Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review

Nutrients, Год журнала: 2023, Номер 15(12), С. 2749 - 2749

Опубликована: Июнь 14, 2023

The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed high-sugar drinks, candy, sweets, fried conventionally raised animal products, high-fat dairy and high-fructose products. present review aims to describe the effect on metabolism, inflammation, antioxidant status; impact gut microbiota mitochondrial fitness; cardiovascular health, mental cancer; sanitary cost diet. To achieve this goal, consensus critical was conducted using primary sources, such as scientific articles, secondary including bibliographic indexes, databases, web pages. Scopus, Embase, Science Direct, Sports Discuss, ResearchGate, Web were used complete assignment. MeSH-compliant keywords “Western diet”, “inflammation”, “metabolic health”, fitness”, “heart disease”, “cancer”, “oxidative stress”, “mental “metabolism” used. following exclusion criteria applied: (i) studies with inappropriate or irrelevant topics, not germane review’s focus; (ii) Ph.D. dissertations, proceedings conferences, unpublished studies. This information will allow for better comprehension nutritional behavior its an individual’s metabolism well national systems. Finally, practical applications derived from are made.

Язык: Английский

---

Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2488 - 2488

Опубликована: Сен. 7, 2023

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated the pathogenesis various brain diseases, including neurodegenerative disorders, stroke, psychiatric illnesses. This review paper provides comprehensive overview intricate relationship between disease, focusing on underlying pathological mechanisms exploring potential therapeutic opportunities. The covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, dynamics, calcium dysregulation, reactive oxygen species generation context disease. Additionally, it discusses emerging strategies targeting dysfunction, protective agents, metabolic modulators, gene therapy approaches. By critically analysing existing literature recent advancements, this aims to enhance our understanding multifaceted disease shed light novel interventions.

Язык: Английский

---

New Insights and Potential Therapeutic Interventions in Metabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10672 - 10672

Опубликована: Июнь 26, 2023

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development new techniques insights has led to a deeper understanding mechanisms underlying these conditions opened up avenues for diagnosis treatment. In this review, we discussed rise diseases, especially Western countries, genetical, psychological, behavioral basis role nutrition physical activity single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, cell-based therapies diseases. Finally, practical applications derived from information are made.

Язык: Английский

---

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

Mitochondrion, Год журнала: 2023, Номер 72, С. 33 - 58

Опубликована: Июль 13, 2023

Язык: Английский

---

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Май 21, 2024

A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during process of tumorigenesis, even in presence abundant oxygen, shifting main pathway energy metabolism from tricarboxylic acid cycle to aerobic glycolysis. Recent studies have unveiled dynamic transfer mitochondria within tumor microenvironment, not only between but also and stromal cells, immune others. In this review, we explore pathways mechanisms mitochondrial as well how these activities promote aggressiveness, chemotherapy resistance, evasion. Further, discuss research progress potential clinical significance targeting phenomena. We highlight therapeutic intercellular a future anti-cancer strategy enhancing cell-mediated immunotherapy.

Язык: Английский

---

Mitochondrial extracellular vesicles, autoimmunity and myocarditis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 14, 2024

For many decades viral infections have been suspected as ‘triggers’ of autoimmune disease, but mechanisms for how this could occur difficult to establish. Recent studies shown that are commonly associated with myocarditis and other diseases such coxsackievirus B3 (CVB3) SARS-CoV-2 target mitochondria released from cells in mitochondrial vesicles able activate the innate immune response. Studies Toll-like receptor (TLR)4 inflammasome pathway activated by components. Autoreactivity against cardiac myosin heart-specific responses after infection viruses where heart is not primary site (e.g., CVB3, SARS-CoV-2) may because has highest density body. Evidence exists autoantibodies antigens patients dilated cardiomyopathy. Defects tolerance like regulator gene (AIRE) further increase likelihood autoreactivity leading disease. The focus review summarize current literature regarding role production extracellular containing virus development myocarditis.

Язык: Английский

---

Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Май 24, 2024

Abstract Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation healthy mitochondria into stressed/injured recipient cells, contributing to restoration bioenergetic profile and cell viability, reduction inflammatory processes normalisation calcium dynamics. Recent evidence has shown that MT can occur through multiple cellular structures mechanisms: tunneling nanotubes (TNTs), via gap junctions (GJs), mediated by extracellular vesicles (EVs) other mechanisms (cell fusion, extrusion migrasome-mediated mitocytosis) in different contexts, such as under physiological (tissue homeostasis stemness maintenance) pathological conditions (hypoxia, inflammation cancer). As Mesenchimal Stromal/ Stem Cells (MSC)-mediated emerged critical regulatory restorative mechanism for tissue regeneration damage repair recent years, its potential stem therapy received increasing attention. In particular, therapeutic role MSCs been reported several articles, suggesting enhance after injury membrane vesicle release. For these reasons, this review, we will discuss MSCs-mediated effects on diseases neuronal, ischaemic, vascular pulmonary diseases. Therefore, understanding molecular demonstrating efficacy could be an important milestone lays foundation future clinical trials.

Язык: Английский

---

Mitochondrial signaling pathways and their role in cancer drug resistance

Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329

Опубликована: Авг. 5, 2024

Язык: Английский

---

Hormonal orchestra: mastering mitochondria's role in health and disease

Endocrine, Год журнала: 2024, Номер 86(3), С. 903 - 929

Опубликована: Авг. 22, 2024

Язык: Английский

---

Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15788 - 15788

Опубликована: Окт. 31, 2023

Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus intense preclinical research and clinical implementation for decades. MSCs multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors exert immunoregulatory functions promoting homeostasis resolution injury/inflammation. The main include modulation immune cells (macrophages, neutrophils, lymphocytes), secretion antimicrobial peptides, transfer mitochondria (Mt) injured cells. These actions can be enhanced by priming (i.e., licensing) prior exposure deleterious microenvironments. Preclinical evidence suggests that therapeutic a variety pathological states, including cardiac, respiratory, hepatic, renal, neurological diseases. One key emerging is improvement mitochondrial tissues enhancing quality control (MQC). Recent advances understanding cellular MQC, biogenesis, mitophagy, fission, fusion, helped uncover how enhance these processes. Specifically, suggested regulate peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α)-dependent Parkin-dependent Mitofusins (Mfn1/2) or Dynamin Related Protein-1 (Drp1)-mediated fission/fusion. In addition, previous studies also verified from through tunneling nanotubes via microvesicular transport. Combined, improve functions, thereby contributing injury inflammation. Thus, uncovering affect MQC opens new avenues organ injury, transplantation MSC-derived might represent attractive approach.

Язык: Английский

---