Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Май 17, 2024
Язык: Английский
Trends in Food Science & Technology, Год журнала: 2024, Номер 148, С. 104410 - 104410
Опубликована: Апрель 7, 2024
Язык: Английский
Процитировано
19
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9463 - 9463
Опубликована: Авг. 30, 2024
Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential
Язык: Английский
Процитировано
10
Drug Discovery Today, Год журнала: 2024, Номер 29(4), С. 103921 - 103921
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
9
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1174 - 1174
Опубликована: Янв. 29, 2025
Exploring how early-life nutritional interventions may impact future generations, this study examines the inter- and transgenerational effects of in ovo injection bioactive compounds on gene expression cecal tonsils mucosa using a chicken model. Synbiotic PoultryStar® (Biomin) choline were injected 12th day egg incubation. Three experimental groups established generation F1: (1) control group (C) receiving 0.9% physiological saline (NaCl), (2) synbiotic (SYN) 2 mg/embryo, (3) combined (SYNCH) mg 0.25 per embryo. For generations F2 F3, SYN SYNCH each divided into two subgroups: (A) those solely F1 (SYNs SYNCHs) (B) (SYNr SYNCHr). At 21 weeks posthatching, tonsil samples collected from F1, F2, F3 birds for transcriptomic analysis. Gene profiling revealed distinct intergenerational patterns both tissues. In tonsils, significant was noted following drop F2. contrast, showed more changes indicating effects. While some carried they less pronounced, except SYNs group, which experienced an increase compared to The highlights that epigenetic modifications are dynamic unpredictable, with potentially re-emerging later under certain conditions or fading intensifying over time. This provides valuable insights stimulation during embryonic development regulate processes across multiple generations. Our findings provide evidence supporting phenomenon dynamics
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2023, Номер 11(8), С. 2313 - 2313
Опубликована: Авг. 21, 2023
Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney death. The gut microbiota its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in literature on role specific development, this review highlights summarizes current evidence underlying mechanisms associated with We found that microbiota-derived short chain fatty acids, bile branched-chain amino tryptophan indole derivatives well trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles promoting through various mechanisms. Mainly, they modulate complex signaling pathways nuclear kappa-light-chain-enhancer activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, Protein kinase RNA-like endoplasmic reticulum kinase. also highlighted beneficial other cardiovascular metabolic diseases.
Язык: Английский
Процитировано
14
Microorganisms, Год журнала: 2024, Номер 12(8), С. 1570 - 1570
Опубликована: Июль 31, 2024
Inflammatory bowel disease (IBD), which includes Crohn's and ulcerative colitis, involves chronic inflammatory disorders of the digestive tract. Oxidative stress, associated with increased reactive oxygen species generation, is a major risk factor for IBD pathogenesis. Industrialized lifestyles expose us to variety factors that contribute deteriorating gut health, especially patients. Many alternative therapeutic strategies have been developed against oxidative stress along conventional therapy alleviate Polyphenol-rich foods attracted growing interest from scientists due their antioxidant properties. Polyphenols are natural compounds found in plants, fruits, vegetables, nuts exhibit properties protect body damage. This review presents an overview polyphenol benefits describes different types polyphenols. It also discusses polyphenols' role inhibiting fungal growth prevention. Overall, this highlights how healthy balanced diet avoiding industrialized our modern society can minimize damage pathogen infections. polyphenol-rich play important protecting growth.
Язык: Английский
Процитировано
6
BioChem, Год журнала: 2024, Номер 4(3), С. 189 - 216
Опубликована: Июль 29, 2024
Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies emphasized critical role oxidative stress in pathogenesis most common gastrointestinal diseases. To provide comprehensive overview caused by stress, their biological aspects, molecular mechanisms specific pathways, results recent published articles from online databases were studied considering both upper lower parts digestive tract. The revealed that although each part system manifests itself way, all these arise imbalance between generation reactive intermediates (especially oxygen species) antioxidant defense system. Annual incidence mortality statistics worldwide emphasize urgent need to find an effective non-invasive treatment method overcome life-threatening problems. Therefore, next step, variety nanomedicurfines developed treat effect investigated precisely. Furthermore, important nanomedicines responsive endogenous exogenous stimuli evaluated detail. This review could pave way open new horizon effectively treating
Язык: Английский
Процитировано
6
Metabolites, Год журнала: 2024, Номер 14(4), С. 194 - 194
Опубликована: Март 29, 2024
Inflammatory bowel disease (IBD) is multifactorial chronic inflammatory in the gastrointestinal tract, affecting patients' quality of life profoundly. The incidence IBD has been on rise globally for last two decades. Because molecular mechanisms underlying remain not well understood, therapeutic development significantly impeded. Metabolism a crucial cellular process to generate energy needed an response and tissue repair. Comprehensive understanding metabolic pathways would help unravel pathogenesis/progression facilitate discoveries. Here, we investigated four altered experimental colitis. C57BL/6J mice were treated with dextran sulfate sodium (DSS) drinking water 7 days induce ulcerative colitis (UC). We conducted proteomics analysis colon samples using LC/MS, profile key intermediates. Our findings revealed significant alterations major pathways: antioxidative defense, β-oxidation, glycolysis, TCA cycle pathways. metabolism by downregulated under UC, together reduced defense These results reveal re-programming intestinal cells showing dysregulation all study underscores importance drivers pathogenesis suggests that modification may serve as novel diagnostic/therapeutic approach IBD.
Язык: Английский
Процитировано
5