POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT DOI Creative Commons
Emily L. Struttmann, Anish S. Shah,

Matthew Moreida

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, part flyover where patients are quietly withdrawing from workforce and largely disconnected advocacy resources growing more affluent regions[1]. To date, there no clinical test to diagnose PASC risk factors etiology remain unclear. Methods This prospective study investigates alongside pre-COVID-19 medical history, acute course, panel 25 blood biomarkers collected 100 New Orleans, LA, 52.5% Black cohort, providing unique opportunity describe symptoms associations within comorbidity-rich population. 107 participants recruited ClinSeqSer at University Medical Center (UMC) or Tulane (TMC) Orleans underwent symptom questionnaires 3-month intervals. samples their initial post-COVID follow-up visit were analyzed for cardiac, metabolic, inflammatory, coagulation, chemistry, hematologic markers laboratory. Results SPSS with positivity which was defined as presence three new-since-COVID present 12 weeks after COVID diagnosis. prevalence also demographics past history. Enrolled ranged 21-87 years old (median 53, mean 52.1, STD 13.7). 63% female, Black, 44% White, 3% Asian. 52% hospitalized during course. Severity participants’ prior known most subjects. For 82% subjects, nasal swab saliva SARS CoV-2 qRT-PCR value PCR values did not predict later PASC. Maximum severity scores assigned out 105 whom data collected. On average, reported over 5 75% who completed questionnaire time draw positive. Questionnaire results identified common including fatigue (64%), dyspnea (53%), myalgias (48%), trouble concentrating memory problems (50%). Over one third arthralgias (34%), headaches (40%), sleeping (40%). all reporting these symptoms, average frequency on scale 1 (mild) (severe) follows (frequency; severity): (3.3; 3.3), myalgia (3.4, 3.4), (3.1, 3.2). Comparison means analysis indicates that hemoglobin, hematocrit calcium lower positive but still normal range. Analysis females this 4.8 times likely be classified than males. Serology mild trend toward higher anti-N concentration, plasma proximity extension proteome detected IL-6 TNF, among vs non-PASC. Discussion highly prevalent subjects cohort. A commonly ordered labs unable distinguish non-PASC indicating an ongoing need diagnostic relevant across diverse patient groups.

Язык: Английский

Early biomarkers in hospitalized patients as predictors of post-acute sequelae of SARS-CoV-2 infection: a one-year cohort study DOI Creative Commons
Chithira V Nair,

Malavika Krishnakumar,

Georg Gutjahr

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Март 24, 2025

Post-acute sequelae of SARS-CoV-2 infection (PASC) represent a significant challenge in patient care, with symptoms persisting beyond three month's post-recovery. This study aimed to evaluate the incidence PASC at one year post-COVID-19 and identify predictive biomarkers comorbidities for effective risk stratification. A cohort 120 adult patients, including 50 intensive care 70 non-intensive was followed up two weeks, six one-year post-discharge using structured questionnaires. The integrated laboratory forecast PASC. median age participants 56 years, 40% having moderate severe comorbidities. post-recovery, 32.8% exhibited post COVID-19 conditions. most common were constitutional (16%), respiratory (8.4%), neuropsychiatric (2.5%). Bayesian network analysis indicated correlations between symptoms, rehospitalisation, C-reactive protein, lactate-dehydrogenase, ferritin, albumin. highlights prolonged impact PASC, infection. It role specific such as albumin tailoring individual by advancing understanding prediction. Our findings support need further research refine these insights, which are pivotal ongoing patients aftermath COVID-19.

Язык: Английский

Процитировано

0
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations DOI
Elisa Gentilotti, Lorenzo Maria Canziani,

Maria Giulia Caponcello

и другие.

Clinical Microbiology and Infection, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Children and Young People with Long COVID—Comparing Those Seen in Post-COVID Services with a Non-Hospitalised National Cohort: A Descriptive Study DOI Creative Commons
Fiona Newlands, Anne‐Lise Goddings,

Maude Juste

и другие.

Children, Год журнала: 2023, Номер 10(11), С. 1750 - 1750

Опубликована: Окт. 28, 2023

Post-COVID services have been set up in England to treat children with ongoing symptoms of Long COVID. To date, the characteristics seeking treatment from these has not described.

