Molecules,
Год журнала:
2023,
Номер
28(16), С. 6071 - 6071
Опубликована: Авг. 15, 2023
Yellow
Himalayan
raspberry
(Rubus
ellipticus
Sm.,
Rosaceae)
is
a
native
species
of
the
Indian
subcontinent,
Southern
China,
and
Philippines,
which
has
been
historically
used
as
traditional
medicine
food.
All
parts
this
plant
have
in
to
treat
respiratory
ailments,
diabetes,
gastrointestinal
disorder,
an
anti-infective
agent.
The
scientific
evaluation
revealed
richness
macronutrients,
micronutrients,
minerals
fruits,
indicating
its
potential
use
nutraceutical.
Furthermore,
found
be
rich
various
secondary
metabolites,
including
polyphenols,
flavonoids,
anthocyanins,
tannins,
terpenoids.
Ascorbic
acid,
kaempferol,
gallic
catechin
are
some
compounds
plant,
widely
discussed
for
their
health
benefits.
extracts
obtained
from
R.
shown
antioxidant,
antidiabetic,
anticancer,
anti-inflammatory,
nephroprotective,
antipyretic,
anticonvulsant,
activities
investigated
through
different
study
models.
These
findings
literature
validated
widespread
uses
fruits
folk
medicinal
systems
consumption
nutritious
wild
fruit
by
local
communities.
In
conclusion,
holds
strong
development
It
can
also
improve
nutritional
status
villagers
uplift
economy
if
properly
utilized
marketed.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 251 - 251
Опубликована: Дек. 23, 2023
Apigenin
is
one
of
the
most
widespread
flavonoids
in
plant
kingdom.
For
centuries,
apigenin-containing
preparations
have
been
used
traditional
medicines
to
treat
diseases
that
an
inflammatory
and/or
degenerative
component.
In
1980s,
apigenin
was
proposed
interfere
with
process
carcinogenesis.
Since
then,
more
and
evidence
has
demonstrated
its
anticancer
efficacy,
both
vitro
vivo.
shown
target
signaling
pathways
involved
development
progression
cancer,
such
as
PI3K/Akt/mTOR,
MAPK/ERK,
JAK/STAT,
NF-κB,
Wnt/β-catenin
pathways,
modulate
different
hallmarks
cell
proliferation,
metastasis,
apoptosis,
invasion,
migration.
Furthermore,
modulates
PD1/PD-L1
expression
cancer/T
killer
cells
regulates
percentage
T
regulatory
cells.
Recently,
studied
for
synergic
additive
effects
when
combined
chemotherapy,
minimizing
side
effects.
Unfortunately,
low
bioavailability
high
permeability
limit
therapeutic
applications.
Based
on
micro-
nanoformulations
enhance
physical
stability
drug-loading
capacity
increase
apigenin,
novel
drug-delivery
systems
investigated
improve
solubility.
Bulletin of the National Research Centre/Bulletin of the National Research Center,
Год журнала:
2024,
Номер
48(1)
Опубликована: Апрель 19, 2024
Abstract
Background
Type
1
diabetes
(T1D)
is
an
autoimmune
disease
leading
to
destruction
of
insulin-producing
pancreatic
beta
cells.
Both
genetic
and
environmental
factors
contribute
pathogenesis.
The
incidence
T1D
increasing
worldwide,
with
significant
geographic
ethnic
variations.
Patients
present
symptoms
hyperglycemia
complications.
Main
body
In
T1D,
autoreactive
T
cells
autoantibodies
destroy
cells,
causing
insulin
deficiency.
Exogenous
therapy
essential
but
cannot
replicate
normal
physiology.
Management
requires
intensive
lifestyle
education
on
diet,
exercise,
glucose
monitoring
avoiding
complications,
in
addition
insulin.
Novel
therapies
like
immunotherapy,
cell
transplantation,
artificial
pancreas
devices
AI
algorithms
aim
improve
care.
Strategies
for
reversing
involve
combination
immunotherapies
block
autoimmunity
regenerate
via
stem
or
xenotransplantation.
Conclusion
While
type
remains
challenging,
ongoing
research
provides
hope.
Elucidating
individualized
mechanisms
translating
findings
into
precision
prevention
treatment
approaches
are
critical
improving
long-term
outcomes.
