POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT DOI Creative Commons
Emily L. Struttmann, Anish S. Shah,

Matthew Moreida

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, part flyover where patients are quietly withdrawing from workforce and largely disconnected advocacy resources growing more affluent regions[1]. To date, there no clinical test to diagnose PASC risk factors etiology remain unclear. Methods This prospective study investigates alongside pre-COVID-19 medical history, acute course, panel 25 blood biomarkers collected 100 New Orleans, LA, 52.5% Black cohort, providing unique opportunity describe symptoms associations within comorbidity-rich population. 107 participants recruited ClinSeqSer at University Medical Center (UMC) or Tulane (TMC) Orleans underwent symptom questionnaires 3-month intervals. samples their initial post-COVID follow-up visit were analyzed for cardiac, metabolic, inflammatory, coagulation, chemistry, hematologic markers laboratory. Results SPSS with positivity which was defined as presence three new-since-COVID present 12 weeks after COVID diagnosis. prevalence also demographics past history. Enrolled ranged 21-87 years old (median 53, mean 52.1, STD 13.7). 63% female, Black, 44% White, 3% Asian. 52% hospitalized during course. Severity participants’ prior known most subjects. For 82% subjects, nasal swab saliva SARS CoV-2 qRT-PCR value PCR values did not predict later PASC. Maximum severity scores assigned out 105 whom data collected. On average, reported over 5 75% who completed questionnaire time draw positive. Questionnaire results identified common including fatigue (64%), dyspnea (53%), myalgias (48%), trouble concentrating memory problems (50%). Over one third arthralgias (34%), headaches (40%), sleeping (40%). all reporting these symptoms, average frequency on scale 1 (mild) (severe) follows (frequency; severity): (3.3; 3.3), myalgia (3.4, 3.4), (3.1, 3.2). Comparison means analysis indicates that hemoglobin, hematocrit calcium lower positive but still normal range. Analysis females this 4.8 times likely be classified than males. Serology mild trend toward higher anti-N concentration, plasma proximity extension proteome detected IL-6 TNF, among vs non-PASC. Discussion highly prevalent subjects cohort. A commonly ordered labs unable distinguish non-PASC indicating an ongoing need diagnostic relevant across diverse patient groups.

Язык: Английский

COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14876 - 14876

Опубликована: Окт. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Язык: Английский

Процитировано

58
Post-COVID dysautonomias: what we know and (mainly) what we don’t know DOI
David S. Goldstein

Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 99 - 113

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

20
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort DOI
Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi

и другие.

Annals of Internal Medicine, Год журнала: 2024, Номер 177(9), С. 1209 - 1221

Опубликована: Авг. 12, 2024

There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).

Язык: Английский

Процитировано

14
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study DOI Creative Commons
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 10, 2024

Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.

Язык: Английский

Процитировано

7
Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients DOI Creative Commons
Alejandro J. Gonzalez-Ochoa, Győző Szolnoky,

Ana G Hernandez-Ibarra

и другие.

Clinical and Applied Thrombosis/Hemostasis, Год журнала: 2025, Номер 31

Опубликована: Янв. 1, 2025

Introduction Persistent elevation of biomarkers associated with endothelial dysfunction in convalescent COVID-19 patients has been linked to an increased risk long-term cardiovascular complications, including long COVID syndrome. Sulodexide, known for its vascular affinity, demonstrated pleiotropic protective properties. This study aims evaluate the impact sulodexide on serum levels during phase COVID-19. Methods We conducted a double-blind, single-center, randomized, placebo-controlled trial Mexico, comparing (250 LRU orally, twice daily) placebo over 8 weeks adult early convalescence. Differences between groups were analyzed using repeated measures and post hoc tests, Thrombomodulin (TM) as primary endpoint. Results Among 206 (103 each group), at week 8, group exhibited significantly lower mean (25.2 ± 7.9 ng/mL vs 29.9 14.7 ng/mL, P = .03), von Willebrand Factor (vWF) (232 131 U/dL 266 122 U/dL, .02) Interleukin-6 (IL-6) (12.5 13.2 pg/mL 16.2 16.5 pg/mL, .03) compared group. D-dimer C reactive protein (CRP) also lowered. No significant differences observed P-selectin, fibrinogen, VCAM-1, or ICAM-1 levels. Conclusions Patients who received eight showed reduction TM, vWF, D-dimer, CRP, IL-6 placebo. These findings suggest potential effect against thromboinflammation damage.

Язык: Английский

Процитировано

0
T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID DOI Creative Commons
Renaud Cezar, Lucy Kundura,

Sónia André

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 3, 2024

As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.

Язык: Английский

Процитировано

4
Autoimmunity and long COVID in children DOI Creative Commons
Oksana Boyarchuk, L.A. Volianska

Reumatologia/Rheumatology, Год журнала: 2024, Номер 61(6), С. 492 - 501

Опубликована: Янв. 18, 2024

Numerous hypotheses regarding the pathogenetic mechanisms of long COVID have been proposed. Immune dysregulation and autoimmunity are among leading hypotheses. In this article, we pre-sent two clinical cases COVID. The first case demonstrates phenotype with pain musculoskeletal symptoms, which is often associated mimics systemic connective tissue diseases. second case, a high titer antinuclear antibodies was observed after SARS-CoV-2 infection, but symptoms were limited to fever headache. Only comprehensive evaluation thorough objective examination can con-firm or exclude autoimmune diseases previous infection. A systematic search in PubMed Medline database carried out for studies focusing on immune dysregulation, auto-immunity, its association question role development management approaches discussed.

Язык: Английский

Процитировано

4
Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature DOI Creative Commons
Siqi Liu,

Mengli Zhong,

Hao Wu

и другие.

Microorganisms, Год журнала: 2024, Номер 12(2), С. 332 - 332

Опубликована: Фев. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Язык: Английский

Процитировано

4
Utility of Protein Markers in COVID-19 Patients DOI Open Access
Alicia López-Biedma, María Ángeles Onieva-García, Desirée Martín‐García

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 653 - 653

Опубликована: Янв. 14, 2025

COVID-19 has been a challenge at the healthcare level not only in early stages of pandemic, but also subsequent appearance long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers an attempt improve clinical care, guide treatment and predict possible patient outcomes. Proteins such as C-reactive protein (CRP) or interleukin 6 (IL-6) are clear markers severe disease, many others proposed that could help risk stratification prediction specific complications. This review aims bring together most relevant studies this regard, providing information notable relation found date.

Язык: Английский

Процитировано

0