European Journal of Pharmaceutics and Biopharmaceutics,
Год журнала:
2024,
Номер
197, С. 114211 - 114211
Опубликована: Фев. 8, 2024
The
concentration
of
air
pollution
is
gradually
increasing
every
year
so
that
daily
skin
exposure
unavoidable.
Dietary
supplements
and
topical
formulations
currently
represent
the
protective
strategies
to
guard
against
effects
on
body
skin.
Unfortunately,
there
are
not
yet
enough
methods
available
measure
effectiveness
anti-pollution
products
Here,
we
present
two
ex
vivo
for
measuring
effect
different
cream
skin:
Electron
paramagnetic
resonance
(EPR)
spectroscopy
autofluorescence
excited
by
785
nm
using
a
confocal
Raman
microspectrometer
(CRM).
Smoke
from
one
cigarette
was
used
as
model
pollutant.
EPR
enables
direct
measurement
free
radicals
in
excised
porcine
after
smoke
exposure.
measured
vivo,
which
an
indicator
oxidative
stress.
Two
antioxidants
chelating
agent
base
formulation
commercial
product
containing
antioxidant
mixture
were
investigated.
studies
show
epigallocatechin-3-gallate
(EGCG)
provided
best
protection
stress
both
methods.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Год журнала:
2024,
Номер
99(5), С. 1772 - 1790
Опубликована: Апрель 30, 2024
Melatonin,
a
product
of
tryptophan
metabolism
via
serotonin,
is
molecule
with
an
indole
backbone
that
widely
produced
by
bacteria,
unicellular
eukaryotic
organisms,
plants,
fungi
and
all
animal
taxa.
Aside
from
its
role
in
the
regulation
circadian
rhythms,
it
has
diverse
biological
actions
including
cytoprotective
responses
other
functions
crucial
for
survival
across
different
species.
The
latter
properties
are
also
shared
metabolites
kynuric
products
generated
reactive
oxygen
species
or
phototransfomation
induced
ultraviolet
radiation.
Vitamins
D
related
photoproducts
originate
phototransformation
∆5,7
sterols,
which
7-dehydrocholesterol
ergosterol
examples.
Their
bonds
B
ring
absorb
solar
radiation
[290-315
nm,
(UVB)
radiation]
resulting
opening
to
produce
previtamin
D,
referred
as
secosteroid.
Once
formed,
can
either
undergo
thermal-induced
isomerization
vitamin
UVB
be
transformed
into
lumisterol
tachysterol.
Vitamin
well
tachysterol,
hydroxylated
cyochrome
P450
(CYP)
enzymes
biologically
active
hydroxyderivatives.
best
known
these
1,25-dihydroxyvitamin
(1,25(OH)
Cancers,
Год журнала:
2024,
Номер
16(12), С. 2262 - 2262
Опубликована: Июнь 18, 2024
Melanoma,
originating
through
malignant
transformation
of
melanin-producing
melanocytes,
is
a
formidable
malignancy,
characterized
by
local
invasiveness,
recurrence,
early
metastasis,
resistance
to
therapy,
and
high
mortality
rate.
This
review
discusses
etiologic
risk
factors
for
melanoma,
diagnostic
prognostic
tools,
including
recent
advances
in
molecular
biology,
omics,
bioinformatics,
provides
an
overview
its
therapy.
Since
the
incidence
melanoma
rising
remains
unacceptably
high,
we
discuss
inherent
properties,
melanogenesis,
that
make
this
disease
resilient
treatment
propose
use
AI
solve
above
complex
multidimensional
problems.
We
provide
on
vitamin
D
anticancerogenic
report
field
can
solutions
prevention
and/or
therapy
melanoma.
Experimental
papers
clinicopathological
studies
role
status
signaling
pathways
initiated
active
metabolites
prognosis
are
reviewed.
conclude
signaling,
defined
specific
nuclear
receptors
selective
activation
hydroxyderivatives,
benefit
new
or
existing
therapeutic
approaches.
target
with
computational
biology
tools
solution
problem.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
278, С. 116429 - 116429
Опубликована: Май 7, 2024
Air
pollutants
deteriorate
the
survival
environment
and
endanger
human
health
around
world.
A
large
number
of
studies
have
confirmed
that
air
pollution
jeopardizes
multiple
organs,
such
as
cardiovascular,
respiratory,
central
nervous
systems.
