Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 789 - 789
Опубликована: Июнь 28, 2024
Bone
defects
caused
by
trauma,
tumor
resection,
and
infections
are
significant
clinical
challenges.
Excessive
reactive
oxygen
species
(ROS)
usually
accumulate
in
the
defect
area,
which
may
impair
function
of
cells
involved
bone
formation,
posing
a
serious
challenge
for
repair.
Due
to
potent
ROS
scavenging
ability,
as
well
potential
anti-inflammatory
immunomodulatory
activities,
antioxidants
play
an
indispensable
role
maintenance
protection
health
have
gained
increasing
attention
recent
years.
This
narrative
review
aims
give
overview
main
research
directions
on
application
antioxidant
compounds
repair
over
past
decade.
In
addition,
positive
effects
various
their
biomaterial
delivery
systems
summarized
provide
new
insights
exploring
antioxidant-based
strategies
The Journal of Gene Medicine,
Год журнала:
2025,
Номер
27(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Purpose
Postmenopausal
osteoporosis
(PMO)
is
mainly
concerned
with
the
imbalance
of
bone
resorption
and
formation.
Icariin
(ICA)
plays
a
vital
role
in
protection.
This
study
investigated
mechanism
ICA
PMO
rats.
Methods
The
rats
were
treated
ovariectomy
(OVX)
ICA.
Bone
structure
parameters
measured
by
Micro‐CT.
BMSCs
obtained
from
normal
rats,
OVX
ICA‐treated
infected
SOST
overexpression
lentivirus,
TWS119,
an
activator
Wnt
pathway,
was
introduced
for
joint
experiment.
binding
ERα
to
promoter
verified.
OVX/ICA
injected
DNA
methyltransferase
inhibitor
5‐Aza‐dC.
Result
increased
mass
decreased
marrow
fat
content
facilitated
osteogenic
differentiation
repressed
adipogenic
BMSCs.
Overexpressing
antagonized
effect
ICA,
whereas
TWS119
rescued
overexpressing
SOST.
reduced
expression
attenuating
ERα.
Methylation
inhibited
promoter.
In
vivo
experiments
confirmed
that
improved
enhancing
methylation.
Conclusion
Overall,
upregulated
methylation
promoter,
thereby
promoting
repressing
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 24, 2023
Osteoporosis
(OP)
and
Dermatoporosis
(DP)
are
expressions
of
the
aging
process
at
skin
bone
levels,
respectively.
Both
conditions
associated
with
increased
morbidity
for
elderly
people,
this
requires
necessary
interventions.
They
share
many
common
risk
factors;
among
these,
vitamin
D
(VD)
deficiency
appears
to
have
a
role.
VD
is
involved
in
either
disease
mechanisms,
which
immunomodulation.
has
been
linked
OP
because
it
inhibits
body's
capacity
absorb
calcium
maintain
optimal
health.
Available
evidence
suggests
that
proper
vitaminosis
also
be
vital
preventing
age-related
issues.
DP
often
seen
individuals,
particularly
those
long-term
sun
exposure
history
chronic
damage.
can
DP,
since
its
involvement
collagen
production,
epidermal
barrier
function,
inflammation
regulation,
wound
healing,
protection.
Aim
review
summarize
most
updated
existing
on
role
development
fragility
syndromes
such
as
possible
benefits
supplementation
simple
harmful
weapon
against
aging.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116954 - 116954
Опубликована: Июнь 20, 2024
Osteoporosis,
characterized
by
compromised
bone
density
and
microarchitecture,
represents
a
significant
global
health
challenge,
particularly
in
aging
populations.
This
comprehensive
review
delves
into
the
intricate
signaling
pathways
implicated
pathogenesis
of
osteoporosis,
providing
valuable
insights
pivotal
role
signal
transduction
maintaining
homeostasis.
The
exploration
encompasses
cellular
such
as
Wnt,
Notch,
JAK/STAT,
NF-κB,
TGF-β,
all
which
play
crucial
roles
remodeling.
dysregulation
these
is
contributing
factor
to
necessitating
profound
understanding
their
complexities
unveil
molecular
mechanisms
underlying
loss.
highlights
pathological
significance
disrupted
emphasizing
how
deviations
impact
functionality
osteoblasts
osteoclasts,
ultimately
resulting
heightened
resorption
formation.
