Clinical Reviews in Allergy & Immunology,
Год журнала:
2025,
Номер
68(1)
Опубликована: Фев. 11, 2025
Sjögren's
syndrome
(SS)
is
a
chronic
autoimmune
disorder
that
primarily
affects
the
exocrine
glands.
Due
to
intricate
nature
of
disease
progression,
exact
mechanisms
underlying
SS
are
not
completely
understood.
Recent
research
has
highlighted
complex
interplay
between
immune
dysregulation
and
metabolic
abnormalities
in
inflammatory
diseases.
Notably,
lipid
metabolism
emerged
as
crucial
factor
modulation
function
progression
diseases,
including
SS.
This
review
explores
prevalence
dyslipidemia
SS,
emphasizing
its
role
onset,
prognosis
disease.
We
specifically
described
impact
altered
glands
association
with
disease-specific
features,
inflammation
glandular
dysfunction.
Additionally,
we
discussed
potential
clinical
implications
regulation,
polyunsaturated
fatty
acids
(PUFAs)
their
deficits
pathogenesis.
By
identifying
promising
therapeutic
target,
this
highlights
need
for
further
into
lipid-based
interventions
management
Experimental Eye Research,
Год журнала:
2023,
Номер
237, С. 109716 - 109716
Опубликована: Ноя. 10, 2023
Sjogren's
syndrome
(SS)
is
a
chronic
autoimmune
disorder
that
affects
exocrine
glands,
particularly
lacrimal
leading
to
dry
eye
disease
(DED).
DED
common
ocular
surface
millions
of
people
worldwide,
causing
discomfort,
visual
impairment,
and
even
blindness
in
severe
cases.
However,
there
no
definitive
cure
for
DED,
existing
treatments
primarily
relieve
symptoms.
Consequently,
an
urgent
need
innovative
therapeutic
strategies
based
on
the
pathophysiology
DED.
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
promising
tool
various
disorders,
including
SS-related
(SS-DED).
A
intriguing
facet
MSCs
their
ability
produce
extracellular
vesicles
(EVs),
which
contain
bioactive
components
such
proteins,
lipids,
nucleic
acids.
These
molecules
play
key
role
facilitating
communication
between
modulating
wide
range
biological
processes.
Importantly,
MSC-derived
EVs
(MSC-EVs)
properties
similar
those
parent
cells,
immunomodulatory,
anti-inflammatory,
regenerative
properties.
In
addition,
MSC-EVs
offer
several
notable
advantages
over
intact
MSCs,
lower
immunogenicity,
reduced
risk
tumorigenicity,
greater
convenience
terms
storage
transport.
this
review,
we
elucidate
underlying
mechanisms
SS-DED
discuss
relevant
targets
treating
SS-DED.
comprehensively
review
broader
landscape
EV
application
corneal
diseases.
This
focuses
efficacy
SS-DED,
field
study
holds
considerable
appeal
due
its
multifaceted
regulation
immune
responses
functions.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1540 - 1540
Опубликована: Июль 11, 2024
Sjögren’s
syndrome
is
a
multisystemic
autoimmune
disease
that
mainly
affects
the
exocrine
glands,
causing
dryness
of
eyes
and
mouth
as
principal
symptoms.
Non-coding
RNAs
(ncRNAs),
once
regarded
genomic
“junk”,
are
now
appreciated
important
molecular
regulators
gene
expression,
not
least
in
other
diseases.
Here
we
review
research
into
causative
roles
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs)
on
immunological
responses,
inflammation,
salivary
gland
epithelial
cell
function
patients.
These
ncRNAs
represent
promising
new
therapeutic
targets
for
treating
possibly
biomarkers
early
diagnosis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13918 - 13918
Опубликована: Сен. 10, 2023
To
assess
the
relationship
between
endothelial
dysfunction
and
serum
cytokines,
anti-SSA
anti-SSB
antibodies,
beta-2
microglobulin
levels,
focus
score
EULAR
Sjögren’s
Syndrome
Disease
Activity
Index
(ESSDAI)
in
primary
syndrome
(pSS)
patients.
The
study
included
90
patients
with
pSS
45
healthy
subjects,
matched
for
age
gender,
as
controls.
Serum
microglobulin,
total
cholesterol,
HDL-cholesterol,
triglycerides,
TNF-α,
IL-6
were
analyzed
both
groups.
Patients
also
tested
antinuclear
anti-SAA
(anti-Sjögren’s
syndrome-related
antigen
A)
(anti-Sjögren
related
B)
(the
histopathologic
one,
based
on
minor
salivary
gland
biopsy).
Endothelial
was
assessed
by
means
of
flow-mediated
dilation
(FMD)
brachial
artery.
Data
are
presented
mean
±
standard
deviation.
Statistical
analysis
performed
using
t-test
Pearson’s
correlation.
Differences
considered
to
be
statistically
significant
if
value
p
<
0.05.
identified
(p
0.00001).
levels
cytokines
(TNF-α,
respective
IL-6)
increased
compared
controls
(expressed
FMD%)
correlated
score,
ESSDAI,
IL-6,
statistical
significance.
is
present
associated
a
high
activity
well
concentrations
pro-inflammatory
beta
2-microglobulin.
