Cosmetics,
Год журнала:
2025,
Номер
12(2), С. 57 - 57
Опубликована: Март 25, 2025
The
skin
is
continuously
exposed
to
environmental
changes,
rendering
it
vulnerable
damage
from
external
stressors
that
contribute
premature
aging.
This
study
aims
explore
longevity
pathways
stimulated
by
a
rose
extract
(RE)
derived
petals.
Human
keratinocytes
treated
with
RE
exhibited
significant
increase
in
NRF2
(NF-E2-related
factor
2;
≈2–4%
of
induction)
and
LAMP2A
(Lysosome-Associated
Membrane
Protein
2A;
≈6–12%
levels.
presence
significantly
mitigated
the
carbonylation
levels
(≈34–37%
protection)
number
labeled
P16INK4A
cells
(≈60–72%
protection),
associated
proliferation
arrest,
both
induced
exposure
BAP
(Benzo[a]pyrene)
coupled
UV-A
(Ultraviolet
A)
irradiation.
beneficial
effects
mediated
were
inhibited
Compound
C,
specific
AMPK
inhibitor
(AMP-activated
protein
kinase).
involvement
pathway
mediating
has
been
confirmed
assessing
its
activation
through
evaluation
phosphorylation
state
which
was
elevated
compared
stress
condition.
In
conclusion,
enhances
antioxidant
defenses
promotes
autophagy.
dual
action,
RE,
helps
protect
oxidative
senescence
while
maintaining
proteostasis,
integrity,
cellular
under
pollution-induced
(BAP
+
UV-A).
These
findings
highlight
potential
mitigating
age-related
changes
modulation
pathways.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13874 - 13874
Опубликована: Сен. 9, 2023
Phenolic
compounds
or
polyphenols
are
among
the
most
common
of
secondary
metabolism
in
plants.
Their
biosynthesis
is
characteristic
all
plant
cells
and
carried
out
with
participation
shikimate
acetate-malonate
pathways.
In
this
case,
various
structures
formed,
such
as
phenylpropanoids,
flavonoids,
oligomeric
polymeric
phenolic
nature.
number
already
exceeds
10,000.
The
diversity
phenolics
affects
their
biological
activity
functional
role.
Most
representatives
characterized
by
interaction
reactive
oxygen
species,
which
manifests
itself
not
only
plants
but
also
human
body,
where
they
enter
through
food
chains.
Having
a
high
activity,
successfully
used
medicines
nutritional
supplements
for
health
population.
accumulation
depend
on
many
factors,
including
physiological-biochemical,
molecular-genetic,
environmental
factors.
review,
we
present
latest
literature
data
structure
classes
compounds,
antioxidant
biosynthesis,
molecular
genetic
aspects
(genes
transfactors).
Since
grow
significant
changes
planet,
response
to
action
abiotic
factors
(light,
UV
radiation,
temperature,
heavy
metals)
at
level
composition
these
metabolites,
well
metabolic
regulation,
considered.
Information
given
about
important
necessary
components
nutrition
pharmaceutically
valuable
substances
Proposals
promising
areas
research
development
field
presented.
Molecules,
Год журнала:
2024,
Номер
29(4), С. 865 - 865
Опубликована: Фев. 15, 2024
The
biochemical
characteristics
of
polyphenols
contribute
to
their
numerous
advantageous
impacts
on
human
health.
existing
research
suggests
that
plant
phenolics,
whether
consumed
orally
or
applied
directly
the
skin,
can
be
beneficial
in
alleviating
symptoms
and
avoiding
development
many
skin
disorders.
Phenolic
compounds,
which
are
both
harmless
naturally
present,
exhibit
significant
potential
terms
counteracting
effects
damage,
aging,
diseases,
wounds,
burns.
Moreover,
play
a
preventive
role
possess
ability
delay
progression
several
disorders,
ranging
from
small
discomforting
severe
potentially
life-threatening
ones.
This
article
provides
concise
overview
recent
therapeutic
application
for
conditions.
It
specifically
highlights
studies
have
investigated
clinical
trials
use
polyphenol-based
nanoformulations
treatment
different
ailments.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(1), С. 126 - 126
Опубликована: Янв. 18, 2024
Resveratrol
is
a
polyphenolic
compound
that
has
gained
considerable
attention
in
the
past
decade
due
to
its
multifaceted
therapeutic
potential,
including
anti-inflammatory
and
anticancer
properties.
However,
efficacy
impeded
by
low
water
solubility,
dose-limiting
toxicity,
bioavailability,
rapid
hepatic
metabolism.
