In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice

Environmental Health Perspectives, Год журнала: 2024, Номер 132(4)

Опубликована: Апрель 1, 2024

Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much these end up in oceans or landfills leading to a substantial accumulation environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled ingested by both animals and humans. A growing body evidence indicates MPs cross gut barrier enter lymphatic systemic circulation tissues such as lungs, liver, kidney, brain. The impacts mixed exposure on tissue function through metabolism remains largely unexplored.

Язык: Английский

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Microplastics contamination in food products: Occurrence, analytical techniques and potential impacts on human health

Current Research in Biotechnology, Год журнала: 2024, Номер 7, С. 100190 - 100190

Опубликована: Янв. 1, 2024

Chemically, microplastics (MPs) are synthetic materials composed of plastic monomers and additives vary in size from 0.1 to 5000 μm. Due their chemical stability the widespread use plastics for various purposes, MP contamination environment has increased dramatically, leading daily consumer products as well. Although previous studies have reported environmental impacts MPs, only a few highlighted occurrence MPs food possible effects on human health. Recent investigations identified particles drinking water other beverages, seafood, plant products, salt, sugar, honey, raising an alarm over safety quality these items. Ingestion, inhalation, dermal contact such goods common routes through which may enter body can several deleterious health including oxidative stress, inflammation, immunotoxicity, risk neoplasia, cellular metabolism impairment, neurotoxicity, gut microbiome dysbiosis, disruption reproductive system among others. A collective approach employing source control, recycling, biodegradable plastics, strengthening legislation, bioremediation could be promising sustainable solution control pollution. The key challenge appears standarize detection methods along with reducing well environment. Therefore, this review focuses current analysis, potential impacts, strategies mitigate It also adds novel findings, knowledge gaps, recommendations that guide future research field.

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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Microplastics in Food Products: Prevalence, Artificial Intelligence Based Detection, and Potential Health Impacts on Humans

Emerging contaminants, Год журнала: 2025, Номер unknown, С. 100477 - 100477

Опубликована: Янв. 1, 2025

Язык: Английский

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Placental and fetal enrichment of microplastics from disposable paper cups: implications for metabolic and reproductive health during pregnancy

Journal of Hazardous Materials, Год журнала: 2024, Номер 478, С. 135527 - 135527

Опубликована: Авг. 14, 2024

Язык: Английский

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Bridging the Gaps between Microplastics and Human Health

Microplastics, Год журнала: 2024, Номер 3(1), С. 46 - 66

Опубликована: Янв. 11, 2024

Given the broad and intense use of plastic, society is being increasingly affected by its degradation by-products, particularly microplastics (MPs), fragments smaller than 5 mm in size, nanoplastics (NPs), with sizes less 1 µm. MPs NPs may enter body primarily through inhalation, consumption, skin contact. Once ingested, can penetrate tissues, deviating to other parts potentially affecting important cellular pathways such as nonconforming chemokine receptors that control communication between fetus mother. Consequently, potential health harm induced via MP internalization a major issue, evidenced multiple studies demonstrating harmful consequences diverse animal models human cells. Here, an overview various modes exposure presented, including placental transfer, ingestion, breastmilk absorption, well fetal toxicity due plastic particles based on vitro studies. Though our environment are becoming more recognized, their developmental still scarcely known. Besides negatively pregnancy, have been shown developing fetus, given ability cross barrier. Still, considerable gaps remain understanding dispersion these precise types bearing greatest dangers. As result, we advocate for larger-scale epidemiological investigations, development novel approaches measuring NP exposures, necessity kinds guide future research efforts.

Язык: Английский

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Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3109 - 3121

Опубликована: Июль 20, 2024

Язык: Английский

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Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(5), С. 4186 - 4202

Опубликована: Апрель 30, 2024

As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.

Язык: Английский

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Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review

Polymers, Год журнала: 2024, Номер 16(19), С. 2807 - 2807

Опубликована: Окт. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Язык: Английский

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ROS-dependent degeneration of human neurons induced by environmentally relevant levels of micro- and nanoplastics of diverse shapes and forms

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 134017 - 134017

Опубликована: Март 13, 2024

Our study explores the pressing issue of micro- and nanoplastics (MNPs) inhalation their subsequent penetration into brain, highlighting a significant environmental health concern. We demonstrate that MNPs can indeed penetrate murine warranting further investigation neurotoxic effects in humans. then proceed to test impact at environmentally relevant concentrations, with focusing on variations size shape. findings reveal these induce oxidative stress, cytotoxicity, neurodegeneration human neurons, cortical neurons being more susceptible than nociceptors. Furthermore, we examine role biofilms MNPs, demonstrating serve as vehicle for pathogenic significantly exacerbate effects. This sequence investigations reveals minimal accumulation cause stress risking brain highlights need understand neurological consequences inhaling MNPs. Overall, our developed vitro testing battery has significance elucidating factors associated pathological mechanisms neurons.

Язык: Английский

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