Plant Growth Regulation,
Год журнала:
2024,
Номер
104(1), С. 233 - 251
Опубликована: Май 23, 2024
Abstract
Flaxseed
(
Linum
usitatissimum
L.)
is
renowned
for
having
the
highest
concentration
of
lignans
among
all
plant
species
worldwide.
However,
it
also
contains
a
notable
amount
cyanogenic
glycosides,
prompting
efforts
to
reduce
their
levels.
MicroRNAs,
recognized
as
significant
epigenetic
factors,
hold
potential
serve
genetic
markers
in
achieving
this
breeding
goal.
In
study,
44,885
mature
microRNAs
were
utilized
alongside
one
genome
and
four
transcriptomes
flax.
Twelve
gene
sequences
obtained
five
lignan
enzymes
three
related
glycosides.
Based
on
our
silico
approach,
we
identified
15
microRNA
families
metabolic
pathway,
10
glycoside
6
regulating
both
pathways.
Additionally,
contributed
annotation
used
verified
functionality
“Finding
genes
by
keyword”
algorithm
available
Phytozome
13.
The
results
led
design
unique
schema
mediated
regulation
biosynthetic
pathways
This
research
will
enhance
understanding
regulatory
mechanisms
these
pathways,
along
with
other
specialized
metabolites.
predicted
can
be
employed
marker-assisted
selection
objective
optimizing
ratio
nutritional
antinutritional
components
flaxseed
while
maintaining
current
physiological
parameters.
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 860 - 860
Опубликована: Апрель 2, 2023
It
is
more
effective
to
maintain
good
health
than
regain
it
after
losing
it.
This
work
focuses
on
the
biochemical
defense
mechanisms
against
free
radicals
and
their
role
in
building
maintaining
antioxidant
shields,
aiming
show
how
balance,
as
much
possible,
situations
which
we
are
exposed
radicals.
To
achieve
this
aim,
foods,
fruits,
marine
algae
with
a
high
content
should
constitute
basis
of
nutritional
elements,
since
natural
products
known
have
significantly
greater
assimilation
efficiency.
review
also
gives
perspective
use
antioxidants
can
extend
life
food
products,
by
protecting
them
from
damage
caused
oxidation
well
additives.
Flaxseed,
a
rich
source
of
omega-3
polyunsaturated
fatty
acid
alpha-linolenic
(ALA),
lignans,
and
soluble
fiber,
has
attracted
attention
for
its
potential
to
improve
multiple
cardiometabolic
risk
factors.
While
benefits
are
well-recognized,
comprehensive
evaluations
direct
impact
on
clinical
outcomes,
such
as
the
prevention
or
progression
diseases,
remain
limited.
Additionally,
support
healthy
aging
longevity
through
fundamental
biological
mechanisms
not
been
fully
elucidated.
This
review
synthesizes
existing
research
flaxseed
supplementation,
highlighting
effects
factors
underlying
mechanisms,
broader
implications
health
promotion
aging.
Findings
demonstrate
that
supplementation
significantly
improves
several
factors,
including
body
weight,
mass
index,
lipid
levels,
blood
pressure,
glycemic
measures,
markers
inflammation
(e.g.,
C-reactive
protein
interleukin-6),
oxidative
stress,
liver
enzymes.
Blood
pressure
reductions
range
from
approximately
2
15
mmHg
systolic
1
7
diastolic
with
magnitude
influenced
by
dose,
duration,
baseline
profiles.
evidence
linking
hypertension,
metabolic
syndrome,
dysfunction-associated
steatotic
disease,
type
diabetes,
chronic
kidney
cardiovascular
disease
is
limited,
bioactive
components-ALA,
fiber-are
strongly
associated
reduced
risks
these
conditions.
The
mediated
pathways,
anti-inflammatory
antioxidant
effects,
improved
glucose
metabolism
insulin
sensitivity,
modulation
gut
microbiota,
enhanced
vascular
health.
Beyond
may
influence
key
processes
relevant
aging,
underscoring
promote
longevity.
Optimal
appear
be
achieved
ground
whole
at
doses
≥
30
g/day
least
12
weeks,
particularly
among
individuals
high
risk.
