Pharmaceuticals,
Год журнала:
2024,
Номер
17(5), С. 619 - 619
Опубликована: Май 10, 2024
The
inhalation
of
gasoline
vapors
(GV)
is
associated
with
developing
various
pathologies.
Particularly,
oil
refinery
and
gas
station
workers
are
at
a
greater
risk
lung
cancer,
kidney
bladder
hematological
disorders,
including
acute
myeloid
leukemia.
Therefore,
preventing
the
harmful
effects
GV
alleviating
their
consequences
appear
to
be
important
timely
issues.
In
this
study,
we
investigated
potential
vitamin
D3,
turmeric
powder,
combination
ameliorate
toxicity
fumes
in
rats.
Separate
groups
animals
fed
standard
rodent
diet,
or
without
supplementation
D3
(750
IU/kg
body
weight)
and/or
powder
(0.5%,
w/w,
food),
were
untreated
treated
(11.5
±
1.3
cm3/h/m3/day)
for
30,
60,
90
days.
Changes
weight
monitored
weekly.
Histological,
biochemical,
parameters
determined
end
each
treatment
period.
While
exposure
rats
resulted
time-dependent
reduction
weight,
but
not
root
combination,
partially
prevented
loss.
Macroscopical
histological
analyses
showed
pronounced
changes
organs
tissues
GV-treated
These
included
alveolar
wall
collapse
lungs,
destruction
lobular
structure
hepatocytolysis
liver,
shrinkage
fragmentation
glomeruli
kidneys,
disorganization
lymphoid
follicles
spleen.
However,
co-treatment
nutritional
supplements
tested,
especially
noticeably
alleviated
above
conditions.
This
was
accompanied
by
significant
improvement
blood
chemistry
parameters.
Collectively,
our
results
demonstrate
that
environmental
can
reduced
upon
D3.
fact
protective
activity
alone
higher
than
combined
suggests
combinations
these
may
always
more
beneficial
agent
applied
separately.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2125 - 2125
Опубликована: Фев. 9, 2024
Unlike
other
vitamins,
vitamin
D3
is
synthesised
in
skin
cells
the
body.
Vitamin
has
been
known
as
a
bone-related
hormone.
Recently,
however,
it
considered
an
immune
vitamin.
deficiency
influences
onset
of
variety
diseases.
regulates
production
proinflammatory
cytokines
such
tumour
necrosis
factor-α
(TNF-α)
through
binding
to
D
receptors
(VDRs)
cells.
Since
blood
levels
(25-OH-D3)
were
low
coronavirus
disease
2019
(COVID-19)
patients,
there
growing
interest
importance
maintaining
healthy
condition.
On
hand,
phytochemicals
are
compounds
derived
from
plants
with
over
7000
varieties
and
have
various
biological
activities.
They
mainly
health-promoting
effects
classified
terpenoids,
carotenoids,
flavonoids,
etc.
Flavonoids
anti-inflammatory
that
control
TNF-α
production.
Chronic
inflammation
induced
by
continuous
fundamental
cause
diseases
like
obesity,
dyslipidaemia,
diabetes,
heart
brain
diseases,
autoimmune
Alzheimer's
disease,
cancer.
In
addition,
ageing
process
chronic
inflammation.
This
review
explains
cooperative
suppression
inflammatory
responses,
how
balances
natural
response,
its
link
anti-ageing
effects.
synergistically
contribute
working
ageing-related
genes.
Furthermore,
prevention
processes
requires
maintenance
gut
microbiota,
which
related
daily
dietary
habits.
this
regard,
supplementation
plays
important
role.
association
non-disease
condition
called
"ME-BYO"
attractive
regimen,
effect
discussed
here
for
long
life.
Endocrine Metabolic & Immune Disorders - Drug Targets,
Год журнала:
2024,
Номер
24(15), С. 1794 - 1812
Опубликована: Фев. 12, 2024
The
Mediterranean
diet,
listed
as
the
intangible
cultural
heritage
of
humanity
by
UNESCO,
is
known
healthy
and
consumed
worldwide.
Japanese
diet
also
considered
healthy.
