Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment DOI Creative Commons

Dayong Li,

Xujie Zhang,

Yuru Lu

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 3093 - 3105

Published: Feb. 21, 2024

Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in marked increase long-term mortality among affected patients. Regrettably, impairment associated with sepsis frequently disregarded by clinicians. This review aims summarize recent advancements the understanding of pathophysiology, prevention, treatment post-sepsis mental including coronavirus disease 2019-related impairment. The pathophysiology complex known involve blood-brain barrier disruption, overactivation hypothalamic-pituitary-adrenal axis, neuroinflammation, oxidative stress, neurotransmitter dysfunction, programmed cell death, impaired neuroplasticity. No unified diagnostic criteria for this are currently available; however, screening scales often applied its assessment. Modifiable risk factors include number experienced traumatic memories, length ICU stay, level albumin, use vasopressors or inotropes, daily activity function after cumulative dose dobutamine. To contribute prevention it may be beneficial implement targeted interventions these modifiable factors. Specific therapies condition remain scarce. Nevertheless, non-pharmacological approaches, such as comprehensive nursing care, provide promising avenue treating following sepsis. In addition, although several therapeutic drugs have shown preliminary efficacy animal models, further confirmation their potential required through follow-up clinical studies.

Language: Английский

The interplay between autophagy and programmed cell death in osteoarthritis: insights into mechanisms and therapeutic targets DOI
Hong Wang, Jing Zhou, Yifan Lu

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro DOI

Sudhansu Sekhar Moharana,

Sumit Mallick, Jamie M. Pinto

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 12, 2025

Language: Английский

Citations

0
Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study DOI Creative Commons

Hong Sun,

Guoxuan Peng,

Kunhao Chen

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19975 - e19975

Published: Sept. 1, 2023

ObjectiveThe mechanisms of chondrocytes ferroptosis in osteoarthritis (OA) have not yet been fully elucidated. This study aimed to identify key related genes (FRGs) involved ferroptosis.MethodsLASSO, SVM-RFE, and receiver operating characteristic curve (ROC) were performed screen differentially expressed FRGs (DEFRGs). Functional analyses conducted using GO, KEGG analyses. Unsupervised clustering analysis was used patterns. The CeRNA network constructed predict the upstream miRNAs lncRNAs. Finally, we validated role EGFR vivo vitro experiments.ResultsA total 42 DEFRGs identified between OA normal cartilages. GO indicated that these significantly engaged biological processes pathways, such as cellular response oxidative stress, positive regulation programmed cell death, MAPK PI3K-Akt signaling pathways. Moreover, four DEFRGs, including ACSF2, AURKA, EGFR, KLHL24, considered potential biomarkers OA. two distinct patterns determined, a 882 which might participate extracellular matrix degradation inflammatory response. In addition, showed could be competitively regulated by 3 lncRNAs 4 miRNAs. Significantly, expression downregulated human cartilages, mouse model, erastin induced chondrocytes. inhibition induce occurrence ECM reversed addition Ferrostatin-1.ConclusionOur has KLHL24 ferroptosis-related Furthermore, preliminary investigation into regulating ferroptosis. These findings offer novel insights molecular underlying

Language: Английский

Citations

9
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement DOI
Yifan Wu, Zhenyu Shen,

Yong Gou

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 390, P. 110877 - 110877

Published: Jan. 1, 2024

Language: Английский

Citations

3
Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment DOI Creative Commons

Dayong Li,

Xujie Zhang,

Yuru Lu

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 3093 - 3105

Published: Feb. 21, 2024

Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in marked increase long-term mortality among affected patients. Regrettably, impairment associated with sepsis frequently disregarded by clinicians. This review aims summarize recent advancements the understanding of pathophysiology, prevention, treatment post-sepsis mental including coronavirus disease 2019-related impairment. The pathophysiology complex known involve blood-brain barrier disruption, overactivation hypothalamic-pituitary-adrenal axis, neuroinflammation, oxidative stress, neurotransmitter dysfunction, programmed cell death, impaired neuroplasticity. No unified diagnostic criteria for this are currently available; however, screening scales often applied its assessment. Modifiable risk factors include number experienced traumatic memories, length ICU stay, level albumin, use vasopressors or inotropes, daily activity function after cumulative dose dobutamine. To contribute prevention it may be beneficial implement targeted interventions these modifiable factors. Specific therapies condition remain scarce. Nevertheless, non-pharmacological approaches, such as comprehensive nursing care, provide promising avenue treating following sepsis. In addition, although several therapeutic drugs have shown preliminary efficacy animal models, further confirmation their potential required through follow-up clinical studies.

Language: Английский

Citations

3