Journal of Advance Research in Medical & Health Science (ISSN 2208-2425),
Год журнала:
2023,
Номер
9(3), С. 63 - 67
Опубликована: Март 10, 2023
Background:
As
a
leading
cause
of
visual
impairment
in
elderly,
age-related
macular
degeneration
has
an
increasing
global
incidence
annually.
It’s
association
towards
cataract
surgery
remains
debate.
Aim:
The
objective
this
study
is
to
summarize
and
evaluate
the
between
degeneration.
Methods:
A
systematic
search
strategy
was
conducted
across
several
electronic
reference
databases
(PubMed,
Cochrane
Library,
ProQuest)
included
articles
published
2018–2023.
Duplicate
publications,
review
articles,
incomplete
were
excluded.
Results:
Databases
searching
identified
total
254
articles.
Of
these,
29
passed
screening
process
resulted
12
for
full-text
assessment.
6
did
not
outcome
interest.
Hence,
we
found
six
appropriate
studies
review.
Conclusion:
results
suggest
that
there
may
be
increased
risk
AMD
progression
development.
This
increase
according
time
follow-up
since
surgery.
To
improve
medical
treatment
patients
with
AMD,
additional
research
essential
understanding
disease
state
its
impact
on
mainly
prospective
multicenter
RCT
studies.
Abstract
This
comprehensive
review
delves
into
a
unique
intersection
of
hydrogels
as
smart
molecules
and
their
transformative
applications
in
ophthalmology.
Beginning
with
the
foundational
definition,
properties,
classification
hydrogels,
explores
synthesis
responsive
capabilities.
Specific
examined
encompass
topical
drug
delivery,
contact
lenses,
intravitreal
ocular
adhesives,
vitreous
substitutes,
cell‐based
therapy.
A
methodical
analysis,
including
an
overview
relevant
structures
comparative
evaluation
hydrogel‐based
solutions
against
traditional
treatments,
is
conducted.
Additionally,
potential
constraints,
translation
challenges,
knowledge
gaps,
research
areas
are
identified.
Our
approach,
guided
by
extensive
literature
from
2017
to
2023,
illuminates
unprecedented
opportunities
offered
along
pinpointing
for
further
inquiry
facilitate
transition
clinical
practice.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Март 28, 2023
As
the
only
blood
vessels
that
can
directly
be
seen
in
whole
body,
pathological
changes
retinal
are
related
to
metabolic
state
of
body
and
many
systems,
which
seriously
affect
vision
quality
life
patients.
Timely
diagnosis
treatment
key
improving
prognosis.
In
recent
years,
with
rapid
development
artificial
intelligence,
application
intelligence
ophthalmology
has
become
increasingly
extensive
in-depth,
especially
field
vascular
diseases.
Research
study
results
based
on
fundus
images
remarkable
provides
a
great
possibility
for
early
treatment.
This
paper
reviews
research
progress
diseases
(including
diabetic
retinopathy,
hypertensive
vein
occlusion,
retinopathy
prematurity,
age-related
macular
degeneration).
The
limitations
challenges
process
also
discussed.
Bioactive Materials,
Год журнала:
2023,
Номер
30, С. 142 - 153
Опубликована: Июль 31, 2023
Age-related
macular
degeneration
(AMD)
causes
blindness
due
to
loss
of
retinal
pigment
epithelium
(RPE)
and
photoreceptors
(PRs),
which
comprise
the
two
outermost
layers
retina.
Given
small
size
macula
importance
direct
contact
between
RPE
PRs,
use
scaffolds
for
targeted
reconstruction
outer
retina
in
later
stage
AMD
other
dystrophies
is
particularly
attractive.
We
developed
microfabricated,
honeycomb-patterned,
biodegradable
poly(glycerol
sebacate)
(PGS)
deliver
organized,
adjacent
PRs
subretinal
space.
Furthermore,
an
optimized
process
was
photocure
PGS,
shortening
scaffold
production
time
from
days
minutes.
The
resulting
robustly
supported
seeding
human
pluripotent
stem
cell-derived
either
separately
or
as
a
dual
cell-layered
construct.
These
advanced,
economical,
versatile
can
accelerate
cell
transplantation
efforts
benefit
patients
with
degenerative
diseases.
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1647 - 1647
Опубликована: Окт. 8, 2024
The
most
prevalent
reason
for
vision
impairment
in
aging
inhabitants
is
age-related
macular
degeneration
(AMD),
a
posterior
ocular
disease
with
poor
understanding
of
the
anatomic,
genetic,
and
pathophysiological
progression
disease.
Recently,
new
insights
exploring
role
atrophic
changes
retinal
pigment
epithelium,
extracellular
drusen
deposits,
lysosomal
lipofuscin,
various
genes
have
been
investigated
AMD.
Hence,
this
review
explores
incidence
risk
factors
AMD,
such
as
oxidative
stress,
inflammation,
complement
system,
involvement
bioactive
lipids
their
angiogenesis.
In
addition
to
intravitreal
anti-vascular
endothelial
growth
factor
(VEGF)
therapy
other
therapeutic
interventions
oral
kinase
inhibitors,
photodynamic,
gene,
antioxidant
therapy,
well
benefits
drawbacks
AMD
treatment
options,
strategic
drug
delivery
methods,
including
routes
focus
on
pharmacokinetics,
are
investigated.