Future
should
focus
elucidating
flaxseed's
action,
clarifying
role
in
prevention,
refining
dietary
recommendations
harness
interventions.
Frontiers in Nutrition,
Год журнала:
2023,
Номер
10
Опубликована: Июль 20, 2023
Ulcerative
colitis
(UC)
is
presently
considered
a
multifactorial
pathology,
which
may
lead
to
persistent
inflammatory
action
of
the
gastrointestinal
tract
(GIT)
because
an
improperly
managed
immunological
reactivity
intestinal
microbiota
found
in
GIT.
The
immune
response
common
commensal
microbes
plays
essential
role
inflammation
related
UC
synbiotics,
and
it
important
element
optimal
therapy
UC.
Therefore,
i.e.,
mixture
prebiotics
probiotics,
help
control
diseased
state.
Synbiotics
alleviate
colon
by
lowering
reactive
oxygen
species
(ROS)
improving
level
antioxidant
enzymes
such
as
catalase
(CAT),
glutathione
peroxidase
(GPX),
superoxide
dismutase
(SOD).
Prebiotic
supplementation
not
practice
at
moment,
despite
numerous
research
findings
proving
that
benefits
both
probiotics
encourage
their
continued
existence
positioning
GIT,
with
positive
effects
on
human
health
managing
response.
However,
fact
there
have
been
fewer
studies
treatment
different
coupled
selected
prebiotics,
outcomes
these
very
favorable.
This
evidence-based
study
explores
possible
ROS,
SOD,
synbiotics
proposed
review
also
focuses
alteration
gut
microbiota,
defense
tract,
management
Thus,
current
article
emphasizes
oxidative
stress
signaling
GI
stress-based
pathomechanisms
patients,
therapies
inhibiting
stress’
effects.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 27, 2023
Aging
is
an
inevitable
process
influenced
by
genetics,
lifestyles,
and
environments.
With
the
rapid
social
economic
development
in
recent
decades,
proportion
of
elderly
has
increased
rapidly
worldwide,
many
aging-related
diseases
have
shown
upward
trend,
including
nervous
system
diseases,
cardiovascular
metabolic
cancer.
The
rising
burden
become
urgent
global
health
challenge
requires
immediate
attention
solutions.
Natural
products
been
used
for
a
long
time
to
treat
various
human
diseases.
primary
cellular
pathways
that
mediate
longevity-extending
effects
natural
involve
nutrient-sensing
pathways.
Among
them,
sirtuin,
AMP-activated
protein
kinase,
mammalian
target
rapamycin,
p53,
insulin/insulin-like
growth
factor-1
signaling
are
most
widely
studied.
Several
studies
reviewed
individual
compounds
on
aging
along
with
underlying
mechanisms.
from
food
sources,
such
as
polyphenols,
saponins,
alkaloids,
polysaccharides,
classified
antiaging
promote
prolong
life
via
In
this
article,
we
several
recently
identified
potential
properties
highlighted
their
molecular
discovery
use
dietary
supplements
can
prevent
multiple
humans
will
be
beneficial.
Thus,
review
provides
theoretical
background
existing
agents.
Molecules,
Год журнала:
2023,
Номер
28(1), С. 343 - 343
Опубликована: Янв. 1, 2023
Lignans
are
non-flavonoid
polyphenols
present
in
a
wide
range
of
foods
frequently
consumed
the
Western
world,
such
as
seeds,
vegetables
and
fruits,
beverages
coffee,
tea
wine.
In
particular,
human
gut
microbiota
(GM)
can
convert
dietary
lignans
into
biologically
active
compounds,
especially
enterolignans
(i.e.,
enterolactone
enterodiol),
which
play
anti-inflammatory
anti-oxidant
roles,
act
estrogen
receptor
activators
modulate
gene
expression
and/or
enzyme
activity.
Interestingly,
recent
evidence
documenting
those
interventions
involving
enriched
have
shown
beneficial
protective
effects
on
various
pathologies,
including
colorectal
breast
cancer
cardiovascular
diseases.
However,
considering
that
more
factors
(e.g.,
diet,
food
transit
time
intestinal
redox
state)
bioactivation
by
GM,
there
usually
remarkable
inter-individual
differences
urine,
fecal
blood
concentrations
enterolignans;
hence,
precise
validated
analytical
methods,
gas/liquid
chromatography
coupled
to
mass
spectrometry,
needed
for
their
accurate
quantification.
