Phenolic compounds in dietary target the regulation of gut microbiota: Role in health and disease

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105107 - 105107

Опубликована: Сен. 1, 2024

Язык: Английский

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Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial

Nutrients, Год журнала: 2024, Номер 16(18), С. 3191 - 3191

Опубликована: Сен. 20, 2024

Background: Consumption of flavonoid-rich orange juice has been shown to reduce adiposity and liver steatosis in murine models diet-induced obesity. However, little is known about the effects whole intake, independent body weight changes, on function individuals with metabolic dysfunction-associated steatotic disease (MASLD). The goal understand direct impact consumption health. Methods: Sixty-two men women aged 30–65 MASLD (Controlled Attenuation Parameter, (CAP) > 275 dB/m) were randomly assigned consume either 400 g oranges or non-citrus fruits daily for 4 weeks. Baseline evaluations included medical assessments, blood tests, composition. Liver health was assessed using transient elastography (FibroScan®) fibrosis, conducted by blinded personnel. This clinical trial registered at ClinicalTrials.gov (NCT05558592). Results: After weeks supplementation, decreased treatment group, 70.9% showing compared 100% controls (p < 0.004), indicating a 30% reduction prevalence. There no significant changes fibrosis plasma enzymes, though gamma glutaril transferase (GGT) levels significantly. Body weight, waist circumference, composition, lipid profile, fasting glucose, insulin, C-reactive protein remained unchanged. Dietary analysis revealed change caloric but vitamins C, A, thiamine, riboflavin increased group. Conclusions: Our findings suggest that phytochemical-rich foods, especially like oranges, may enhance as an adjunct MASLD. notable prevalence occurred independently changes. Further studies are needed investigate long-term supplementation progression identify specific bioactive compounds mechanisms involved.

Язык: Английский

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Does Encapsulation Improve the Bioavailability of Polyphenols in Humans? A Concise Review Based on In Vivo Human Studies

Nutrients, Год журнала: 2024, Номер 16(21), С. 3625 - 3625

Опубликована: Окт. 25, 2024

Polyphenols offer an array of health benefits that can contribute to well-being. Nevertheless, their bioactivity be compromised due low bioavailability. Encapsulation has been explored as a strategy enhance the stability and bioavailability polyphenols. During encapsulation, polyphenols are protected from degradation by wall material acts protective coating. This coating shields harsh physiological conditions digestion, ensuring delivery intestine. However, majority evidence, particularly regarding after is derived in vitro studies. While these studies provide valuable preliminary insights, they cannot definitively confirm effects vivo inability accurately replicate complex gut microbial ecosystem. Consequently, this review seeks evaluate current evidence human elucidate efficacy encapsulation improving polyphenols'

Язык: Английский

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Unveiling roles of beneficial gut bacteria and optimal diets for health

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial bacteria such as Akkermansia muciniphila, Adlercreutzia equolifaciens, Christensenella minuta contribute to metabolic regulation immune support through bioactive metabolites like short-chain fatty acids (SCFAs). Dietary patterns rich prebiotics, fermented foods, plant-based compounds, including polyphenols flavonoids, promote diversity stability. However, challenges individual variability, bioavailability, dietary adherence, the dynamic nature of microbiota remain significant. This review synthesizes current insights into bacteria's emphasizing mechanisms by which interventions modulate microbiota. Additionally, it highlights advancements microbiome-targeted therapies transformative potential personalized nutrition, leveraging profiling artificial intelligence (AI) develop tailored strategies for optimizing health mitigating chronic inflammatory disorders. Addressing these requires multidisciplinary approach that integrates scientific innovation, ethical frameworks, practical implementation strategies.

Язык: Английский

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Historical insights of polyphenols in human health

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 3 - 42

Опубликована: Янв. 1, 2025

Язык: Английский

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