To
overcome
these
hurdles,
various
nanoparticles
such
as
organic
inorganic
nanoparticles,
liposomes,
polymeric
dendrimers,
solid
lipid
gold
zinc
oxide
zeolitic
imidazolate
frameworks,
carbon
nanotubes,
bioactive
glass
mesoporous
were
employed
deliver
resveratrol,
enhancing
against
types
of
cancer.
Resveratrol-loaded
nanoparticle
or
resveratrol-conjugated
administration
exhibits
excellent
potency
compared
free
resveratrol.
This
review
highlights
latest
developments
nanoparticle-based
delivery
systems
for
focusing
on
potential
limitations
associated
with
compound’s
bioavailability
effectiveness.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 370 - 370
Опубликована: Янв. 4, 2025
This
study
examines
the
chemical
composition,
antioxidant
properties,
and
urease
inhibitory
effects
of
Hyoscyamus
muticus
L.
subsp.
falezlez
(Coss.)
Maire.
Using
LC-ESI-MS/MS,
19
distinct
phenolic
compounds
were
identified,
with
chlorogenic
acid
being
most
abundant.
The
ethanol
extract
demonstrated
notable
activity,
highlighting
its
potential
for
therapeutic
use.
Urease
inhibition
assays
revealed
a
remarkable
91.35%
by
H.
extract,
an
IC50
value
5.6
±
1.20
μg/mL,
indicating
promising
role
in
addressing
conditions
linked
to
activity.
Molecular
docking
studies
further
investigated
interaction
between
urease,
identifying
hyperoside
as
leading
candidate,
binding
energy
−7.9
kcal/mol.
Other
compounds,
such
rutin,
luteolin,
apigenin,
kaempferol,
hesperetin,
acid,
rosmarinic
also
significant
affinities,
suggesting
their
disrupt
function.
These
findings
highlight
source
natural
bioactive
offering
avenues
development
novel
treatments
urease-related
disorders
oxidative
stress.
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2023,
Номер
12(1)
Опубликована: Май 15, 2023
Abstract
Background
Flavonols
are
phytoconstituents
of
biological
and
medicinal
importance.
In
addition
to
functioning
as
antioxidants,
flavonols
may
play
a
role
in
antagonizing
diabetes,
cancer,
cardiovascular
disease,
viral
bacterial
diseases.
Quercetin,
myricetin,
kaempferol,
fisetin
the
major
dietary
flavonols.
Quercetin
is
potent
scavenger
free
radicals,
providing
protection
from
radical
damage
oxidation-associated
Main
body
abstract
An
extensive
literature
review
specific
databases
(e.g.,
Pubmed,
google
scholar,
science
direct)
were
conducted
using
keywords
“flavonol,”
“quercetin,”
“antidiabetic,”
“antiviral,”
“anticancer,”
“myricetin.”
Some
studies
concluded
that
quercetin
promising
antioxidant
agent
while
kaempferol
could
be
effective
against
human
gastric
cancer.
addition,
prevents
apoptosis
pancreatic
beta-cells
via
boosting
function
survival
rate
beta-cells,
leading
increased
insulin
secretion.
also
show
potential
alternatives
conventional
antibiotics,
restricting
infection
by
envelope
proteins
block
entry.
Short
conclusion
There
substantial
scientific
evidence
high
consumption
associated
with
reduced
risk
cancer
coronary
diseases,
alleviation,
tumor
growth
prevention,
secretion
improvement,
among
other
diverse
health
benefits.
Nevertheless,
more
required
determine
appropriate
concentration,
dose,
type
flavonol
for
particular
condition
prevent
any
adverse
side
effects.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 209 - 209
Опубликована: Фев. 4, 2025
This
study
conducted
a
literature
review
by
searching
for
articles
related
to
the
treatment
of
skin
infections/wrinkles
using
nano-delivery
systems
containing
natural
compounds.
The
search
was
in
various
databases
published
last
10
years,
with
strict
inclusion
and
exclusion
criteria.
Of
490
found,
40
were
considered
relevant.
Acne
vulgaris
is
common
dermatological
disorder
characterised
inflammation
sebaceous
glands,
often
resulting
development
pimples,
cysts,
scarring.
Conventional
treatments,
including
antibiotics
topical
retinoids,
frequently
demonstrate
limitations
such
as
side
effects,
resistance,
insufficient
absorption.
Recent
advancements
nanotechnology
have
enabled
creation
innovative
drug-delivery
that
enhance
effectiveness
reduce
adverse
effects
anti-acne
medications.
Polyphenols
flavonoids,
bioactive
compounds
notable
anti-inflammatory,
antioxidant,
antibacterial
properties,
are
recognised
their
therapeutic
acne
treatment.
However,
practical
application
hindered
solubility,
stability,
bioavailability.
incorporation
these
into
nanoparticle-based
delivery
has
shown
promise
resolving
challenges.