This
narrative
review
compares
with
its
counterpart.
Research
has
reported
that
people
in
regions,
such
Italy
Greece,
have
one-third
mortality
ratio
from
cardiovascular
diseases
compared
to
United
States
Northern
Europe
because
difference
eating
habits.
Therefore,
diets
are
A
typical
Western
containing
high
amounts
fat,
sugar,
calories
responsible
for
several
like
metabolic
syndrome
obesity,
which
induced
chronic
inflammation.
In
contrast,
contain
them
only
less.
similarity
between
substantial
intake
vegetables,
beans,
fish.
On
other
hand,
consumes
large
olive
oil,
especially
polyphenol-rich
extra
virgin
oil
dairy
products,
but
meat
consumption
relatively
small.
does
not
use
contains
abundant
fermented
foods,
seaweed.
Japan
longevity,
think
a
well-balanced
daily
good
preventing
curing
illness.
this
regard,
finding
non-disease
conditions,
so-called
"ME-BYO,"
before
manifestation
becoming
more
common.
review,
we
discuss
habit,
"The
Mediterranean-styled
diet,"
prevents
ME-BYO
condition
reduces
risk
various
diseases.
hybrid
diets,
suppressing
nutritional
intervention
beneficial
longevity.
Hence,
might
be
helpful
longevity
around
world.
Molecules,
Год журнала:
2023,
Номер
28(21), С. 7436 - 7436
Опубликована: Ноя. 5, 2023
Genistein
is
a
natural
compound
belonging
to
flavonoids,
having
antioxidant,
anti-inflammatory,
and
anti-neoplastic
properties.
considered
phytoestrogen.
As
such,
genistein
can
bind
estrogen
receptors
(ERα
ERβ),
although
with
lower
affinity
than
that
of
estradiol.
Despite
considerable
work,
the
effects
are
not
well
established
yet.
This
review
aims
clarify
role
on
female
male
reproductive
functions
in
mammals.
In
females,
at
high
dose,
diminishes
ovarian
activity
regulating
several
pathway
molecules,
such
as
topoisomerase
isoform
I
II,
protein
tyrosine
kinases
(v-src,
Mek-4,
ABL,
PKC,
Syk,
EGFR,
FGFR),
ABC,
CFTR,
Glut1,
Glut4,
5α-reductase,
PPAR-γ,
mitogen-activated
kinase
A,
histidine
kinase,
recently
circulating
RNA-miRNA.
The
effect
pregnancy
still
controversial.
males,
exerts
an
estrogenic
by
inducing
testosterone
biosynthesis.
interaction
both
synthetic
endocrine
disruptors
has
negative
testis
function.
positive
sperm
quality
debate.
conclusion,
potentially
beneficial
mechanisms
reproduction
females
males.
However,
this
dependent
species,
route,
time
administration.
Abstract
Mentha
haplocalyx
Briq.
(
M.
),
a
notable
member
of
the
Lamiaceae
family,
occupies
significant
role
in
realm
health
foods
and
botanical
medicines.
Traditionally,
it
has
been
employed
to
address
various
diseases,
including
colds,
coughs,
fever,
indigestion,
asthma,
influenza.
Recent
phytochemical
investigations
have
identified
presence
terpenoids,
flavonoids,
phenolic
acids,
anthraquinones,
alkanes,
polysaccharides
,
with
terpenoids
being
primary
bioactive
constituents.
Notably,
both
vitro
vivo
studies
demonstrated
its
diverse
benefits,
such
as
neuroprotective,
anti-asthmatic,
anti-inflammatory,
gut
improvement,
hypoglycemic,
anti-aging,
anti-bacterial,
antioxidant
effects.
Additionally,
is
rich
source
carbohydrates,
dietary
fiber,
amino
minerals,
vitamins,
further
underscoring
nutritional
value.
A
thorough
literature
review
was
conducted
using
databases
like
PubMed,
Google
Scholar,
Web
Science,
China
National
Knowledge
Infrastructure
(CNKI)
consolidate
existing
knowledge
on
.
