Signature of click chemistry in advanced techniques for cancer therapeutics

RSC Advances, Год журнала: 2025, Номер 15(14), С. 10583 - 10601

Опубликована: Янв. 1, 2025

This review focuses mainly on the signature of click chemistry (CuAAC and SPAAC) in advanced techniques for cancer therapeutics.

Язык: Английский

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Emerging trends in permeation-enhancing technologies for oral peptide delivery

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111170 - 111170

Опубликована: Апрель 1, 2025

Язык: Английский

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Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma

Human Cell, Год журнала: 2025, Номер 38(3)

Опубликована: Апрель 19, 2025

Язык: Английский

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Milk Extracellular Vesicles: Natural Nanoparticles for Enhancing Oral Drug Delivery against Bacterial Infections

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(4), С. 1988 - 2000

Опубликована: Март 26, 2024

Oral drug delivery is typically preferred as a therapeutic intervention due to the complexities and expenses associated with intravenous administration. However, some drugs are poorly absorbed orally, requiring administration bypass gastrointestinal tract deliver directly into bloodstream. Thus, there an urgent need develop novel platforms overcome challenges of oral low solubility, permeability, degradation, bioavailability. Advances in extracellular vesicles (EVs) natural carriers have provided emerging approaches improve potential applications. Milk not only contains traditional nutrients but also rich EVs. In this Review, we focus mainly on purification milk EVs (mEVs), their safety, advantages mEV-based combatting intestinal infections. Additionally, summarize several mEVs over conventional synthetic carriers, such immunogenicity, high biocompatibility, ability transfer bioactive molecules between cells. Considering unmet gaps clinical translation, it essential review cargo loading future perspectives for use delivery. This overview sheds light alternative treat infections pathogens development systems.

Язык: Английский

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Enhanced antibacterial activity of bovine milk exosome-based drug formulation against bacterial pathogens

Food Chemistry, Год журнала: 2024, Номер 447, С. 139034 - 139034

Опубликована: Март 15, 2024

Язык: Английский

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Milk-derived small extracellular vesicles inhibit the MAPK signaling pathway through CD36 in chronic apical periodontitis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133422 - 133422

Опубликована: Июнь 24, 2024

Small extracellular vesicles derived from milk (Milk-sEVs) have the advantages of easy availability, low cost, toxicity, and inhibition inflammation. CD36 mediates inflammation stress in a variety disease states. The purpose this study was to investigate role Milk-sEVs inhibiting fibroblast through provide reference data for treatment chronic apical periodontitis.

Язык: Английский

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Oral Delivery of Photoresponsive Milk-Derived Exosomes for the Local Therapy of Glioblastoma

ACS Materials Letters, Год журнала: 2024, Номер 6(9), С. 4019 - 4027

Опубликована: Июль 31, 2024

Most orally administered drugs struggle to reach intracerebral regions due the intestinal epithelial barrier (IEB) and blood–brain (BBB). In this study, we investigate potential of milk-derived exosomes (mExos) as a noninvasive solution overcome both barriers, facilitating photodynamic therapy (PDT) glioblastoma. By leveraging inherent properties mExos, our goal is ensure optimal efficacy by delivering concentrated dose photosensitizer desired region. context, developed photoresponsive mExos loaded with chlorin e6 (Ce6@mExo) for glioblastoma treatment. Intriguingly, findings reveal that Ce6@mExo effectively traverses IEB BBB following oral administration, significantly accumulating in brain tissue. This enhanced accumulation correlates substantial tumor cell death orthotopic model upon laser irradiation. Our study underscores promise milk vehicles drug delivery via enhancing patient convenience therapeutic efficacy.

Язык: Английский

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Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 47137 - 47149

Опубликована: Авг. 6, 2024

With their low immunogenicity and excellent deliverability, extracellular vesicles (EVs) are promising platforms for drug delivery systems. In this study, hydrophobic molecule loading techniques were developed via an exchange reaction based on supramolecular chemistry without using organic solvents that can induce EV disruption harmful side effects. To demonstrate the availability of exchanging to prepare drug-loading EVs, boron cluster carborane (CB) was introduced EVs (CB@EVs), which is expected as a agent neutron capture therapy (BNCT). The enabled encapsulation CB disrupting structure forming aggregates. Single-particle analysis revealed uniformly introduce cargo molecules advantageous in formulating pharmaceuticals. performance CB@EVs agents BNCT demonstrated vitro vivo. Compared L-BPA, clinically available agent, delivered with liposomes, CB@EV systems exhibited highest activity due deliverability endocytosis-independent pathway. system deeply penetrate 3D cultured spheroids even presence matrices. EV-based could efficiently accumulate tumor tissues xenograft model mice high selectivity, mainly enhanced permeation retention effect, vivo therapeutic benefits compared L-BPA/fructose complex. All features also establishing anticancer platforms.

Язык: Английский

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Unlocking the Potential of Camel Milk-Derived Exosomes as Novel Delivery Systems: Enhanced Bioavailability of ARV-825 PROTAC for Cancer Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1070 - 1070

Опубликована: Авг. 15, 2024

This study investigates the use of camel milk-derived exosomes (CMEs) as carriers for ARV-825, an anticancer agent targeting bromodomain-containing protein 4 (BRD4), in oral chemotherapy. CMEs were isolated and characterized, ARV-825-loaded CME formulations prepared evaluated through various vitro vivo tests. The ARV-825-CME formulation exhibited entrapment efficiency 42.75 ± 5.05%, a particle size 136.8 1.94 nm, zeta potential -32.75 0.70 mV, ensuring stability sustained drug release. In studies showed 5.4-fold enhancement release kinetics compared to free ARV-825 solution. Permeability indicated 3.2-fold increase apparent permeability, suggesting improved cellular uptake. Cytotoxicity assays demonstrated potent activity, with IC50 values decreasing by 1.5 2-fold cancer cell lines SF8628 DIPG H1975R (resistant Osimertinib). pharmacokinetic Sprague-Dawley rats revealed superior systemic absorption bioavailability from CMEs, 2.55-fold plasma concentration 5.56-fold AUC. Distribution confirmed ileum. research highlights promising delivery platform enhancing its therapeutic efficacy offering novel approach treatment.

Язык: Английский

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Application of Milk Exosomes for Musculoskeletal Health: Talking Points in Recent Outcomes

Nutrients, Год журнала: 2023, Номер 15(21), С. 4645 - 4645

Опубликована: Ноя. 1, 2023

Milk is a nutrient-rich food source, and among the various milks, breast milk nutrient source provided by mothers to newborns in many mammals. Exosomes are nano-sized membranous extracellular vesicles that play important roles cell-to-cell communication. originate from endogenous synthesis dietary sources such as milk. Discovered through electron microscopy floating vesicles, existence of exosomes human was confirmed owing density between 1.10 1.18 g/mL sucrose gradient corresponding known detection MHC classes I II, CD63, CD81, CD86 on vesicles. To date, have been used for treating diseases, including cancers, widely proposed promising carriers delivery chemotherapeutic agents. However, few studies focus geriatric health, especially sarcopenia osteoporosis related bone muscle. Therefore, present study focused their cargoes, which potential candidates supplements, when combined with drugs, they can be effective musculoskeletal diseases. In this review, we introduce basic concepts, definition, sources, cargoes exosomes, exosome isolation characterization methods. Additionally, review recent literature system exosomes. Since inflammation oxidative stress underly disorders, reporting antioxidant anti-inflammatory properties also summarized. Finally, therapeutic targeting muscle health proposed.

Язык: Английский

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