Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115805 - 115805

Опубликована: Окт. 31, 2023

Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, most importantly, association between potential CBD nuclear factor erythroid 2-related 2 (Nrf2) signaling pathway. The relationship Nrf2 is closely linked to certain proteins are associated with cardiovascular dysfunctions, cancers, neurodegenerative conditions. Specifically, connected initiation progression diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, obesity, myocardial injury angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's Parkinson's neuroinflammation, Amyotrophic Lateral Sclerosis, Multiple Sclerosis. zone great interest in medical field, it significantly impact treatment prevention wide-ranging Additional investigation necessary entirely apprehend mechanisms underlying this crucial interplay develop effective interventions.

Язык: Английский

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Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation

Brain Research, Год журнала: 2024, Номер 1828, С. 148771 - 148771

Опубликована: Янв. 17, 2024

Язык: Английский

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Co-Dispersion Delivery Systems with Solubilizing Carriers Improving the Solubility and Permeability of Cannabinoids (Cannabidiol, Cannabidiolic Acid, and Cannabichromene) from Cannabis sativa (Henola Variety) Inflorescences

Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2280 - 2280

Опубликована: Сен. 4, 2023

Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges related to their bioavailability therapeutic efficacy upon oral administration. To overcome these limitations, we developed co-dispersion cannabinoid delivery systems the biopolymer polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) magnesium aluminometasilicate (Neusilin US2) improve solubility permeability. Recognizing potential benefits arising from entourage effect, decided work an extract instead of isolated cannabinoids. Cannabis sativa inflorescences (Henola variety) a confirming neuroprotective activity were subjected dynamic supercritical CO2 (scCO2) extraction next they combined carriers (1:1 mass ratio) prepare (HiE). In vitro dissolution studies conducted evaluate CBD, CBDA, CBC various media (pH 1.2, 6.8, fasted, fed state simulated intestinal fluid). The HiE-Soluplus consistently demonstrated highest rate Additionally, exhibited permeability coefficients for cannabinoids gastrointestinal tract conditions than it was during using model PAMPA GIT. All three promising blood-brain barrier (BBB) (Papp higher 4.0 × 10−6 cm/s), suggesting effectively cross into central nervous system. improved system hold promise enhancement bioavailability.

Язык: Английский

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Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential

Molecules, Год журнала: 2024, Номер 29(22), С. 5471 - 5471

Опубликована: Ноя. 20, 2024

Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as promising therapeutic agent with diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option the clinic. Recent research shed light on CBG's intriguing molecular mechanisms, highlighting to modulate multiple physiological processes. This review delves into current understanding interactions and explores power alleviate various conditions, including cancer, metabolic, pain, inflammatory disorders, amongst others. We discuss how interacts endocannabinoid system other key signaling pathways, such CB1, CB2, TPR channels, α2-adrenoceptor, potentially influencing inflammation, neurodegeneration, ailments. Additionally, we highlight ongoing efforts aimed at elucidating full spectrum safety profile clinical settings. Through this comprehensive analysis, aim provide deeper role promoting human health pave way for future endeavors.

Язык: Английский

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Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1284 - 1284

Опубликована: Окт. 24, 2024

The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with genesis/progression of several pathological conditions, including cancer, inflammation, neurodegenerative disorders, that directly indirectly correlated to a wide set events collectively named under term "ER stress". Despite recent increase interest concerning ER activity, further research studies needed highlight all mechanisms responsible for failure. In this field, discoveries paved way comprehension strong interaction between stress development endocannabinoid system. activity system mediated by activation cannabinoid receptors (CB), G protein-coupled induce decrease cAMP levels, downstream anti-inflammatory effects. CB drives, most cases, recovery through regulation hallmarks PERK, ATF6, IRE1. review, we focus on role modulating stress, particular attention processes leading UPR oxidative response extinguishment, underlying natural cannabinoids' modulation complex machine.