Therefore,
this
review
aims
summarize
roles
enterolignans,
interaction
with
GM
new
methodological
approaches
developed
evaluation
different
biological
samples,
since
they
could
be
considered
future
promising
nutraceuticals
prevention
chronic
disorders.
Abstract
Despite
continued
advances
in
prevention
and
treatment
strategies,
cardiovascular
diseases
(CVDs)
remain
the
leading
cause
of
death
worldwide,
more
effective
therapeutic
methods
are
urgently
needed.
Polygonatum
is
a
traditional
Chinese
herbal
medicine
with
variety
pharmacological
applications
biological
activities,
such
as
antioxidant
activity,
anti-inflammation,
antibacterial
effect,
immune-enhancing
glucose
regulation,
lipid-lowering
anti-atherosclerotic
effects,
diabetes
anticancer
effect.
There
has
also
been
evidence
to
support
cardioprotective
effect
recent
years.
However,
up
now,
there
lack
comprehensive
studies
on
active
ingredients
their
pharmacotoxicological
effects
related
diseases.
Therefore,
main
components
(including
Polysaccharides,
Flavonoids,
Saponins)
activities
were
firstly
reviewed
this
paper.
Furthermore,
we
summarized
’s
preventing
treating
CVDs,
its
relevant
toxicological
investigations.
Finally,
emphasize
potential
CVDs.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Plant
polyphenol-based
hydrogels,
known
for
their
biocompatibility
and
adhesive
properties,
have
emerged
as
promising
materials
in
biomedical
applications.
These
hydrogels
leverage
the
catechol
group's
ability
to
form
stable
bonds
moist
environments,
similar
mussel
proteins.
This
review
provides
a
comprehensive
overview
of
synthesis,
adhesion
mechanisms,
applications,
particularly
wound
healing,
tissue
regeneration,
drug
delivery.
However,
challenges
related
vivo
stability
long-term
remain
critical
barriers
clinical
translation.
Future
research
should
focus
on
enhancing
bioactivity,
biocompatibility,
scalability
these
while
addressing
concerns
toxicity,
immune
responses,
large-scale
manufacturing.
Advances
artificial
intelligence-assisted
screening
3D/4D
bioprinting
are
expected
accelerate
development
Furthermore,
integration
biomimetic
designs
responsive
functionalities,
such
pH
or
temperature
sensitivity,
holds
promise
further
improving
therapeutic
efficacy.
In
conclusion,
multifunctional
plant
represents
frontier
advancing
personalized
medicine
minimally
invasive
treatments.
Antioxidants,
Год журнала:
2022,
Номер
11(12), С. 2338 - 2338
Опубликована: Ноя. 25, 2022
A
knotwood
of
coniferous
trees
containing
large
amounts
polyphenolic
extractives
is
considered
a
promising
industrial-scale
source
lignans
possessing
antioxidant
properties
and
other
bioactivities.
The
present
study
aimed
at
detailed
characterization
the
chemical
composition
activity
lignan-rich
obtained
from
Norway
spruce,
Scotch
pine,
Siberian
fir,
larch
growing
in
European
North
Russia
as
region
with
highly
developed
forest
industry.
To
achieve
this,
comprehensive
approach
based
on
combination
two-dimensional
NMR
spectroscopy
high-performance
liquid
chromatography-high-resolution
Orbitrap
mass
spectrometry,
determination
by
three
complementary
methods
were
proposed.
studied
samples
contained
3.9
to
17%
extractive
substances
comparable
Trolox's
single-electron
transfer
processes
superoxide
radical
scavenging,
which
associated
predominance
compounds.
latter
was
represented
12
tentatively
identified
monolignans
27
oligolignans
3-5
phenylpropane
units
their
structure.
extracts
characterized
an
identical
set
differed
only
ratios
individual
Other
components
flavonoids
taxifolin,
quercetin
(Siberian
larch),
stilbenes
(pinosylvin,
its
methyl
ester,
pterostilbene),
pine
extractives.
Sesquiterpene
juvabione
derivatives
found
knotwood.