Язык: Английский

Процитировано

7
An update on Long COVID DOI Creative Commons

Gary Grohmann,

Robert Booy

Microbiology Australia, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

'Long COVID' is a major dilemma, difficult to diagnose and even more challenging treat. Millions are still being affected globally ~10% of people experience Long COVID following acute infection. Many complain about fatigue, brain fog mental difficulties, ~200 symptoms described making diagnosis difficult. Both COVID-19 can cause organ damage – involving the heart, lungs, kidneys, brain; as well inflammation, studies suggest that severe dominated by endothelial immunological dysfunction, immunothrombosis. Diagnostic tests for largely in development finding effective therapies has been challenge; however, it likely antivirals have role preventing treating COVID. Real-world data support effectiveness vaccines reducing risk remains challenge needs considerable on-going research determine treatments. The global public health emergency may be over but fallout will with us some time.

Язык: Английский

Процитировано

2
Navigating the Long Haul: A Comprehensive Review of Long-COVID Sequelae, Patient Impact, Pathogenesis, and Management DOI Open Access

Nishant Rathod,

Sunil Kumar,

Roma Chavhan

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Май 13, 2024

Long COVID, characterized by persistent symptoms following a SARS-CoV-2 infection, presents significant public health challenge with wide-ranging implications. This comprehensive review explores the epidemiology, clinical manifestations, pathogenesis, risk factors, diagnosis, patient impact, management strategies, and long-term prognosis of COVID. Despite varied symptomatology that spans multiple organ systems, including respiratory, neurological, cardiovascular this condition is primarily associated chronic inflammation potential viral persistence. Prevalence varies, influenced initial infection severity, demographic pre-existing conditions. The emphasizes necessity for healthcare systems to adapt needs long-COVID patients developing standardized diagnostic criteria personalized, multidisciplinary treatment approaches. Current research gaps future directions are identified, highlighting urgent need further studies on pathophysiological mechanisms effective therapeutic interventions. aims inform providers, researchers, policymakers, enhancing care guiding ongoing initiatives. continuing global focus collaborative efforts offer hope improved outcomes those affected long marking an essential step towards addressing emergent comprehensively.

Язык: Английский

Процитировано

2
Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence DOI Creative Commons
Juan José Oropeza-Valdez, Cristian Padrón-Manrique, Aarón Vázquez-Jiménez

и другие.

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Сен. 9, 2024

The COVID-19 pandemic, caused by SARS-CoV-2, has led to significant challenges worldwide, including diverse clinical outcomes and prolonged post-recovery symptoms known as Long COVID or Post-COVID-19 syndrome. Emerging evidence suggests a crucial role of metabolic reprogramming in the infection's long-term consequences. This study employs novel approach utilizing machine learning (ML) explainable artificial intelligence (XAI) analyze alterations patients. Samples were taken from cohort 142 COVID-19, 48 Post-COVID-19, 38 control patients, comprising 111 identified metabolites. Traditional analysis methods, like PCA PLS-DA, compared with ML techniques, particularly eXtreme Gradient Boosting (XGBoost) enhanced SHAP (SHapley Additive exPlanations) values for explainability. XGBoost, combined SHAP, outperformed traditional demonstrating superior predictive performance providing new insights into basis disease's progression aftermath. revealed metabolomic subgroups within conditions, suggesting heterogeneous responses infection its impacts. Key signatures include taurine, glutamine, alpha-Ketoglutaric acid, LysoPC C16:0. highlights potential integrating XAI fine-grained description metabolomics research, offering more detailed understanding anomalies conditions.

Язык: Английский

Процитировано

2
Unmasking Pandemic Echoes: An In-Depth Review of Long COVID’s Unabated Cardiovascular Consequences beyond 2020 DOI Creative Commons
Maria‐Luiza Luchian, Julien Higny, Martin Benoît

и другие.

Diagnostics, Год журнала: 2023, Номер 13(21), С. 3368 - 3368

Опубликована: Ноя. 2, 2023

At the beginning of 2020, coronavirus disease 2019 (COVID-19) emerged as a new pandemic, leading to worldwide health crisis and overwhelming healthcare systems due high numbers hospital admissions, insufficient resources, lack standardized therapeutic protocols. Multiple genetic variants severe acute respiratory syndrome 2 (SARS-CoV-2) have been detected since its first public declaration in some them being considered concern (VOCs) corresponding several pandemic waves. Nevertheless, growing number COVID-19 patients are continuously discharged from hospitals, remaining symptomatic even months after their episode infection. Long or ‘post-acute syndrome’ characterized by variability clinical manifestations ranging cardiorespiratory neurological symptoms such chest pain, exertional dyspnoea cognitive disturbance psychological disturbances, e.g., depression, anxiety sleep with crucial impact on patients’ quality life. Moreover, COVID is viewed cardiovascular risk factor capable modifying trajectory current future diseases, altering prognosis. Therefore, this review we address definitions pathophysiology, focus manifestations. Furthermore, aim mechanisms chronic cardiac injury variety sequelae observed recovered patients, addition potential role clinics medical management condition. We will further research for better understanding actual directions.

