Tob1,
member
proteins,
epithelium
suppress
function
adjacent
cytotoxic
possibly
via
paracrine
signaling.
Veterinary Sciences,
Год журнала:
2024,
Номер
11(5), С. 187 - 187
Опубликована: Апрель 25, 2024
Canine
mesenchymal
stromal
cells
(MSCs)
possess
the
capacity
to
differentiate
into
a
variety
of
cell
types
and
secrete
wide
range
bioactive
molecules
in
form
soluble
membrane-bound
exosomes.
Extracellular
vesicles/exosomes
are
nano-sized
vesicles
that
carry
proteins,
lipids,
nucleic
acids
can
modulate
recipient
response
various
ways.
The
process
exosome
formation
is
physiological
interaction
between
cells.
With
significant
increase
basic
research
over
last
two
decades,
there
has
been
tremendous
expansion
MSC
exosomes
their
potential
applications
canine
disease
models.
characterization
demonstrated
considerable
variations
terms
source,
culture
conditions
MSCs,
inclusion
fetal
bovine
serum
or
platelet
lysate
cultures.
Furthermore,
amalgamation
with
nano-materials
become
novel
approach
fabrication
nano-exosomes.
necessitates
elimination
extrinsic
thus
enhancing
therapeutic
uses
models,
including
spinal
cord
injury,
osteoarthritis,
inflammatory
bowel
disease.
This
review
summarizes
current
knowledge
on
characteristics,
biological
functions,
clinical
relevance
use
human
research.
As
discussed,
have
ability
control
lethal
vertebrate
diseases
by
administration
directly
at
injury
site
through
specific
drug
delivery
mechanisms.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 11, 2024
Abstract
Huntington’s
disease
(HD)
is
a
neurological
disorder
caused
by
CAG
expansion
in
the
Huntingtin
gene
(
HTT
).
HD
pathology
mostly
affects
striatal
medium-sized
spiny
neurons
and
results
an
altered
cortico-striatal
function.
Recent
studies
report
that
motor
skill
learning,
stimulation
attenuate
neuropathology
HD,
resulting
amelioration
of
some
cognitive
functions.
During
physical
training,
extracellular
vesicles
(EVs)
are
released
many
tissues,
including
brain,
as
potential
means
for
inter-tissue
communication.
To
investigate
how
involving
acute
modulates
EVs
crosstalk
between
cells
striatum,
we
trained
wild-type
(WT)
R6/1
mice,
latter
with
deficits,
on
accelerating
rotarod
test,
isolated
their
EVs.
from
mice
presented
alterations
small
exosome
population
when
compared
to
WT.
Proteomic
analyses
revealed
recapitulated
signaling
energy
deficiencies
present
HD.
Motor
learning
restored
amount
protein
content
comparison
naïve
mice.
Furthermore,
modulated
crucial
pathways
metabolism
neurodegeneration.
All
these
data
provide
new
insights
into
pathogenesis
put
spotlight
understand
metabolic
neurodegenerative
diseases.
Moreover,
our
suggest
modulator
cell-to-cell
communication
striatum.
