Life,
Год журнала:
2023,
Номер
13(5), С. 1112 - 1112
Опубликована: Апрель 29, 2023
The
seeds
of
dissected
hogweed
(Heracleum
dissectum
Ledeb.,
Apiaceae)
are
the
source
oil
(HSO),
which
is
still
underexplored
and
requires
careful
chemical
biological
studies.
performed
physico-chemical
analysis
HSO
elucidated
basic
physical
characteristics
revealed
presence
fatty
acids,
essential
components,
pigments,
coumarins.
High-performance
liquid
chromatography
with
photodiode
array
detection
electrospray
ionization
triple
quadrupole
mass
spectrometric
(HPLC-PDA-ESI-tQ-MS/MS)
identified
38
coumarins
that
were
characterized
quantified.
Various
furanocoumarins
major
components
polyphenolics,
including
imperatorin,
phellopterin,
isoimperatorin,
total
coumarin
content
in
varied
from
181.14
to
238.42
mg/mL.
storage
stability
selected
compounds
indicated
their
good
preservation
after
3-year
at
cold
freezing
temperatures.
application
CO2-assisted
effervescence
method
allowed
production
an
nanosuspension,
was
used
a
brain
ischemia
model
rats.
nanosuspension
enhanced
cerebral
hemodynamics
decreased
frequency
necrotic
processes
tissue.
Thus,
H.
coumarins,
promotes
neuroprotection
lesions,
supports
earlier
ethnopharmacological
data.
Frontiers in Natural Products,
Год журнала:
2025,
Номер
3
Опубликована: Янв. 7, 2025
The
increasing
prevalence
of
viral
infections
and
the
emergence
drug-resistant
or
mutant
strains
necessitate
exploration
novel
antiviral
strategies.
Accumulating
evidence
suggests
that
natural
plant
products
have
significant
potential
to
enhance
human
response.
Various
(PNPs)
known
for
their
properties
been
evaluated
ability
modulate
immune
responses
inhibit
infections.
Research
has
focused
on
understanding
mechanisms
by
which
these
PNPs
interact
with
system
complement
existing
therapies.
control
compounds
such
as
alkaloids,
flavonoids,
terpenoids,
polyphenols
promote
cytokine
synthesis,
increase
T-cell
macrophage
activity,
activate
genes.
Studies
investigated
molecular
interactions
between
PNPs,
viruses,
host
cells,
exploring
combining
conventional
drugs
efficacy.
However,
several
challenges
remain,
including
identifying,
characterizing,
standardizing
PNP
extracts,
optimizing
dosages,
improving
bioavailability,
assessing
long-term
safety,
navigating
regulatory
approval.
promising
is
being
explored
develop
new,
effective,
This
review
outlines
a
framework
an
integrative
approach
connect
full
in
combating
health.
By
treatments,
more
effective
sustainable
management
diseases
can
be
achieved.
Biomolecules,
Год журнала:
2023,
Номер
13(7), С. 1105 - 1105
Опубликована: Июль 12, 2023
Betulin
is
a
natural
triterpene,
usually
from
birch
bark,
known
for
its
potential
wound-healing
properties.
Despite
having
wide
range
of
pharmacological
targets,
no
studies
have
proposed
betulin
as
multitarget
compound.
has
protective
effects
against
cardiovascular
and
liver
diseases,
cancer,
diabetes,
oxidative
stress,
inflammation.
It
reduces
postprandial
hyperglycemia
by
inhibiting
α-amylase
α-glucosidase
activity,
combats
tumor
cells
inducing
apoptosis
metastatic
proteins,
modulates
chronic
inflammation
blocking
the
expression
proinflammatory
cytokines
via
modulation
NFκB
MAPKs
pathways.
Given
to
influence
diverse
biological
networks
with
high
target
specificity,
it
can
be
hypothesized
that
may
eventually
become
new
lead
drug
development
because
modify
variety
targets.
The
summarized
research
revealed
beneficial
in
various
diseases
attributed,
at
least
part,
anti-inflammatory
activity.
This
review
focuses
on
sources,
pharmacokinetics,
activity
betulin,
multi-target
signaling
pathways
such
MAPK,
NF-κB,
Nrf2,
which
are
important
regulators
response
stress
body.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 15, 2024
For
the
first
time,
kinetic
thermomagnetic
extraction
is
a
novel
approach
presented
in
this
work.
It
required
application
of
four
distinct
variables:
rotation
speed
(50,
75,
and
100
rpm),
magnetic
field
(0.8,
1.2,
1.6
T),
time
interval
(30,
60,
90
min),
temperature
(45,
55,
65
°C).
Numerous
phytochemical
categories
were
detected
81
crude
chloroform
extracts
green
sweet
bell
pepper
seeds
that
collected,
according
to
analysis.
Nine
discovered
be
linked
coumarin
chemical
class
have
same
two
parameters:
90-minute
duration
55
°C
temperature.
To
enable
their
contents
chemically
separated
chromatographically
purified,
these
containing
chosen.
Four
new
phytocoumarins
been
identified
molecular
structures
distinguished
using
FTIR
spectra,