Язык: Английский

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Effects of Full-Spectrum Cannabis Oil with a Cannabidiol:Tetrahydrocannabinol 2:1 Ratio on the Mechanisms Involved in Hepatic Steatosis and Oxidative Stress in Rats Fed a Sucrose-Rich Diet

Medical Cannabis and Cannabinoids, Год журнала: 2023, Номер 6(1), С. 170 - 183

Опубликована: Ноя. 15, 2023

Introduction: This study aimed to analyze the effects of cannabis oil (cannabidiol:tetrahydrocannabinol [CBD:THC], 2:1 ratio) on mechanisms involved in hepatic steatosis and oxidative stress an experimental model metabolic syndrome (MS) induced by a sucrose-rich diet (SRD). We hypothesized that noninvasive oral administration improves through lower activity lipogenic enzymes increase carnitine palmitoyltransferase-1 (CPT-1) enzyme mitochondrial oxidation fatty acids. Furthermore, ameliorates liver regulation main regulatory factors involved, nuclear factor erythroid 2 (NrF2) factor-kB (NF-κB) p65. For testing this hypothesize, relevant MS was feeding rats with SRD for 3 weeks. Methods: Male Wistar were fed following diets weeks: reference diet: standard commercial laboratory diet, SRD, + oil: 1 mg/kg body weight daily. The full-spectrum presents total cannabinoid CBD:THC ratio. Serum glucose, triglyceride, cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, alanine aminotransferase, aspartate alkaline phosphatase (AP), N-arachidonoylethanolamine or anandamide 2-arachidonoylglycerol endocannabinoids levels, thiobarbituric acid reactive substance (TBARS) non-enzymatic antioxidant capacity (ferric ion-reducing power [FRAP]) evaluated. In tissue: histology, nonalcoholic disease score (NAS), triglycerides cholesterol content, activities (fatty synthase, acetyl-CoA carboxylase, malic enzyme, glucose-6-phosphate dehydrogenase), related (CPT-1), oxygen species, TBARS, FRAP, glutathione, catalase, glutathione peroxidase, reductase activities. 4-hydroxynonenal, NrF2, NF-κB p65 levels analyzed immunohistochemistry. Results: results showed SRD-fed developed dyslipidemia, damage, (increase key novo synthesis decrease oxidation), lipid peroxidation, stress. Hepatic NrF2 expression significantly decreased increased. Cannabis improved steatosis, peroxidation (improving metabolism), tissue, increased, reduced. Conclusion: present revealed new aspects damage dyslipidemic insulin-resistant rats. demonstrated properties molecular (CBD:THC, lipotoxicity MS.

Язык: Английский

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Exploring the Synergy of Carbon Nanodots in Enhancing Cannabidiol Delivery and Therapeutic Efficacy: A Comprehensive Review

Опубликована: Окт. 23, 2023

The dynamic interaction between carbon nanodots (CNDs) and cannabidiol (CBD) has captured significant attention as an innovative avenue for redefining drug delivery amplifying therapeutic effectiveness. This in-depth review delves into the intricate synergy these two elements, unveiling their profound potential in medicine. Commencing with examination of unique characteristics CNDs techniques governing synthesis, we discuss versatility carriers, highlighting invaluable role advancing CBD delivery. Cannabidiol, a non-psychoactive compound sourced from cannabis, emerged focal point its diverse attributes. Nevertheless, limitations posed by restricted bioavailability susceptibility to degradation pose substantial hindrances realizing full potential. Here, elucidate how amalgamation transcends challenges. We delve mechanisms that underlie this synergy, such augmentation solubility safeguarding against premature breakdown, providing analysis. will also journey you through comprehensive exploration loading onto CNDs, dissecting realms physical encapsulation, covalent bonding, adsorption processes. In summation, combination presents extraordinary opportunity elevate outcomes. synergetic paradigm masterfully tackles pivotal challenges delivery, thereby paving path pioneering medical solutions.