A
nuanced
analysis
crosstalk
between
provided
underscore
relevance
pathophysiology
osteoporosis.
Furthermore,
study
addresses
some
most
long
non-coding
RNAs
(lncRNAs)
associated
with
adding
an
additional
layer
academic
depth
immune
system
involvement
various
types
Finally,
we
propose
that
SKP1
can
serve
potential
biomarker
The American Journal of Chinese Medicine,
Год журнала:
2024,
Номер
52(04), С. 949 - 986
Опубликована: Янв. 1, 2024
Osteoporosis
(OP)
represents
a
substantial
public
health
issue
and
is
associated
with
increasing
rates
of
morbidity
mortality.
It
characterized
by
reduced
bone
mineral
density,
deterioration
tissue
quality,
disruption
the
microarchitecture
bones,
compromised
strength.
These
changes
may
be
attributed
to
following
factors:
intercellular
communication
between
osteoblasts
osteoclasts;
imbalanced
remodeling;
imbalances
osteogenesis
adipogenesis;
in
hormonal
regulation;
angiogenesis;
chronic
inflammation;
oxidative
stress;
intestinal
microbiota
imbalances.
Treating
single
aspect
disease
insufficient
address
its
multifaceted
nature.
In
recent
decades,
traditional
Chinese
medicine
(TCM)
has
shown
great
potential
treatment
OP,
therapeutic
effects
patent
drugs
medicinal
herbs
have
been
scientifically
proven.
TCMs,
which
contain
multiple
components,
can
target
diverse
pathogeneses
OP
through
multitargeted
approach.
Herbs
such
as
XLGB,
JTG,
GSB,
Yinyanghuo,
Gusuibu,
Buguzhi,
Nvzhenzi
are
among
TCMs
that
used
treat
demonstrated
promising
this
context.
They
exert
their
targeting
various
pathways
involved
metabolism.
balance
activity
(bone-forming
cells)
osteoclasts
(bone-resorbing
cells),
they
exhibit
anti-inflammatory,
immunomodulatory,
anti-oxidative,
estrogen-like
functions.
mechanisms
underlie
efficacy
these
management
OP.
Herein,
we
examine
treating
reviewing
previous
clinical
trials
basic
experiments,
mechanism
therapies
provide
evidence
regarding
use
TCM
for
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 29, 2024
Ulcerative
colitis
(UC)
is
a
recurring
inflammatory
bowel
disease,
in
which
oxidative
stress
plays
role
its
progression,
and
regulation
of
the
oxidative/antioxidative
balance
has
been
suggested
as
potential
target
for
treatment
UC.
The
aim
this
study
was
to
evaluate
protective
effect
andrographolide
against
UC
antioxidant
properties
by
modulating
nuclear
factor
erythroid
2-related
2
(Nrf2)/heme
oxygenase-1
(HO-1)
pathway.
Dextran
sulfate
sodium
(DSS)
-induced
mice
LPS-induced
HT29
cell
model
were
established
uncover
mechanisms
andrographolide.
ML385,
Nrf2
inhibitor,
used
both
models
assess
whether
exerts
through
Nrf2/HO-1
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Авг. 26, 2023
Abstract
With
the
discovery
of
intrinsic
enzyme‐like
activity
metal
oxides,
nanozymes
garner
significant
attention
due
to
their
superior
characteristics,
such
as
low
cost,
high
stability,
multi‐enzyme
activity,
and
facile
preparation.
Notably,
in
field
biomedicine,
primarily
focus
on
disease
detection,
antibacterial
properties,
antitumor
effects,
treatment
inflammatory
conditions.
However,
potential
for
application
regenerative
medicine,
which
addresses
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
treatment,
is
garnering
interest
well.
This
review
introduces
an
innovative
strategy
within
realm
medicine.
The
primary
this
approach
lies
facilitation
osteochondral
regeneration
through
modulation
pathological
microenvironment.
catalytic
mechanisms
four
types
representative
are
first
discussed.
microenvironment
inhibiting
followed
by
summarizing
therapy
mechanism
barriers
introduced.
Further,
therapeutic
diseases
included.
To
improve
efficiency
facilitate
clinical
translation,
future
applications
also
discussed
some
challenges
addressed.
