Improvement effects of green tea and pumpkin oils on myelin oligodendrocyte glycoprotein-induced Multiple sclerosis in rats DOI Creative Commons
Nahed S. Lamloum,

Hanan A. Soliman,

Rasha R. Ahmed

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 111, С. 105876 - 105876

Опубликована: Ноя. 10, 2023

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) associated with significant progressive neurodegeneration. There lot interest in use plant-based essential oils traditional medicine to treat and prevent human illnesses, including MS. This research aimed assess neuroprotective effects green tea oil (GTO) pumpkin (PO) against myelin oligodendrocyte glycoprotein (MOG)-induced MS Wistar rats as well investigate underlying molecular mechanisms. The were divided into four groups: group 1, normal control; 2, MOG-injected; groups 3 4, MOG-injected treated 5 ml/kg body weight each GTO PO, respectively. chemical profiles components within PO identified using gas chromatography-mass spectrometry (GC–MS). Treatment substantially improved decreased dopamine, serotonin, norepinephrine, acetylcholine levels brain rats. It also suppressed elevated epinephrine levels. histological injuries cortical tissue notably after supplementing PO. Furthermore, lipid peroxidation serum INF-β concentration significantly lower GSH, SOD, GPx, coenzyme Q10, α-tocopherol enhanced by supplementaion. Additionally, administration upregulated Nrf2, Bcl-2, PCNA while downregulated TNF-α, NF-κB, iNOS, p53, Bax expression Taken together, these findings suggest that efficiently ameliorate MOG-induced via enhancing antioxidant, anti-inflammatory, anti-apoptotic effects.

Язык: Английский

Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signalling? DOI
Daniel Khananshvili

Cell Calcium, Год журнала: 2023, Номер 116, С. 102818 - 102818

Опубликована: Окт. 24, 2023

Язык: Английский

Процитировано

4
Immunoglobulin G and Complement as Major Players in the Neurodegeneration of Multiple Sclerosis DOI Creative Commons
Peter G. E. Kennedy,

M J Fultz,

Jeremiah Phares

и другие.

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1210 - 1210

Опубликована: Сен. 26, 2024

Multiple Sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) termed as one most common causes neurological disability in young adults. Axonal loss neuronal cell damage are primary progression disability. Yet, little known about mechanism neurodegeneration disease, a limitation that impairs development more effective treatments for progressive MS. MS characterized by presence oligoclonal bands raised levels immunoglobulins CNS. The role complement demyelinating process has been detected both experimental animal models within CNS affected patients. Furthermore, IgG antibodies activation can be plaques cortical gray matter lesions. We propose here play active hypothesize increased form aggregates bind C1q with high affinity, activating classical pathway. This results damage, which leads to demyelination

Язык: Английский

Процитировано

1
From Organotypic Mouse Brain Slices to Human Alzheimer’s Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth DOI Creative Commons
Necat Yılmaz, Katharina Steiner,

Josef Marksteiner

и другие.

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1326 - 1326

Опубликована: Окт. 18, 2024

Alzheimer's disease (AD) is a neurodegenerative characterized by memory loss and progressive deterioration of cognitive functions. Being able to identify reliable biomarkers in easily available body fluids such as blood plasma vital for the disease. To achieve this, we used technique that applied human organotypic brain slice culture via microcontact printing. After 2-week period, performed immunolabeling neurofilament myelin oligodendrocyte glycoprotein (MOG) visualize newly formed nerve fibers oligodendrocytes. There was no significant change number new AD group compared healthy control group, while length produced significantly decreased. A increase MOG+ dots around these detected patient group. According our hypothesis, there are factors patients affect growth fibers, which also Based on findings, selected most promising samples conducted mass spectrometry using differential approach identified three putative biomarkers: aldehyde-dehydrogenase 1A1, alpha-synuclein protein S100-A4. Our method represents novel innovative translating research findings from mouse models applications.

Язык: Английский

Процитировано

1
Adiponectin Alleviates Cell Injury due to Cerebrospinal Fluid from Multiple Sclerosis Patients by Inhibiting Oxidative Stress and Proinflammatory Response DOI Creative Commons
Marta Mallardo, Elisabetta Signoriello, Giacomo Lus

и другие.

Biomedicines, Год журнала: 2023, Номер 11(6), С. 1692 - 1692

Опубликована: Июнь 12, 2023

Multiple sclerosis (MS) is the most common disabling neurological disease characterized by chronic inflammation and neuronal cell viability impairment. Based on previous studies reporting that adiponectin exhibits neuroprotective effects in some models of neurodegenerative diseases, we analyzed AdipoRon treatment, alone or combination with cerebrospinal fluid patients MS (MS-CSF), to verify whether this adipokine acts basal cellular processes. To aim, SH-SY5Y U-87 cells (models glial cells, respectively) were exposed MS-CSF co-treatment AdipoRon. The was determined via MTT assay, possible underlying mechanisms investigated alterations oxidative stress inflammation. assay confirmed did not affect both lines; whereas, when used MS-CSF, it reduces inhibitory lines. In addition, treatment causes an increase pro-inflammatory cytokines, whereas determines reduction anti-inflammatory IL-10. Interestingly, co-administration counteracts MS-CSF-induced production enhancement conclusion, our data suggest cytotoxic induced lines one potential molecular might occur Further vivo vitro are essential confirm could be a neuro-protectant candidate against injury.

Язык: Английский

Процитировано

2
Improvement effects of green tea and pumpkin oils on myelin oligodendrocyte glycoprotein-induced Multiple sclerosis in rats DOI Creative Commons
Nahed S. Lamloum,

Hanan A. Soliman,

Rasha R. Ahmed

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 111, С. 105876 - 105876

Опубликована: Ноя. 10, 2023

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) associated with significant progressive neurodegeneration. There lot interest in use plant-based essential oils traditional medicine to treat and prevent human illnesses, including MS. This research aimed assess neuroprotective effects green tea oil (GTO) pumpkin (PO) against myelin oligodendrocyte glycoprotein (MOG)-induced MS Wistar rats as well investigate underlying molecular mechanisms. The were divided into four groups: group 1, normal control; 2, MOG-injected; groups 3 4, MOG-injected treated 5 ml/kg body weight each GTO PO, respectively. chemical profiles components within PO identified using gas chromatography-mass spectrometry (GC–MS). Treatment substantially improved decreased dopamine, serotonin, norepinephrine, acetylcholine levels brain rats. It also suppressed elevated epinephrine levels. histological injuries cortical tissue notably after supplementing PO. Furthermore, lipid peroxidation serum INF-β concentration significantly lower GSH, SOD, GPx, coenzyme Q10, α-tocopherol enhanced by supplementaion. Additionally, administration upregulated Nrf2, Bcl-2, PCNA while downregulated TNF-α, NF-κB, iNOS, p53, Bax expression Taken together, these findings suggest that efficiently ameliorate MOG-induced via enhancing antioxidant, anti-inflammatory, anti-apoptotic effects.

Язык: Английский

Процитировано

2