Diet for the prevention and management of sarcopenia

Metabolism, Год журнала: 2023, Номер 146, С. 155637 - 155637

Опубликована: Июнь 21, 2023

Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.

Язык: Английский

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Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Nutrients, Год журнала: 2023, Номер 16(1), С. 63 - 63

Опубликована: Дек. 25, 2023

Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) associated with faster more relevant impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk falls, frailty, overall quality life, mortality. PubMed/Medline, Scopus, Web Science, Google Scholar were searched for research articles, scientific reports, observational studies, trials, narrative systematic reviews, meta-analyses review evidence pathophysiology di-abetes-induced sarcopenia, its relevance in terms glucose control diabetes-related outcomes, diagnostic therapeutic challenges. The comprehensively addresses key elements definition criteria pathophysiological correlation be-tween T2D, related a critical role antihyperglycemic treatment health, perspectives specific targeting myokine signaling pathways involved regulation metabolism trophism. Prompt diagnosis adequate management, including lifestyle inter-vention, diet programs, micronutrient supplementation, physical exercise, pharmaco-logical treatment, are needed prevent or delay T2D.

Язык: Английский

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Exerkines and cardiometabolic benefits of exercise: from bench to clinic

EMBO Molecular Medicine, Год журнала: 2024, Номер 16(3), С. 432 - 444

Опубликована: Фев. 6, 2024

Abstract Regular exercise has both immediate and long-lasting benefits on cardiometabolic health, been recommended as a cornerstone of treatment in the management diabetes cardiovascular conditions. Exerkines, which are defined humoral factors responsive to acute or chronic exercise, have emerged important players conferring some multiple exercise. Over past decades, hundreds exerkines released from skeletal muscle, heart, liver, adipose tissue, brain, gut identified, several (such FGF21, IL-6, adiponectin) exploited therapeutically mimetics for various metabolic diseases. Recent advances metagenomics led identification microbiota, so-called “hidden” organ, an additional class determining efficacy prevention, cardiac protection, performance. Furthermore, multiomics-based studies shown feasibility using baseline exerkine signatures predict individual responses with respect cardiorespiratory health. This review aims explore molecular pathways whereby networks mediate adaptations by fine-tuning inter-organ crosstalk, discuss roadmaps translating exerkine-based discovery into therapeutic application personalized medicine disease.

Язык: Английский

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Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694

Опубликована: Март 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Язык: Английский

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Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 2, 2024

Abstract The association between sarcopenia and OA still presents many uncertainties. We aimed to assess whether is associated with occurrence of in US adults. conducted a cross-sectional study consisting 11,456 participants from National Health Nutrition Examination Survey 1999–2006. Sarcopenia was defined by low muscle mass. skeletal index (SMI) calculated as the appendicular mass divided body indexes (BMI) or weight. status assessed using self-reported questionnaire. evaluated multivariate regression models. In addition, subgroup interaction analysis were performed. when it BMI-adjusted SMI (OR = 1.23 [95% CI, 1.01, 1.51]; P 0.038) weight-adjusted 1.30 1.10, 1.55]; 0.003). Subgroup found that strongest positive mainly exists smoker 1.54 1.21, 1.95], Pint 0.006), this not significant other groups. conclusion, we OA. revealed more pronounced smoker. Further well-designed prospective cohort studies are needed our results.

Язык: Английский

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721

Опубликована: Авг. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

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AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 484 - 484

Опубликована: Янв. 8, 2025

Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.

Язык: Английский

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Association between daily sitting time and sarcopenia in the US population: a cross-sectional study

Archives of Public Health, Год журнала: 2025, Номер 83(1)

Опубликована: Янв. 10, 2025

Sarcopenia is an age-related syndrome marked by a gradual decline in skeletal muscle mass and function. While various factors influencing sarcopenia have been studied, the link between daily sedentary time remains underexplored. This study analyzed association sitting using data from National Health Nutrition Examination Survey (NHANES 2011–2018). Daily was assessed through questionnaires, while measured body index (BMI) adjusted appendicular (ASM). The relationship weighted logistic regression models smoothing curves. Stratified analyses interaction testing were employed to investigate population-specific characteristics of this association. Furthermore, chi-square test grouped used further analyze impact vigorous activity on two variables. included 9998 participants with complete information. fully model showed significant positive correlation prevalence (OR = 1.07, 95% CI: 1.03–1.10, P 0.0026). group ≥ 9 h had 90% higher risk compared < 4 1.90, 1.22–2.84, 0.0040). Smooth curve fitting analysis linear relationship. shows that non-Hispanic white men lower BMI (BMI 25) sarcopenia. Compared those who actively participate activities, individuals lack recreational activities Our research has found increased significantly increases sarcopenia, especially among BMI. Additionally, physical also Therefore, reducing behavior increasing moderate exercise may be effective prevention strategies.

Язык: Английский

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Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Clinical Interventions in Aging, Год журнала: 2024, Номер Volume 19, С. 827 - 841

Опубликована: Май 1, 2024

Abstract: This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese intestinal microecology, and rehabilitation therapies individuals with limited limb movement. By analyzing multiple studies, the aims to summarize available evidence manage diseases. The results strongly emphasize role resistance training addressing diseases secondary sarcopenia. Maintaining appropriate frequency intensity can help prevent muscle atrophy effectively reduce inflammation. Although aerobic exercise has ability improve skeletal mass, it does have some positive effects physical function. Building upon this, explores potential benefits combined approaches, highlighting their helpfulness overall quality life. Additionally, also highlights importance supplements combating It protein intake, rich essential amino acids omega-3, as well sufficient vitamin D atrophy. Combining appears be an effective strategy preventing sarcopenia, although optimal dosage type supplement remain unclear. Furthermore, microecology Probiotics, prebiotics, bacterial products are suggested new treatment options emerging such whole body vibration training, blood flow restriction, electrical stimulation show promise treating Overall, this provides valuable insights into emphasizes holistic integrated approach that incorporates nutrition, multidisciplinary interventions, which promote health elderly population. Future research should prioritize high-quality randomized controlled trials utilize wearable devices, smartphone applications, other advanced surveillance methods investigate most intervention associated different Keywords: disease, inflammation

Язык: Английский

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Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies

Phytomedicine, Год журнала: 2023, Номер 123, С. 155170 - 155170

Опубликована: Ноя. 3, 2023

Язык: Английский

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