Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Март 5, 2025

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, pivotal myocardial I/R injury. Preventing death during of vital for improving ischemic cardiomyopathy. These multiple forms can occur simultaneously, interact each other, contribute complexity In this review, we aim provide comprehensive summary key molecular mechanisms regulatory patterns involved these five types We will also discuss crosstalk intricate interactions among mechanisms, highlighting interplay between different death. Furthermore, explore specific molecules or targets that participate pathways elucidate their action. It important note manipulating distinct processes may have significant impact on reducing By enhancing researchers' understanding injury, review aims pave way development novel interventions cardio-protection affected by

Язык: Английский

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RGS12 is a target of penehyclidine hydrochloride that enhances oxidative stress and ferroptosis in a model of myocardial ischemia/reperfusion injury by inhibiting the Nrf2 pathway

International Journal of Molecular Medicine, Год журнала: 2025, Номер 55(3)

Опубликована: Янв. 24, 2025

Regulator of G‑protein signaling 12 (RGS12) is a regulatory factor that involved in various physiological processes. However, the role RGS12 myocardial ischemia/reperfusion injury (MIRI) currently remains unclear. The present study established mouse model MIRI by ligating left main coronary artery followed reperfusion. In addition, HL‑1 cells were cultured hypoxic and serum‑free medium, reoxygenation to establish an in vitro cell hypoxia/reoxygenation (H/R). Adenoviruses targeting subsequently used either overexpress or silence expression. was highly expressed both tissues mice with subjected H/R. results from experiments demonstrated knockdown reduced oxidative stress under pathological environment, as indicated decreased reactive oxygen species (ROS) levels malondialdehyde activity increased activities superoxide dismutase catalase. Furthermore, underwent H/R stimulation exhibited ferroptosis, whereas reversed these changes. These showed post‑RGS12 silencing Fe²⁺ lipid ROS decreased, expression glutathione peroxidase 4 cystine transporter solute carrier family 7 member 11 mitochondrial structure improved preventing loss crest. Mechanistically, nuclear erythroid 2‑related 2 (Nrf2) pathway anti‑ferroptosis anti‑oxidative capacities activated knockdown. Conversely, overexpression exerted opposite effects vivo vitro. Notably, it penehyclidine hydrochloride (PHC), known block process, vivo vitro, inhibited therapeutic PHC on MIRI. conclusion, RGS12, target PHC, potentially enhanced progression promoting this effect may involve regulation Nrf2 pathway.

Язык: Английский

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Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction Due to Ischemia–Reperfusion Injury

Antioxidants, Год журнала: 2025, Номер 14(3), С. 340 - 340

Опубликована: Март 14, 2025

Delayed reperfusion of the ischemic heart (I/R) is known to impair recovery cardiac function and produce a wide variety myocardial defects, including ultrastructural damage, metabolic alterations, subcellular Ca2+-handling abnormalities, activation proteases, changes in gene expression. Although I/R injury has been reported induce formation reactive oxygen species (ROS), inflammation, intracellular Ca2+ overload, generation oxidative stress considered play critical role development dysfunction. Increases production superoxide, hydroxyl radicals, oxidants, such as hydrogen peroxide hypochlorous acid, occur hearts subjected injury. In fact, mitochondria are major source excessive ROS due impairment electron transport system well xanthine oxidase NADPH oxidase. Nitric oxide synthase, mainly present endothelium, also activated injury, leading nitric oxide, which, upon combination with superoxide generates nitrosative stress. Alterations function, sarcolemma, sarcoplasmic reticulum activities, mitochondrial phosphorylation, protease simulated exposing oxyradical-generating (xanthine plus oxidase) or H2O2. On other hand, endogenous antioxidants dismutase, catalase, glutathione peroxidase, concentration transcription factor (Nrf2), which modulates expression various antioxidants, depressed hearts. Furthermore, pretreatment catalase N-acetylcysteine, mercaptopropionylglycerine observed attenuate I/R-induced handling Ca2+-regulatory activities; additionally, it found depress improve function. These observations indicate that intimately involved pathological effects different alterations Thus, we faced task developing safe effective agents for upregulating therapy

Язык: Английский

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Mitochondrial biomarkers for airborne particulate matter–associated cardiovascular diseases

Current Opinion in Environmental Science & Health, Год журнала: 2023, Номер 35, С. 100494 - 100494

Опубликована: Июль 23, 2023

Язык: Английский

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The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation

Biomedicines, Год журнала: 2023, Номер 11(6), С. 1676 - 1676

Опубликована: Июнь 9, 2023

ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane ST2L isoforms. The ligand IL-33, which determines the activation numerous intracytoplasmic mediators following binding IL-1RAcP, leading to nuclear signal cardiovascular effect. Differently, released in blood works as decoy receptor, IL-33 blocking IL-33/ST2L interaction. mainly involved maintaining homeostasis and/or alterations different tissues, counterbalance/activation axis typically development fibrosis, tissue damage, inflammation remodeling. has been described clinical reports fundamental prognostic marker patients disease, well for treatment monitoring heart failure; however, further studies are needed better elucidate its role. In this review we reported current knowledge about role coronary artery failure, transplantation, valve pulmonary arterial hypertension, interventions.

