CLINICAL AND EPIDEMIOLOGICAL FEATURES OF THE COURSE OF CORONAVIRUS INFECTION DEPENDING ON THE PERIOD OF ILLNESS DOI
Oleksandr Saienko, Mykola Dmytrovych Chemych

Інфекційні хвороби, Journal Year: 2024, Volume and Issue: 3, P. 28 - 34

Published: Oct. 11, 2024

After the COVID-19 pandemic, persistence of Long COVID symptoms is particular concern, which significantly affects quality life and ability to work. The aim study establish peculiarities clinical epidemiological data in patients infected with SARS-CoV-2 depending on period illness. Patients methods. We examined 108 divided into three groups: those confirmed COVID-19, COVID, practically healthy persons. features course were determined based analysis medical records developed questionnaire. Results. Women predominated among subjects (56 %) an average age 41.44 years. main that characterized picture generalized weakness/fatigue (94 %), headache (74 fever/body aches cough 71 % (p<0.05). In group, compared (40 (29 (3 (9 less common, sleep disorders / insomnia (17 muscle pain (11 shortness breath runny nose sneezing (6 loss (worsening) appetite sore throat difficulty concentrating abdominal Conclusions. Reduced access healthcare services leads delayed hospitalization, prolonged treatment, complications. level vaccination does not affect risk COVID. Clinical signs COVID: weakness/fatigue, anxiety, mood disturbance, are detected one third cause a decrease overall life. most persistent general headache, breath, disorders/insomnia persist 34-42 from moment confirmed.

Language: Английский

COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

Citations

68
Post-COVID dysautonomias: what we know and (mainly) what we don’t know DOI
David S. Goldstein

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 99 - 113

Published: Jan. 11, 2024

Language: Английский

Citations

21
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

Citations

4
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort DOI
Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi

et al.

Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: 177(9), P. 1209 - 1221

Published: Aug. 12, 2024

There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).

Language: Английский

Citations

16
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study DOI Creative Commons
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 10, 2024

Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.

Language: Английский

Citations

8
Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study DOI Creative Commons
Chithira V Nair,

Malavika Krishnakumar,

Georg Gutjahr

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 24, 2025

Post-acute sequelae of SARS-CoV-2 infection (PASC) represent a significant challenge in patient care, with symptoms persisting beyond three month's post-recovery. This study aimed to evaluate the incidence PASC at one year post-COVID-19 and identify predictive biomarkers comorbidities for effective risk stratification. A cohort 120 adult patients, including 50 intensive care 70 non-intensive was followed up two weeks, six one-year post-discharge using structured questionnaires. The integrated laboratory forecast PASC. median age participants 56 years, 40% having moderate severe comorbidities. post-recovery, 32.8% exhibited post COVID-19 conditions. most common were constitutional (16%), respiratory (8.4%), neuropsychiatric (2.5%). Bayesian network analysis indicated correlations between symptoms, rehospitalisation, C-reactive protein, lactate-dehydrogenase, ferritin, albumin. highlights prolonged impact PASC, infection. It role specific such as albumin tailoring individual by advancing understanding prediction. Our findings support need further research refine these insights, which are pivotal ongoing patients aftermath COVID-19.

Language: Английский

Citations

1
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations DOI Creative Commons
Elisa Gentilotti, Lorenzo Maria Canziani,

Maria Giulia Caponcello

et al.

Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID DOI Creative Commons
Renaud Cezar, Lucy Kundura,

Sónia André

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.

Language: Английский

Citations

5
Autoimmunity and long COVID in children DOI Creative Commons
Oksana Boyarchuk, L.A. Volianska

Reumatologia/Rheumatology, Journal Year: 2024, Volume and Issue: 61(6), P. 492 - 501

Published: Jan. 18, 2024

Numerous hypotheses regarding the pathogenetic mechanisms of long COVID have been proposed. Immune dysregulation and autoimmunity are among leading hypotheses. In this article, we pre-sent two clinical cases COVID. The first case demonstrates phenotype with pain musculoskeletal symptoms, which is often associated mimics systemic connective tissue diseases. second case, a high titer antinuclear antibodies was observed after SARS-CoV-2 infection, but symptoms were limited to fever headache. Only comprehensive evaluation thorough objective examination can con-firm or exclude autoimmune diseases previous infection. A systematic search in PubMed Medline database carried out for studies focusing on immune dysregulation, auto-immunity, its association question role development management approaches discussed.

Language: Английский

Citations

4
Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature DOI Creative Commons
Siqi Liu,

Mengli Zhong,

Hao Wu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 332 - 332

Published: Feb. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Language: Английский

Citations

4