Язык: Английский

Процитировано

4
Traumatic Brain Injury in the Long-COVID Era DOI Creative Commons
Denes V. Agoston

Neurotrauma Reports, Год журнала: 2024, Номер 5(1), С. 81 - 94

Опубликована: Янв. 1, 2024

Major determinants of the biological background or reserve, such as age, sex, comorbidities (diabetes, hypertension, obesity, etc.), and medications (e.g., anticoagulants), are known to affect outcome after traumatic brain injury (TBI). With unparalleled data richness coronavirus disease 2019 (COVID-19; ∼375,000 counting!) well chronic form, long-COVID, also called post-acute sequelae SARS-CoV-2 infection (PASC), publications (∼30,000 counting) covering virtually every aspect diseases, pathomechanisms, biomarkers, phases, symptomatology, etc., have provided a unique opportunity better understand appreciate holistic nature interconnectivity between organ systems, importance in modifying trajectories affecting outcomes. Such approach is badly needed TBI-induced conditions their totality. Here, I briefly review what about long-COVID/PASC, its underlying—suspected—pathologies, pathobiological changes induced by TBI, other words, TBI endophenotypes, discuss intersection long-COVID/PASC pathobiologies, how considering some factors person's inclusion mechanistic molecular biomarkers can help improve clinical management patients.

Язык: Английский

Процитировано

1
Post-COVID and diabetes mellitus DOI
Lena Bandelin-Franke, Carmen Scheibenbogen,

Thomas Bobbert

и другие.

Deleted Journal, Год журнала: 2024, Номер 20(3), С. 356 - 363

Опубликована: Март 6, 2024

Im Rahmen der COVID-19-Pandemie (COVID-19: "coronavirus disease 2019") zeigten sich zahlreiche bidirektionale Einflüsse Infektionskrankheit auf nicht übertragbare Erkrankungen wie den Diabetes mellitus. Die Studienlage erweist teilweise als kontrovers, was am ehesten die uneinheitliche Erfassung SARS-CoV-2-Infektionen (SARS-CoV-2: "severe acute respiratory syndrome coronavirus 2") sowie Komorbiditäten, häufig mit einhergehen, zurückzuführen ist. Während COVID-19 zu vermehrten hyperglykämischen Entgleisungen häufigeren und ausgeprägteren Ketoazidosen steroidinduzierten Diabetesmanifestationen führte, ging eine schlecht eingestellte glykämische Stoffwechsellage einer erhöhten COVID-19-Morbidität -Mortalität einher. Schwere COVID-19-Verläufe wiederum erwiesen prädisponierend für das Auftreten eines "post COVID syndrome" (PACS). Pathophysiologisch stehen hierbei chronische subklinische Inflammation, Insulinresistenz, Hypoxie endotheliale Dysfunktion im Vordergrund. von PACS wurden prolongierte Hyperglykämie, erhöhte proinflammatorische Serummarker Erstmanifestationen Typ-1-Diabetes Kindesalter beobachtet. Umgekehrt jedoch konnte keine Prävalenz typischer PACS-Symptome bei Menschen festgestellt werden. Präventive Maßnahmen beinhalten Vermeiden SARS-CoV-2-Infektion schwerer Verläufe durch Impfungen Optimierung Blutzuckereinstellung.

Процитировано

1
Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study DOI Open Access
Vanessa Costa Alves Galúcio,

Daniel Carvalho de Menezes,

Elem Cristina Rodrigues Chaves

и другие.

Journal of Medical Virology, Год журнала: 2024, Номер 96(8)

Опубликована: Июль 31, 2024

Abstract The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied new symptoms that persist after resolution acute 2019 (COVID‐19). This observational cross‐sectional study investigated 332 patients with COVID in Brazilian Amazon region. aimed elucidate systemic interactions associated compiling findings related hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants were identified using rigorous criteria underwent thorough laboratory examinations. obtained data subsequently analyzed, allowing for comparisons, associations, correlations between within distinct groups study. Significant associations observed hospitalization during phase persistent abnormalities, suggesting a potential link severity long‐term effects. Notably, individuals over year exhibited elevated levels monocytes, prolonged prothrombin times, reduced activity, high lactate dehydrogenase, an increased frequency qualitative C‐reactive protein detection. provides valuable insights into risk profile COVID, particularly unique context region, where exhibit lasting up 1261 days.

Язык: Английский

Процитировано

1