Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway

The American Journal of Chinese Medicine, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Янв. 29, 2025

Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1–transcription factor NF-E2 p45-related 2 (KEAP1–NRF2) pathway plays crucial role maintaining redox homeostasis and regulating multitude biological processes such as inflammation, homeostasis, metabolic homeostasis. In this paper, we present findings recent studies on KEAP1–NRF2 pathway, which have revealed that it is aberrantly regulated induces oxidative injury variety diseases neurodegenerative diseases, cardiovascular respiratory digestive cancer. Given evidence, targeting highly promising avenue for developing therapeutic strategies thus development appropriate based NRF2 has emerged significant area research interest. This paper highlights an overview current to modulate KEAP1–NRF2, well advances use natural compounds traditional Chinese medicine, with view providing meaningful guidelines drug discovery KEAP1–NRF2. Additionally, discusses challenges associated harnessing target.

Язык: Английский

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The Role of Bioactive Compounds in Human Health and Disease

Nutrients, Год журнала: 2025, Номер 17(7), С. 1170 - 1170

Опубликована: Март 28, 2025

Bioactive compounds, natural chemicals found in foods, herbs, and other sources, have attracted significant attention for their potential to influence health fight disease [...].

Язык: Английский

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The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats

Nutrients, Год журнала: 2025, Номер 17(7), С. 1187 - 1187

Опубликована: Март 28, 2025

Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate potential geroprotective effects of resveratrol and melatonin rats. The animals were treated with these two compounds starting at 3 months age continuing until 1 year or 2 years age. Using a multibiomarker approach, assessed DNA damage, telomere length, oxidative status their urine, liver, kidneys. Despite employing this experimental our results did not provide conclusive evidence across evaluated organs. However, observed sex-dependent differences response treatment. high potency compounds, further research is warranted explore incorporation into daily routines as strategy mitigate ageing-related effects.

Язык: Английский

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Effects of Resveratrol on In Vivo Ovarian Cancer Cells Implanted on the Chorioallantoic Membrane (CAM) of a Chicken Embryo Model

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4374 - 4374

Опубликована: Апрель 16, 2024

Ovarian cancer poses a significant threat to patients in its advanced stages, often with limited treatment options available. In such cases, palliative management becomes the primary approach maintaining reasonable quality of life. Therefore, administration any medication that can benefit without curative option holds potential. Resveratrol, natural compound known for vitro anticancer activities, has generated contrasting results vivo and human studies. this study, we aimed assess effects resveratrol on ovarian cells grown chorioallantoic membrane (CAM) chicken embryos. Two cell lines, OVCAR-8 SKOV-3, were cultured collagen scaffolds four days before being implanted CAM embryos day 7. Different doses applied every two six days. Subsequently, tissues excised, fixed, subjected histological analysis. Some tumours extracted analyse proteins through Western blotting. Our findings indicate specific significantly reduce angiogenic pNF-κB levels, SLUG protein levels by using immunohistochemistry. These suggest may have potential impact behaviour tumours, thereby warranting further consideration as complementary women incurable cancer.

Язык: Английский

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Mechanisms of Phytoremediation by Resveratrol against Cadmium Toxicity

Antioxidants, Год журнала: 2024, Номер 13(7), С. 782 - 782

Опубликована: Июнь 27, 2024

Cadmium (Cd) toxicity poses a significant threat to human health and the environment due its widespread occurrence persistence. In recent years, considerable attention has been directed towards exploring natural compounds with potential protective effects against Cd-induced toxicity. Among these compounds, resveratrol (RV) emerged as promising candidate, demonstrating range of beneficial attributed antioxidant anti-inflammatory properties. This literature review systematically evaluates role RV Cd toxicity, considering various mechanisms action involved. A comprehensive analysis both in vitro vivo studies is conducted provide understanding efficacy mitigating damage. Additionally, this highlights importance phytoremediation strategies addressing contamination, emphasizing enhancing efficiency such remediation techniques. Through integration diverse research findings, underscores therapeutic combating need for further investigation elucidate precise optimize application environmental clinical settings.

