Multifunctional Inhibitors of Cholinesterases for the Therapy of Alzheimer’s Disease (A Review)

Russian Journal of General Chemistry, Год журнала: 2023, Номер 93(S2), С. S528 - S549

Опубликована: Дек. 1, 2023

Язык: Английский

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Changes in cognitive ability and serum microRNA levels during aging in mice

Experimental and Therapeutic Medicine, Год журнала: 2024, Номер 27(3)

Опубликована: Янв. 29, 2024

Mild cognitive impairment (MCI) is an early stage that can result in dementia. MCI be reversed, and diagnosis at crucial to control the progression Dementia currently diagnosed based on interviews screening tests; however, novel biomarkers must identified allow detection. Therefore, present study aimed identify form of blood microRNAs (miRNAs/miRs) for or Blood samples were collected from C57BL/6NJcl male mice four time points, including 4‑week‑old (4W), 8‑week‑old (8W), 36‑week‑old (36W) 58‑week‑old (58W), serum was isolated. Body weight total cholesterol levels increased, alkaline phosphatase decreased with aging. The 8W exhibited highest ability Morris water maze test, whereas 58W demonstrated ability. RNA concentrations 4W, 8W, 36W no significant differences. Furthermore, small detected all mice. miRNA microarray analysis revealed a >1.5‑fold increase expression two miRNAs (miR‑21a‑5p miR‑92a‑3p) decrease other (miR‑6769b‑5p miR‑709) compared those In future, we aim further analyze aged discover biomarkers.

Язык: Английский

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Pathogenesis of Dementia

Опубликована: Янв. 1, 2024

Язык: Английский

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Analyzing public discourse of dementia from Spanish and English tweets: a comparative analysis with other neurological disorders

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Окт. 24, 2024

Dementia comprise a broad spectrum of cognitive declines affecting 47 million people worldwide, with numbers projected to reach 131 by 2050. Predominantly associated older adults, dementia can also impact younger individuals, having significant on daily functioning the affected patients, relatives, caregivers and socioeconomic system. Recent research underscores utility social media, particularly X (previously designed as Twitter), in understanding public perceptions sentiments related neurological disorders. Despite some initial studies have explored X, broader deeper analysis this condition is still warranted.

Язык: Английский

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Innovative strategies for overcoming blood-brain barrier challenges in Alzheimer’s disease: A focus on green-synthesized metallic nanoparticles

Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113604 - 113604

Опубликована: Ноя. 1, 2024

Язык: Английский

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