Язык: Английский

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Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease

Autonomic Neuroscience, Год журнала: 2023, Номер 251, С. 103137 - 103137

Опубликована: Дек. 7, 2023

Язык: Английский

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Could Tumor Necrosis Factor Serve as a Marker for Cardiovascular Risk Factors and Left Ventricular Hypertrophy in Patients with Early-Onset Coronary Artery Disease?

Diagnostics, Год журнала: 2024, Номер 14(4), С. 449 - 449

Опубликована: Фев. 18, 2024

Introduction: Tumor necrosis factor (TNF), a pro-inflammatory cytokine, can be produced by cardiomyocytes, leading to metabolic disorders in the myocardium. The objective of this study was assess relationship between plasma levels TNF cytokine and presence known biochemical clinical risk factors for cardiovascular disease, along with parameters cardiac morphology patients diagnosed coronary artery disease (CAD) at young age. Materials Methods: group included 75 men aged up 50 years 25 women 55 years. concentration measured use ELISA assay. Echocardiography electrocardiographic examinations were performed all patients. Results: We observed positive correlations BMI ratio, weight, waist hip circumference. also found negative HDL ApoA concentrations, ApoB/ApoA1 Apo B, IL6, LDL TG concentrations. These results suggest an association higher concentrations components syndrome, including dyslipidemia. may potential impaired diastolic function. Conclusions: While useful diagnosing certain risks CAD patients, measurement cannot used as surrogate test echocardiography.

Язык: Английский

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The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Diagnostics, Год журнала: 2023, Номер 13(22), С. 3398 - 3398

Опубликована: Ноя. 7, 2023

Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests potential involvement renin-angiotensin system (RAS) in pathogenesis progression these conditions. RAS is multicomponent cascade, primarily known for role regulating blood pressure fluid balance. All components play an important controlling inflammation other responses. Angiotensin II, main effector, acts on two essential receptors: Receptor 1 2 (AT1R AT2R). A disturbance axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers signaling cascades involved inflammation, fibrosis tissue remodeling. Experimental studies have demonstrated presence various cutaneous cells cells, further emphasizing contribution AI processes skin. Furthermore, investigations highlighted components, beyond angiotensin-converting enzyme (ACE) Ang that may contribute pathophysiology AIDD. Alternative pathways involving ACE2, receptors Ang-(1-7) been implicated homeostasis within microenvironment. Understanding intricate AIDD provide novel therapeutic opportunities. Targeting specific RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative pathway modulators, could potentially ameliorate inflammatory responses, reduce damage lessen disease manifestations. Further research warranted outline exact mechanisms underlying RAS-mediated dysregulation This abstract aims concise overview interplay between Therefore, we elaborate systematic review challenge AIDD, psoriasis, systemic sclerosis, vitiligo, lupus erythematosus more.

Язык: Английский

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Myocardial tissue expression of mRNA and preoperative neutrophil-lymphocyte ratio in children undergoing congenital heart surgery

Translational Pediatrics, Год журнала: 2024, Номер 13(2), С. 248 - 259

Опубликована: Фев. 1, 2024

Valdano Manuel, Leonardo A. Miana, Miriam Helena Fonseca-Alaniz, Gabriel Carrillo Hernan, Davi Freitas Tenório, Celestino Bado, Mariana Lombardi Peres de Carvalho, Matheus Meirelles, João Paulo Mota Telles, Juliano Gomes Penha, Carla Tanamati, Luiz Fernando Caneo, José Eduardo Krieger, Fábio Biscegli Jatene, Marcelo Jatene

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Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 10, 2024

Background Although Shen Gui capsules (SGCP) are widely used as an adjuvant treatment for chronic heart failure (CHF), their clinical efficacy and safety remain controversial. Purpose To assess the of SGCP in CHF through a systematic review meta-analysis, to provide high-quality evidence evidence-based medicine. Methods Seven databases were searched randomized controlled trials (RCTs) assessing CHF, from inception 9 January 2023. RCT quality was evaluated using Cochrane Handbook Evaluation Intervention Systems risk bias Grading Recommendations Assessment, Development, Evaluation. A meta-analysis with subgroup sensitivity analyses performed Review Manager 5.4 Stata 12. Results Nine RCTs representing 888 patients included review. Meta-analysis revealed that combined conventional therapy is more advantageous improving left ventricular ejection fraction [LVEF; mean difference (MD) = 5.26, 95% confidence interval (CI) (3.78, 6.74), p < 0.0000] increasing effective rate [relative (RR) 1.21, 95%CI (1.14, 1.29), 0.001] compared alone. The experimental also reduced brain natriuretic peptide [MD −100.15, (−157.83, −42.47), 0.0007], end-diastolic diameter −1.93, (−3.22, −0.64), 0.003], hypersensitive C-reactive protein −2.70, (−3.12,−2.28), control group. However, there not statistically significant tumor necrosis factor-α −14.16, (−34.04, 5.73), 0.16] or end-systolic −1.56, (−3.13, 0.01), 0.05]. Nor between-groups incidence adverse events ( > 0.05). Conclusion can improve LVEF increase safely treat CHF. further studies needed confirm these findings, due overall low this literature. Clinical Trial Registration: https://www.crd.york.ac.uk/PROSPERO/logout.php , PROSPERO [CRD42023390409].

Язык: Английский

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