Salivary biomarkers as pioneering indicators for diagnosis and severity stratification of pediatric long COVID DOI Creative Commons
Sylwia D. Tyrkalska, Fernando Pérez-Sánz, Lorena Franco‐Martínez

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Май 31, 2024

Introduction Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), manifests as persistent and often debilitating symptoms enduring well beyond the initial COVID-19 infection. This disease is especially worrying in children since it can seriously alter their development. Presently, a specific diagnostic test definitive biomarker set for confirming long COVID lacking, relying instead on protracted presence Methods We measured levels 13 biomarkers 105 saliva samples (49 from with 56 controls), Pearson correlation coefficient was used to analyse correlations between different salivary biomarkers. Multivariate logistic regression analyses were performed determine which analysed useful discriminate controls, mild severe symptoms. Results Pediatric exhibited increased oxidant decreased antioxidant, immune response, stress-related Correlation unveiled distinct patterns controls. Notably, multivariate pinpointed TOS, ADA2, total proteins, AOPP pivotal variables, culminating remarkably accurate predictive model distinguishing Furthermore, proteins ADA1 instrumental discerning Discussion research sheds light potential clinical utility diagnosing categorizing severity pediatric COVID. It also lays groundwork future investigations aimed at unravelling prognostic value these predicting trajectory affected individuals.

Язык: Английский

Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID DOI Creative Commons

Marzena Romanowska‐Kocejko,

Agata Jędrzejewska, Alicja Braczko

и другие.

Biomedicines, Год журнала: 2024, Номер 12(3), С. 554 - 554

Опубликована: Март 1, 2024

Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial microvascular functions. Recently, it has been shown that infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might lead to morphological metabolic alterations erythrocytes both mild cases coronavirus disease (COVID-19). However, little is known about effects COVID-19 on nucleotide energetics RBCs nor potential contribution metabolism long COVID syndrome. This study aimed analyze levels adenine isolated from patients 12 weeks after SARS-CoV-2 who suffered symptoms relate them function parameters as well rate peripheral tissue oxygen supply. Although absolute quantities were rather slightly changed individuals, many related microcirculatory showed significant correlations RBC adenosine triphosphate (ATP) total (TAN) concentration. A particularly strong relationship was observed between ATP serum ratio arginine asymmetric dimethylarginine—an indicator function. Consistently, positive correlation also ATP/ADP diminished reactive hyperemic response patients, assessed by flow-mediated skin fluorescence (FMSF) technique, which reflected decreased vascular nitric oxide bioavailability. In addition, we have significantly impaired ischemic (IR max IR index), examined FMSF, revealed residual bioavailability epidermal keratinocytes brachial artery occlusion. These ratio, confirming key bioenergetics Taken together, outcomes this indicate dysregulation processes co-occurring dysfunction associated intracellular delivery, may partly explain COVID-specific such physical impairment fatigue.

Язык: Английский

Процитировано

5
Adenosine deaminase promotes goose astrovirus genotype II replication in GEF cells DOI Creative Commons

Saimin Zhai,

Ruixue Li, Keying Liu

и другие.

Poultry Science, Год журнала: 2025, Номер unknown, С. 105176 - 105176

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Follow-up assessment of the microvascular function in patients with long COVID DOI

Marzena Romanowska‐Kocejko,

Alicja Braczko, Agata Jędrzejewska

и другие.

Microvascular Research, Год журнала: 2024, Номер 157, С. 104748 - 104748

Опубликована: Сен. 16, 2024

Язык: Английский

Процитировано

1
Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect DOI
Yu Chang,

Su Min,

Feng Lv

и другие.

Medical Oncology, Год журнала: 2023, Номер 40(10)

Опубликована: Сен. 13, 2023

Язык: Английский

Процитировано

2
Salivary biomarkers as pioneering indicators for diagnosis and severity stratification of pediatric long COVID DOI Creative Commons
Sylwia D. Tyrkalska, Fernando Pérez-Sánz, Lorena Franco‐Martínez

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Май 31, 2024

Introduction Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), manifests as persistent and often debilitating symptoms enduring well beyond the initial COVID-19 infection. This disease is especially worrying in children since it can seriously alter their development. Presently, a specific diagnostic test definitive biomarker set for confirming long COVID lacking, relying instead on protracted presence Methods We measured levels 13 biomarkers 105 saliva samples (49 from with 56 controls), Pearson correlation coefficient was used to analyse correlations between different salivary biomarkers. Multivariate logistic regression analyses were performed determine which analysed useful discriminate controls, mild severe symptoms. Results Pediatric exhibited increased oxidant decreased antioxidant, immune response, stress-related Correlation unveiled distinct patterns controls. Notably, multivariate pinpointed TOS, ADA2, total proteins, AOPP pivotal variables, culminating remarkably accurate predictive model distinguishing Furthermore, proteins ADA1 instrumental discerning Discussion research sheds light potential clinical utility diagnosing categorizing severity pediatric COVID. It also lays groundwork future investigations aimed at unravelling prognostic value these predicting trajectory affected individuals.

Язык: Английский

Процитировано

0