Post-COVID syndrome in patients with type 2 diabetes: definition, epidemiology, pathophysiology, biomarkers and genetic associations DOI Creative Commons
S. A. Sukhanov, Yu. А. Sorokina, О. В. Занозина

et al.

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 6, P. 89 - 97

Published: April 24, 2024

The article presents the modern ideas about post-COVID syndrome, indicates various types and classifications of provides epidemiological data, including patients with type 2 diabetes, also definition syndrome is given. group defined as very heterogeneous. Post-COVID more common in elderly, comorbid pathology, severe disease. pathophysiology this diabetes mellitus analyzed, risk factors are indicated. main biomarkers disorders were determined: monocytes their coefficients, acute phase proteins, some biochemical indicators, analysis genetic associations severity (interferon gamma gene, methylenetetrahydrofolate reductase ACE2 inhibitor). Genotyping a sample 26 single nucleotide polymorphisms genes implicated viral entry, immune response, inflammation significantly associated not only long-term COVID-19 symptoms, but cumulative incidence syndrome. Elevated levels interleukin 6, C-reactive protein tumor necrosis factor alpha may serve potential diagnostic COVID blood vascular transformation have great for diagnosis, angiogenesis modulators therapeutic efficacy It has been shown that vast majority patients, particular those suffering from develop post-COVID-19 taking into account pre-existing diseases, so harmless. By identifying associations, it possible to identify molecular mechanism mellitus. novelty disease association studies context new insights management rapidly evolving syndromes significant global implications.

Language: Английский

COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

Citations

67
Post-COVID dysautonomias: what we know and (mainly) what we don’t know DOI
David S. Goldstein

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 99 - 113

Published: Jan. 11, 2024

Language: Английский

Citations

20
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort DOI
Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi

et al.

Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: 177(9), P. 1209 - 1221

Published: Aug. 12, 2024

There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).

Language: Английский

Citations

15
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study DOI Creative Commons
Joan Carles Domingo, Federica Battistini, Begoña Cordobilla

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 10, 2024

Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers illness severity these conditions.

Language: Английский

Citations

7
T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID DOI Creative Commons
Renaud Cezar, Lucy Kundura,

Sónia André

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

As about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology so-called long COVID.

Language: Английский

Citations

5
Autoimmunity and long COVID in children DOI Creative Commons
Oksana Boyarchuk, L.A. Volianska

Reumatologia/Rheumatology, Journal Year: 2024, Volume and Issue: 61(6), P. 492 - 501

Published: Jan. 18, 2024

Numerous hypotheses regarding the pathogenetic mechanisms of long COVID have been proposed. Immune dysregulation and autoimmunity are among leading hypotheses. In this article, we pre-sent two clinical cases COVID. The first case demonstrates phenotype with pain musculoskeletal symptoms, which is often associated mimics systemic connective tissue diseases. second case, a high titer antinuclear antibodies was observed after SARS-CoV-2 infection, but symptoms were limited to fever headache. Only comprehensive evaluation thorough objective examination can con-firm or exclude autoimmune diseases previous infection. A systematic search in PubMed Medline database carried out for studies focusing on immune dysregulation, auto-immunity, its association question role development management approaches discussed.

Language: Английский

Citations

4
Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature DOI Creative Commons
Siqi Liu,

Mengli Zhong,

Hao Wu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 332 - 332

Published: Feb. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Language: Английский

Citations

4
Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients DOI Creative Commons
Alejandro J. Gonzalez-Ochoa, Győző Szolnoky,

Ana G Hernandez-Ibarra

et al.

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Introduction Persistent elevation of biomarkers associated with endothelial dysfunction in convalescent COVID-19 patients has been linked to an increased risk long-term cardiovascular complications, including long COVID syndrome. Sulodexide, known for its vascular affinity, demonstrated pleiotropic protective properties. This study aims evaluate the impact sulodexide on serum levels during phase COVID-19. Methods We conducted a double-blind, single-center, randomized, placebo-controlled trial Mexico, comparing (250 LRU orally, twice daily) placebo over 8 weeks adult early convalescence. Differences between groups were analyzed using repeated measures and post hoc tests, Thrombomodulin (TM) as primary endpoint. Results Among 206 (103 each group), at week 8, group exhibited significantly lower mean (25.2 ± 7.9 ng/mL vs 29.9 14.7 ng/mL, P = .03), von Willebrand Factor (vWF) (232 131 U/dL 266 122 U/dL, .02) Interleukin-6 (IL-6) (12.5 13.2 pg/mL 16.2 16.5 pg/mL, .03) compared group. D-dimer C reactive protein (CRP) also lowered. No significant differences observed P-selectin, fibrinogen, VCAM-1, or ICAM-1 levels. Conclusions Patients who received eight showed reduction TM, vWF, D-dimer, CRP, IL-6 placebo. These findings suggest potential effect against thromboinflammation damage.

Language: Английский

Citations

0
Utility of Protein Markers in COVID-19 Patients DOI Open Access
Alicia López-Biedma, María Ángeles Onieva-García, Desirée Martín‐García

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 653 - 653

Published: Jan. 14, 2025

COVID-19 has been a challenge at the healthcare level not only in early stages of pandemic, but also subsequent appearance long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers an attempt improve clinical care, guide treatment and predict possible patient outcomes. Proteins such as C-reactive protein (CRP) or interleukin 6 (IL-6) are clear markers severe disease, many others proposed that could help risk stratification prediction specific complications. This review aims bring together most relevant studies this regard, providing information notable relation found date.

Language: Английский

Citations

0