Innovative
multi-targeted
may
fundamentally
change
the
trajectory
T1D.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 4202 - 4229
Опубликована: Июнь 26, 2024
Abstract
Glucolipid
metabolism
disorder
(GLMD)
is
a
complex
chronic
disease
characterized
by
glucose
and
lipid
disorders
with
diverse
etiology
rapidly
increasing
incidence.
Many
studies
have
identified
the
role
of
flavonoids
in
ameliorating
GLMD,
mechanisms
related
to
peroxisome
proliferator‐activated
receptors,
nuclear
factor
kappa‐B,
AMP‐activated
protein
kinase,
(erythroid‐derived
2)‐like
2,
transporter
type
4,
phosphatidylinositol‐3‐kinase/protein
kinase
B
pathway.
However,
comprehensive
summary
flavonoid
effects
on
GLMD
lacking.
This
study
reviewed
roles
natural
different
structures
treatment
reported
globally
past
5
years
provides
reference
for
developing
as
drugs
treating
GLMD.
Molecules,
Год журнала:
2022,
Номер
28(1), С. 126 - 126
Опубликована: Дек. 23, 2022
Diabetes
mellitus
is
a
metabolic
disorder
which
one
of
the
leading
causes
mortality
and
morbidities
in
elderly
humans.
Chronic
diabetes
can
lead
to
kidney
failure,
blindness,
limb
amputation,
heart
attack
stroke.
Physical
activity,
healthy
diets
medications
reduce
incidence
diabetes,
so
search
for
more
efficient
antidiabetic
therapies,
most
especially
from
natural
products,
necessity.
Herein,
extract
roots
medicinal
plant
Pterocarpus
erinaceus
was
purified
by
column
chromatography
afforded
ten
compounds
were
characterized
EIMS,
HR-FAB-MS,
1D
2D
NMR
techniques.
Amongst
them
were,
new
trimeric
derivative
epicatechin,
named
2,3-Epoxyprocyanidin
C1
(1);
two
pentacyclic
triterpenoids,
friedelin
(2)
betulin
(3);
angolensin
(4);
flavonoids
such
as
7-methoxygenistein
(5),
7-methoxydaidzein
(6),
apigenin
7-O-glucoronide
(8)
naringenin
7-O-β-D-glucopyranoside
(9);
an
ellagic
acid
(10).
The
evaluated
their
potential
α-amylase
α-glucosidase
inhibitory
assays.
IC50
values
compound
7
(48.1
±
0.9
µg/mL),
8
(48.6
0.1
9
(50.2
0.5
µg/mL)
(40.5
0.8
when
compared
that
acarbose
(26.4
0.3
indicated
good
inhibition.
In
assay,
(IC50
=
31.2
39.5
1.2
40.9
1.3
1
41.6
1.0
Compound
4
43.4
5
47.6
6
46.3
0.2
45.0
44.8
0.6
11
47.5
0.4
all
had
moderate-to-good
inhibitions,
22.0
µg/mL).
ability
inhibit
indicates
P.
its
lower
blood
glucose
levels
delaying
hydrolysis
carbohydrates
into
sugars,
thereby
providing
source
remedy.
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6071 - 6071
Опубликована: Авг. 15, 2023
Yellow
Himalayan
raspberry
(Rubus
ellipticus
Sm.,
Rosaceae)
is
a
native
species
of
the
Indian
subcontinent,
Southern
China,
and
Philippines,
which
has
been
historically
used
as
traditional
medicine
food.
All
parts
this
plant
have
in
to
treat
respiratory
ailments,
diabetes,
gastrointestinal
disorder,
an
anti-infective
agent.
The
scientific
evaluation
revealed
richness
macronutrients,
micronutrients,
minerals
fruits,
indicating
its
potential
use
nutraceutical.
Furthermore,
found
be
rich
various
secondary
metabolites,
including
polyphenols,
flavonoids,
anthocyanins,
tannins,
terpenoids.
Ascorbic
acid,
kaempferol,
gallic
catechin
are
some
compounds
plant,
widely
discussed
for
their
health
benefits.
extracts
obtained
from
R.
shown
antioxidant,
antidiabetic,
anticancer,
anti-inflammatory,
nephroprotective,
antipyretic,
anticonvulsant,
activities
investigated
through
different
study
models.
These
findings
literature
validated
widespread
uses
fruits
folk
medicinal
systems
consumption
nutritious
wild
fruit
by
local
communities.
In
conclusion,
holds
strong
development
It
can
also
improve
nutritional
status
villagers
uplift
economy
if
properly
utilized
marketed.