Further,
recent
advancements
nanoformulations
polymeric
lipid
nanocarriers,
liposomes,
etc.,
intended
pros
cons
too
summarized.
Therefore,
purpose
give
researchers
an
pathophysiology,
emphasis
angiogenesis,
function
lipids,
options.
Additionally,
options
that
development
system(s)
via
several
can
aid
advancement
choices.
Journal of Personalized Medicine,
Год журнала:
2023,
Номер
13(4), С. 635 - 635
Опубликована: Апрель 5, 2023
Oxidation
of
lipids
and
lipoproteins
contributes
to
inflammation
processes
that
promote
the
development
eye
diseases.
This
is
a
consequence
metabolism
dysregulation;
for
instance,
dysfunctional
peroxisomal
lipid
metabolism.
Dysfunction
peroxidation
critical
factor
in
oxidative
stress
causes
ROS-induced
cell
damage.
Targeting
treat
ocular
diseases
an
interesting
effective
approach
now
being
considered.
Indeed,
among
structures,
retina
fundamental
tissue
shows
high
Lipids
glucose
are
fuel
substrates
photoreceptor
mitochondria;
therefore,
rich
lipids,
especially
phospholipids
cholesterol.
The
imbalance
cholesterol
homeostasis
accumulation
human
Bruch's
membrane
related
diseases,
such
as
AMD.
In
fact,
preclinical
tests
performed
mice
models
with
AMD,
making
this
area
promising
field.
Nanotechnology,
on
other
hand,
offers
opportunity
develop
site-specific
drug
delivery
systems
tissues
treatment
Specially,
biodegradable
nanoparticles
constitute
treating
metabolic
eye-related
pathologies.
Among
several
systems,
show
attractive
properties,
e.g.,
no
toxicological
risk,
easy
scale-up
increased
bioavailability
loaded
active
compounds.
review
analyses
mechanisms
involved
dyslipidemia,
well
their
manifestations.
Moreover,
compounds
which
aim
target
retinal
metabolism-related
thoroughly
discussed.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(7)
Опубликована: Апрель 5, 2024
Biomaterials
denoting
self-healing
and
versatile
structural
integrity
are
highly
curious
in
the
biomedicine
segment.
The
injectable
and/or
printable
3D
printing
technology
is
explored
a
few
decades
back,
which
can
alter
their
dimensions
temporarily
under
shear
stress,
showing
potential
healing/recovery
tendency
with
patient-specific
intervention
toward
development
of
personalized
medicine.
Thus,
hydrogels
(IHs)
stunning
developing
paradigm
for
tissue
regeneration.
This
review
comprises
designing
IHs,
rheological
characterization
stability,
several
benchmark
consequences
translation
into
regeneration
specific
types,
applications
IHs
biomedical
such
as
anticancer
immunomodulation,
wound
healing
tissue/bone
regeneration,
antimicrobial
potentials,
drugs,
gene
vaccine
delivery,
ocular
printing,
cosmeceuticals,
photothermal
therapy
well
other
allied
avenues
like
agriculture,
aerospace,
electronic/electrical
industries,
coating
approaches,
patents
associated
therapeutic/nontherapeutic
avenues,
numerous
futuristic
challenges
solutions.
Age-related
macular
degeneration
is
a
degenerative
eye
condition
that
affects
the
macula
and
results
in
central
vision
loss.
Phytoconstituents
show
great
promise
treatment
of
AMD.
AMD
therapy
can
benefit
from
advantages
phytoconstituents
loaded
nanofibers.
There
are
opportunities
to
improve
effectiveness
age-related
(AMD)
through
use
nanofiber-based
delivery
methods.
These
novel
platforms
encapsulate
distribute
plant-derived
bioactives
by
making
special
qualities
include
their
high
surface
area-to-volume
ratio,
variable
porosity,
biocompatibility.
Exploring
methods
provide
choice
for
enhancing
patient
adherence,
safety,
efficacy
managing
this
condition.
This
article
explores
potential
revolutionize
treatment,
providing
an
innovative
effective
approach
treat
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 25, 2024
Abstract
Three-dimensional
(3D)
bioprinting
is
considered
one
of
the
most
advanced
tools
to
build
up
materials
for
tissue
engineering.
The
aim
this
work
was
design,
development
and
characterization
a
bioink
composed
human
mesenchymal
stromal
cells
(hMSC)
extrusion
through
nozzles
create
these
3D
structures
that
might
potentially
be
apply
replace
function
damaged
natural
tissue.
In
study,
we
focused
on
advantages
wide
potential
biocompatible
biomaterials,
such
as
hyaluronic
acid
alginate
inclusion
hMSC.
characterized
its
physical
(pH,
osmolality,
degradation,
swelling,
porosity,
surface
electrical
properties,
conductivity,
structure),
mechanical
(rheology
printability)
biological
(viability
proliferation)
properties.
developed
showed
high
porosity
swelling
capacity,
while
degradation
rate
dependent
temperature.
also
negative
appropriate
rheological
properties
required
bioprinting.
Moreover,
stress-stability
studies
did
not
show
any
sign
instability.
provided
an
excellent
environment
promotion
viability
growth
hMSC
cells.
Our
reports
first-time
study
effect
storage
temperature
cell
bioinks,
besides
showing
our
promoted
after
being
extruded
by
bioprinter.
These
results
support
suggestion
hMSC-composed
fulfills
all
requirements
engineering
can
proposed
tool
with
applications
in
regenerative
medicine
Graphical
abstract
