Neurological Sciences,
Год журнала:
2024,
Номер
45(7), С. 3093 - 3105
Опубликована: Фев. 21, 2024
Post-sepsis
psychiatric
disorder,
encompassing
anxiety,
depression,
post-traumatic
stress
disorder
and
delirium,
is
a
highly
prevalent
complication
secondary
to
sepsis,
resulting
in
marked
increase
long-term
mortality
among
affected
patients.
Regrettably,
impairment
associated
with
sepsis
frequently
disregarded
by
clinicians.
This
review
aims
summarize
recent
advancements
the
understanding
of
pathophysiology,
prevention,
treatment
post-sepsis
mental
including
coronavirus
disease
2019-related
impairment.
The
pathophysiology
complex
known
involve
blood-brain
barrier
disruption,
overactivation
hypothalamic-pituitary-adrenal
axis,
neuroinflammation,
oxidative
stress,
neurotransmitter
dysfunction,
programmed
cell
death,
impaired
neuroplasticity.
No
unified
diagnostic
criteria
for
this
are
currently
available;
however,
screening
scales
often
applied
its
assessment.
Modifiable
risk
factors
include
number
experienced
traumatic
memories,
length
ICU
stay,
level
albumin,
use
vasopressors
or
inotropes,
daily
activity
function
after
cumulative
dose
dobutamine.
To
contribute
prevention
it
may
be
beneficial
implement
targeted
interventions
these
modifiable
factors.
Specific
therapies
condition
remain
scarce.
Nevertheless,
non-pharmacological
approaches,
such
as
comprehensive
nursing
care,
provide
promising
avenue
treating
following
sepsis.
In
addition,
although
several
therapeutic
drugs
have
shown
preliminary
efficacy
animal
models,
further
confirmation
their
potential
required
through
follow-up
clinical
studies.
Heliyon,
Год журнала:
2023,
Номер
9(9), С. e19975 - e19975
Опубликована: Сен. 1, 2023
ObjectiveThe
mechanisms
of
chondrocytes
ferroptosis
in
osteoarthritis
(OA)
have
not
yet
been
fully
elucidated.
This
study
aimed
to
identify
key
related
genes
(FRGs)
involved
ferroptosis.MethodsLASSO,
SVM-RFE,
and
receiver
operating
characteristic
curve
(ROC)
were
performed
screen
differentially
expressed
FRGs
(DEFRGs).
Functional
analyses
conducted
using
GO,
KEGG
analyses.
Unsupervised
clustering
analysis
was
used
patterns.
The
CeRNA
network
constructed
predict
the
upstream
miRNAs
lncRNAs.
Finally,
we
validated
role
EGFR
vivo
vitro
experiments.ResultsA
total
42
DEFRGs
identified
between
OA
normal
cartilages.
GO
indicated
that
these
significantly
engaged
biological
processes
pathways,
such
as
cellular
response
oxidative
stress,
positive
regulation
programmed
cell
death,
MAPK
PI3K-Akt
signaling
pathways.
Moreover,
four
DEFRGs,
including
ACSF2,
AURKA,
EGFR,
KLHL24,
considered
potential
biomarkers
OA.
two
distinct
patterns
determined,
a
882
which
might
participate
extracellular
matrix
degradation
inflammatory
response.
In
addition,
showed
could
be
competitively
regulated
by
3
lncRNAs
4
miRNAs.
Significantly,
expression
downregulated
human
cartilages,
mouse
model,
erastin
induced
chondrocytes.
inhibition
induce
occurrence
ECM
reversed
addition
Ferrostatin-1.ConclusionOur
has
KLHL24
ferroptosis-related
Furthermore,
preliminary
investigation
into
regulating
ferroptosis.
These
findings
offer
novel
insights
molecular
underlying
Neurological Sciences,
Год журнала:
2024,
Номер
45(7), С. 3093 - 3105
Опубликована: Фев. 21, 2024
Post-sepsis
psychiatric
disorder,
encompassing
anxiety,
depression,
post-traumatic
stress
disorder
and
delirium,
is
a
highly
prevalent
complication
secondary
to
sepsis,
resulting
in
marked
increase
long-term
mortality
among
affected
patients.
Regrettably,
impairment
associated
with
sepsis
frequently
disregarded
by
clinicians.
This
review
aims
summarize
recent
advancements
the
understanding
of
pathophysiology,
prevention,
treatment
post-sepsis
mental
including
coronavirus
disease
2019-related
impairment.
The
pathophysiology
complex
known
involve
blood-brain
barrier
disruption,
overactivation
hypothalamic-pituitary-adrenal
axis,
neuroinflammation,
oxidative
stress,
neurotransmitter
dysfunction,
programmed
cell
death,
impaired
neuroplasticity.
No
unified
diagnostic
criteria
for
this
are
currently
available;
however,
screening
scales
often
applied
its
assessment.
Modifiable
risk
factors
include
number
experienced
traumatic
memories,
length
ICU
stay,
level
albumin,
use
vasopressors
or
inotropes,
daily
activity
function
after
cumulative
dose
dobutamine.
To
contribute
prevention
it
may
be
beneficial
implement
targeted
interventions
these
modifiable
factors.
Specific
therapies
condition
remain
scarce.
Nevertheless,
non-pharmacological
approaches,
such
as
comprehensive
nursing
care,
provide
promising
avenue
treating
following
sepsis.
In
addition,
although
several
therapeutic
drugs
have
shown
preliminary
efficacy
animal
models,
further
confirmation
their
potential
required
through
follow-up
clinical
studies.