Язык: Английский

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Exploring the Role of the Endocannabinoid System in Chronic Kidney Disease: Implications for Therapeutic Interventions

Journal of Advances in Medicine and Medical Research, Год журнала: 2023, Номер 35(24), С. 14 - 22

Опубликована: Дек. 13, 2023

Aim: Assess alterations in circulating endocannabinoid levels and their potential correlation with the progression of chronic kidney disease. Additionally, study aims to consider implications for clinical use these compounds. Study Design: Descriptive, qualitative, retrospective observational approach, utilizing a methodological framework grounded bibliographic examination publications featured indexed journals. Methodology: An exploration was conducted on academic search platform PubMed, using terms "endocannabinoid system" "kidney disease," chronological filter spanning last 10 years. This yielded 60 articles, which then underwent screening sorting process platform's tools categorize documents based thematic relevance. Results: The exhaustive cannabinoid signaling disease unveils nuanced intricate landscape where distinctive functions CB1 CB2 receptors become apparent. manipulation system arises as potentially efficacious therapeutic approach mitigating injury, substantiated by evidence highlighting its pivotal role homeostasis normal function. Nevertheless, interplays renal physiology demand circumspect methodology formulation interventions, considering varied effects observed different contexts function. Conclusion: interaction between function presents promising avenue, offering valuable insights development innovative approaches treatment diseases.

Язык: Английский

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Prospects in the Use of Cannabis sativa Extracts in Nanoemulsions

BioTech, Год журнала: 2024, Номер 13(4), С. 53 - 53

Опубликована: Дек. 2, 2024

Cannabis sativa plants have been widely investigated for their specific compounds with medicinal properties. These bioactive exert preventive and curative effects on non-communicable infectious diseases. However, C. extracts barely investigated, although they constitute an affordable option to treat human Nonetheless, antioxidant, antimicrobial, immunogenicity associated extracts. Furthermore, innovative extraction methods in combination nanoformulations proposed increase desirable compounds’ availability, distribution, conservation, which can be aided by modern computational tools a transdisciplinary approach. This review aims describe available nanoformulation sativa, as well its known immunogenic activities. Critical points the use of are identified some prospects envisaged.

Язык: Английский

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Green Smoke, Red Flag: Cannabis and the Risk of Orbitopathy and Dermopathy in Thyrotoxicosis

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Май 16, 2023

Background The use of cannabis has been associated with an array multi-systemic physiological effects. However, the medical literature on potential role cannabinoids in management and outcomes thyrotoxicosis remains scarce. We studied association between orbitopathy, dermopathy, length hospital stay for admissions. Methods A thorough analysis was conducted adult hospitalizations 2020 a primary discharge diagnosis thyrotoxicosis, using data from Nationwide Inpatient Sample (NIS). To ensure completeness consistency, missing or incomplete information, as well those involving patients under 18 years age, were excluded study. remaining study sample categorized into two groups based presence absence use, determined by ICD-10-CM/PCS codes. Subtypes confounding factors identified previous defined validated evaluated multivariate regression analysis. focus thyroid while dermopathy average considered secondary outcomes. Results total 7,210 included Among them, 404 (5.6%) 6,806 (94.4%) non-users serving controls. Cannabis users predominantly female (227, 56.3%), which similar to control group (5,263, 73%), they primarily Black descent. Notably, cohort significantly younger than (37.7 ± 1.3 vs. 63.6 0.3). Upon conducting analysis, it found that linked significant increase odds orbitopathy among (AOR: 2.36; 95% CI: 1.12-4.94; P = 0.02). Additionally, history tobacco smoking also correlated higher 1.21; 0.76-1.93; p 0.04). no observed 0.88; 0.51-1.54; 0.65) (IRR: 0.44; 0.58-1.46; 0.40). Conclusion increased thyrotoxicosis. be augmented orbitopathy.

Язык: Английский

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