Various
nanoparticle
platforms,
lipid-based
nanoparticles,
polymeric
solid
lipid
evaluated
ability
improve
controlled
release,
targeted
polyphenols
flavonoids
skin.
advent
polyphenol
flavonoid-loaded
nanoparticles
marks
new
therapy
era.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(4), С. 1951 - 1970
Опубликована: Фев. 15, 2024
Abstract
The
herb
Sophora
flavescens
displays
anti‐inflammatory
activity
and
can
provide
a
source
of
antipsoriatic
medications.
We
aimed
to
evaluate
whether
S.
extracts
compounds
relieve
psoriasiform
inflammation.
ability
flavonoids
(maackiain,
sophoraflavanone
G,
leachianone
A)
alkaloids
(matrine,
oxymatrine)
isolated
from
inhibit
production
cytokine/chemokines
was
examined
in
keratinocytes
macrophages.
Physicochemical
properties
skin
absorption
were
determined
by
silico
molecular
modeling
the
vitro
permeation
test
(IVPT)
establish
structure‐permeation
relationship
(SPR).
ethyl
acetate
extract
exhibited
higher
inhibition
interleukin
(IL)‐6,
IL‐8,
CXCL1
tumor
necrosis
factor‐α‐stimulated
compared
ethanol
water
extracts.
demonstrated
cytokine/chemokine
than
alkaloids,
with
prenylated
flavanones
(sophoraflavanone
led
highest
suppression.
Flavonoids
exerted
effects
via
extracellular
signal‐regulated
kinase,
p38,
activator
protein‐1,
nuclear
factor‐κB
signaling
pathways.
In
IVPT,
prenylation
flavanone
skeleton
significantly
promoted
0.01
0.22
nmol/mg
G
vs.
eriodictyol).
Further
methoxylation
(leachianone
elevated
2.65
nmol/mg.
Topical
A
reduced
epidermal
thickness
IMQ‐treated
mice
47%,
inhibited
cutaneous
scaling
overexpression
at
comparable
levels
commercial
betamethasone
product.
Thus,
may
enable
design
novel
agents.
Foods,
Год журнала:
2024,
Номер
13(4), С. 560 - 560
Опубликована: Фев. 12, 2024
Sea
buckthorn
(Hippophaë
rhamnoides
L.),
as
one
of
the
Elaeagnaceae
family,
has
significant
function
anti-tumor,
anti-inflammation,
anti-oxidation,
and
other
physiological
activities.
High
hydrostatic
pressure
(HHP)
extraction
advantages
being
easy
efficient,
while
maintaining
biological
activity.
In
this
study,
sea
flavonoid
(SBF)
was
extracted
with
HHP
purified
(PSBF)
isolated
by
AB-8
macroporous
resin
column.
HPLC
analysis
used
to
quantified
them.
addition,
effect
anti-allergy
in
RBL-2H3
cells
SBF,
PSBF,
their
compounds
evaluated.
The
results
demonstrate
conditions
for
obtaining
maximum
amount
SBF:
415
MPa
10
min,
72%
ethanol
concentration,
a
liquid
solid
ratio
40
mL/g,
which
increased
purity
from
1.46%
13.26%.
Both
SBF
PSBF
included
rutin,
quercitrin,
quercetin,
isorhamnetin,
kaempferol.
kaempferol,
could
regulate
Th1/Th2
cytokine
balance.
Moreover,
extracellular
Ca2+
influx
reduced
quercitrin
PSBF.
Furthermore,
iso-rhamnetin,
also
inhibit
P-p38
P-JNK
expression,
thereby
suppressing
phosphorylation
MAPK
signaling
pathways.
Overall,
is
effective
relieving
food
allergy
might
be
promising
anti-allergic
therapeutic
agent.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 4202 - 4229
Опубликована: Июнь 26, 2024
Abstract
Glucolipid
metabolism
disorder
(GLMD)
is
a
complex
chronic
disease
characterized
by
glucose
and
lipid
disorders
with
diverse
etiology
rapidly
increasing
incidence.
Many
studies
have
identified
the
role
of
flavonoids
in
ameliorating
GLMD,
mechanisms
related
to
peroxisome
proliferator‐activated
receptors,
nuclear
factor
kappa‐B,
AMP‐activated
protein
kinase,
(erythroid‐derived
2)‐like
2,
transporter
type
4,
phosphatidylinositol‐3‐kinase/protein
kinase
B
pathway.
However,
comprehensive
summary
flavonoid
effects
on
GLMD
lacking.
This
study
reviewed
roles
natural
different
structures
treatment
reported
globally
past
5
years
provides
reference
for
developing
as
drugs
treating
GLMD.