This
synthesizes
recent
advancements
botany,
traditional
uses,
value,
phytochemistry,
research
edible
uses
Furthermore,
commercial
potential
future
opportunities
for
are
briefly
explored,
goal
fostering
continued
interest
this
multifunctional
plant
inspiring
endeavors.
Graphical
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 7, 2024
Background
As
the
novel
coronavirus
disease
2019
(COVID-19)
pandemic
subsides,
clinical
sequelae
are
becoming
more
problematic.
Interestingly,
statistical
data
indicate
that
Africa
has
experienced
lowest
number
of
cases
and
deaths,
with
an
unexpected
phenomenon
where
deaths
from
COVID-19
not
increased
significantly.
Several
studies
have
investigated
relationship
between
diet
coronavirus.
However,
no
systematic
review/meta-analysis
conclusively
linked
(phytochemicals
vitamin
D)
gut
microbiota
in
context
COVID-19.
Methods
This
study
examined
responses
to
Japan
Africa,
formulating
following
hypotheses:
(1)
a
healthy
is
effective
against
COVID-19,
(2)
blood
D
levels
associated
mortality,
(3)
microbiota.
To
investigate
these
hypotheses,
keyword
search
meta-analysis
were
conducted
using
PubMed,
each
hypothesis
was
tested.
Results
found
diet,
particularly
rich
phytochemicals
such
as
polyphenols
flavonoids,
An
association
detected
mortality.
The
its
amelioration.
These
findings
may
significant
implications
for
only
understanding
but
also
future
prevention
pneumonia.
Inhalation
of
gasoline
vapors
(GV)
is
associated
with
developing
various
pathologies.
Particularly,
oil
refinery
and
gas
station
workers
are
at
greater
risk
lung
cancer,
kidney
bladder
hematological
disorders,
including
acute
myeloid
leukemia.
Therefore,
preventing
the
harmful
effects
GV
alleviating
their
consequences
appear
to
be
an
important
timely
issue.
In
this
study,
we
investigated
potential
vitamin
D3,
turmeric
powder
combination
ameliorate
toxicity
fumes
in
rats.
Separate
groups
animals
fed
a
standard
rodent
diet,
or
without
supplementation
D3
(750
IU/kg
body
weight)
and/or
(0.5%,
w/w,
food),
were
untreated
treated
(11.5±1.3
cm3/h/m3/day)
for
30,
60
90
days.
Changes
weight
monitored
weekly.
Histological,
biochemical,
parameters
determined
end
each
treatment
period.
While
exposure
rats
resulted
time-dependent
reduction
weight,
but
not
root
combination,
partially
prevented
loss.
Macroscopical
histological
analyses
showed
pronounced
changes
organs
tissues
GV-treated
These
included
alveolar
wall
collapse
lungs,
destruction
lobular
structure
hepato-cytolysis
liver,
shrinkage
fragmentation
glomeruli
kidneys,
disorganization
lymphoid
follicles
spleen.
However,
co-treatment
nutritional
supplements
tested,
especially
noticeably
alleviated
above
conditions.
This
was
accompanied
by
significant
improvement
blood
chemistry
parameters.
Collectively,
our
results
demonstrate
that
environmental
can
reduced
upon
D3.
The
fact
protective
activity
alone
higher
than
combined
suggests
combinations
these
may
always
more
beneficial
agent
applied
separately.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 3, 2024
Predictive
genomics
can
support
treatment
decisions
by
giving
people
the
chance
to
act
in
time
prevent
serious
illness.
Tests
based
on
single
nucleotide
polymorphism
(SNP)
be
analyzed
various
methods.
Matrix-assisted
laser
desorption/ionization
time-of-flight
(MALDI-TOF)
mass
spectrometry
technology
detects
genetic
variants
their
individual
mass.
Standardized
workflow,
automation,
sensitivity,
quick
turnaround
time,
and
reliability
are
main
advantages
of
MALDI-TOF
use
molecular
analysis.
Beside
pharmacogenetics,
SNP
variation
plays
a
role
fields
medicine.
In
present
article
importance
SNPs
for
nutrigenetics
is
presented.
Especially,
aspects
fat
metabolism,
vitamin
intolerances
were
discussed.