Skin
is
largest
organ
first
barrier
protects
us
from
outside
particulate
matter
(PM),
polycyclic
aromatic
hydrocarbons
(PAHs),
volatile
organic
compounds
(VOCs)
will
affect
structure
function
skin
bring
about
development
inflammatory
diseases
(atopic
dermatitis
(AD),
psoriasis),
accessory
(acne,
alopecia),
auto-immune
(cutaneous
lupus
erythematosus(CLE)
scleroderma),
even
tumors
(melanoma,
basal
cell
carcinoma
(BCC),
squamous-cell
(SCC)).
Oxidative
stress,
damage,
microbiome
dysbiosis,
inflammation
are
pathogenesis
stimulation.
In
this
review,
we
summarize
current
evidence
on
effects
possible
mechanisms
to
provide
strategies
for
future
research.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4101 - 4101
Опубликована: Апрель 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
Antioxidants,
Год журнала:
2024,
Номер
13(1), С. 91 - 91
Опубликована: Янв. 11, 2024
Diesel
particulate
matter
is
one
of
the
most
dangerous
environmental
stressors
affecting
human
health.
Many
plant-derived
compounds
with
antioxidant
and
anti-inflammatory
properties
have
been
proposed
to
protect
skin
from
pollution
damage.
Curcumin
(CUR)
has
a
plethora
pharmacological
activities,
including
anticancer,
antimicrobial,
antioxidant.
However,
it
low
bioavailability
due
its
difficult
absorption
rapid
metabolism
elimination.
CUR
encapsulation
in
nanotechnological
systems
combination
biopotentiators
such
as
piperine
(PIP)
can
improve
pharmacokinetics,
stability
activity.
In
this
study,
ethosomes
(ETs)
were
investigated
for
PIP
delivery
damage
induced
by
diesel
matter.
ETs
produced
different
strategies
characterized
their
size
distribution
photon
correlation
spectroscopy,
morphology
transmission
electron
microscopy,
drug
efficiency
high-performance
liquid
chromatography.
Franz
cells
enabled
us
evaluate
vitro
diffusion
ETs.
The
results
highlighted
that
promote
permeation
curcumin.
studies
carried
out
on
activity
demonstrated
an
increase
power
using
separately
loaded
ETs,
suggesting
possible
application
prevention
exogenous
stressors.
Ex
vivo
explants
shown
suitability
drug-loaded
prevent
structural
engine
exhaust
exposure.
Biochemical Pharmacology,
Год журнала:
2024,
Номер
223, С. 116156 - 116156
Опубликована: Март 20, 2024
The
skin,
lung,
and
gut
are
important
barrier
organs
that
control
how
the
body
reacts
to
environmental
stressors
such
as
ultraviolet
(UV)
radiation,
air
pollutants,
dietary
components,
microorganisms.
aryl
hydrocarbon
receptor
(AhR)
is
a
ligand-dependent
transcription
factor
plays
an
role
in
maintaining
homeostasis
of
organs.
AhR
was
initially
discovered
for
chemical
carcinogens
polycyclic
aromatic
hydrocarbons
(PAHs).
Activation
pathways
by
PAHs
leads
increased
DNA
damage
mutations
which
ultimately
lead
carcinogenesis.
Ongoing
evidence
reveals
ever-expanding
AhR.
Recently,
has
been
linked
immune
systems
interaction
with
development
natural
killer
(NK)
cells,
regulatory
T
(T
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disease
characterized
by
compromised
epidermal
barrier
and
heightened
immunoglobulin
E
(IgE)
levels,
often
associated
with
filaggrin
(FLG)
gene
mutations.
Genetic
factors
like
FLG
mutations
environmental
influences,
including
microbial
exposure
pollutants,
contribute
to
the
disease’s
progression,
leading
itchy,
inflamed
skin.
AD
frequently
coexists
allergic
conditions,
severely
affecting
quality
of
life.
The
pathogenesis
involves
complex
interactions
between
genetic
predispositions,
immune
responses,
triggers.
Despite
advances,
development
effective
treatments
remains
challenging
due
an
incomplete
understanding
how
influence
pathways
variability
in
presentation.
Current
biomarkers
are
insufficient
fully
capture
complexity
or
predict
therapeutic
highlighting
need
for
novel
personalized
approaches.
Emerging
therapies
such
as
chimeric
antigen
receptor
(CAR)-T
cell
therapy,
stem
regenerative
medicine
show
promise
addressing
AD’s
root
causes.
This
review
explores
key
aspects
pathogenesis,
focusing
on
dysfunction,
mechanisms,
innovative
strategies
improve
patient
outcomes.
