Salivary biomarkers as pioneering indicators for diagnosis and severity stratification of pediatric long COVID DOI Creative Commons
Sylwia D. Tyrkalska, Fernando Pérez-Sánz, Lorena Franco‐Martínez

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 31, 2024

Introduction Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), manifests as persistent and often debilitating symptoms enduring well beyond the initial COVID-19 infection. This disease is especially worrying in children since it can seriously alter their development. Presently, a specific diagnostic test definitive biomarker set for confirming long COVID lacking, relying instead on protracted presence Methods We measured levels 13 biomarkers 105 saliva samples (49 from with 56 controls), Pearson correlation coefficient was used to analyse correlations between different salivary biomarkers. Multivariate logistic regression analyses were performed determine which analysed useful discriminate controls, mild severe symptoms. Results Pediatric exhibited increased oxidant decreased antioxidant, immune response, stress-related Correlation unveiled distinct patterns controls. Notably, multivariate pinpointed TOS, ADA2, total proteins, AOPP pivotal variables, culminating remarkably accurate predictive model distinguishing Furthermore, proteins ADA1 instrumental discerning Discussion research sheds light potential clinical utility diagnosing categorizing severity pediatric COVID. It also lays groundwork future investigations aimed at unravelling prognostic value these predicting trajectory affected individuals.

Language: Английский

Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID DOI Creative Commons

Marzena Romanowska‐Kocejko,

Agata Jędrzejewska, Alicja Braczko

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 554 - 554

Published: March 1, 2024

Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial microvascular functions. Recently, it has been shown that infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might lead to morphological metabolic alterations erythrocytes both mild cases coronavirus disease (COVID-19). However, little is known about effects COVID-19 on nucleotide energetics RBCs nor potential contribution metabolism long COVID syndrome. This study aimed analyze levels adenine isolated from patients 12 weeks after SARS-CoV-2 who suffered symptoms relate them function parameters as well rate peripheral tissue oxygen supply. Although absolute quantities were rather slightly changed individuals, many related microcirculatory showed significant correlations RBC adenosine triphosphate (ATP) total (TAN) concentration. A particularly strong relationship was observed between ATP serum ratio arginine asymmetric dimethylarginine—an indicator function. Consistently, positive correlation also ATP/ADP diminished reactive hyperemic response patients, assessed by flow-mediated skin fluorescence (FMSF) technique, which reflected decreased vascular nitric oxide bioavailability. In addition, we have significantly impaired ischemic (IR max IR index), examined FMSF, revealed residual bioavailability epidermal keratinocytes brachial artery occlusion. These ratio, confirming key bioenergetics Taken together, outcomes this indicate dysregulation processes co-occurring dysfunction associated intracellular delivery, may partly explain COVID-specific such physical impairment fatigue.

Language: Английский

Citations

5
Adenosine deaminase promotes goose astrovirus genotype II replication in GEF cells DOI Creative Commons

Saimin Zhai,

Ruixue Li, Keying Liu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105176 - 105176

Published: April 1, 2025

Language: Английский

Citations

0
Follow-up assessment of the microvascular function in patients with long COVID DOI

Marzena Romanowska‐Kocejko,

Alicja Braczko, Agata Jędrzejewska

et al.

Microvascular Research, Journal Year: 2024, Volume and Issue: 157, P. 104748 - 104748

Published: Sept. 16, 2024

Language: Английский

Citations

1
Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect DOI
Yu Chang,

Su Min,

Feng Lv

et al.

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(10)

Published: Sept. 13, 2023

Language: Английский

Citations

2
Salivary biomarkers as pioneering indicators for diagnosis and severity stratification of pediatric long COVID DOI Creative Commons
Sylwia D. Tyrkalska, Fernando Pérez-Sánz, Lorena Franco‐Martínez

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 31, 2024

Introduction Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), manifests as persistent and often debilitating symptoms enduring well beyond the initial COVID-19 infection. This disease is especially worrying in children since it can seriously alter their development. Presently, a specific diagnostic test definitive biomarker set for confirming long COVID lacking, relying instead on protracted presence Methods We measured levels 13 biomarkers 105 saliva samples (49 from with 56 controls), Pearson correlation coefficient was used to analyse correlations between different salivary biomarkers. Multivariate logistic regression analyses were performed determine which analysed useful discriminate controls, mild severe symptoms. Results Pediatric exhibited increased oxidant decreased antioxidant, immune response, stress-related Correlation unveiled distinct patterns controls. Notably, multivariate pinpointed TOS, ADA2, total proteins, AOPP pivotal variables, culminating remarkably accurate predictive model distinguishing Furthermore, proteins ADA1 instrumental discerning Discussion research sheds light potential clinical utility diagnosing categorizing severity pediatric COVID. It also lays groundwork future investigations aimed at unravelling prognostic value these predicting trajectory affected individuals.

Language: Английский

Citations

0