Язык: Английский

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Molecular Docking Study and 3D-QSAR Model for Trans-Stilbene Derivatives as Ligands of CYP1B1

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1002 - 1002

Опубликована: Янв. 24, 2025

Scientific research on stilbenes is conducted for their chemopreventive and therapeutic properties. In experimental studies, natural synthetic trans-stilbenes exhibit antioxidant, anti-inflammatory, cardioprotective, anticancer effects. The antitumor activity of some associated with interaction cytochrome P450 family 1, which leads to the inhibition procarcinogen activation. present study, three-dimensional quantitative structure–activity relationship analysis (3D-QSAR) was performed a series forty-one trans-stilbene derivatives identify most significant features molecules responsible CYP1B1 inhibitory activity. developed 3D-QSAR model presented cross-validated correlation coefficient Q2 0.554. model’s predictive ability confirmed by external validation (r2 = 0.808). information provided expected be valuable rational design novel inhibitors.

Язык: Английский

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Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial

European Journal of Nutrition, Год журнала: 2025, Номер 64(2)

Опубликована: Янв. 24, 2025

Язык: Английский

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Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?

Nutrients, Год журнала: 2025, Номер 17(3), С. 504 - 504

Опубликована: Янв. 30, 2025

Objectives: Resveratrol (RES) is well documented for its multiple health benefits, with a notable impact on cancer prevention and therapy. This study aimed to evaluate the effect of RES supplementation oxidative stress in patients head neck (HNC) receiving home enteral nutrition (HEN). Methods: randomized, single-center, open-label involved 72 adult patients, 40 completing intervention. Participants intervention group received 400 mg liposomal daily 12 weeks alongside HEN, while control HEN only. Body composition markers—including total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced (GSH)—were measured at baseline after weeks. Results: Significant increases TAC SOD activity were observed both groups. GPx increased significantly only group. MDA levels rose groups but more pronounced GSH showed no significant changes. Phase angle (PhA) group, change was Conclusions: may enhance defenses, as evidenced by improvements levels, supporting balance HNC HEN. The higher reflect RES’s dual pro-oxidant activities. Additionally, increase PhA suggests potential cellular benefits. These findings highlight complementary clinical oncology, warranting further investigation clarify therapeutic effects care.

Язык: Английский

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Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 28, 2025

Resveratrol (RSV), a polyphenol with anti-aging properties affecting metabolism and energy balance, is considered as mimetic candidate to calorie restriction (CR). However its potential effects on delaying the onset of age-related diseases increasing longevity have not yet been demonstrated in non-obese models close humans such non-human primates. The longitudinal monitoring cognitive motor performances, occurrence pathologies, brain atrophy mortality was performed from adulthood death cohort male grey mouse lemurs (Microcebus murinus, N = 33), all receiving 105 kJ/day food but subset 18 animals RSV (200 mg.kg-1 body weight.day-1). supplementation improved performance at middle age compared control (CTL) animals. Median-lifespan greater RSV-fed (7.9 years 6.4 for CTL) long-term did significantly affect all-cause nor mortality. Also, matter accelerated group old CTL group. Altogether, these results suggest that procures health benefits middle-age has limited might even impair integrity older ages. Long-term resveratrol primate does mimic positive lifespan

Язык: Английский

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Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with complex pathophysiological mechanisms such as oxidative stress, inflammation, apoptosis, and endothelial dysfunction driving progression. MicroRNAs (miRNAs), a class non-coding RNAs, have emerged key regulators gene expression involved in these processes, positioning them potential biomarkers therapeutic targets CVD management. Simultaneously, flavonoids, naturally occurring polyphenolic compounds found various plant-based foods, gained attention for their cardioprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. Recent studies suggest novel intersection between flavonoids miRNAs, where may modulate specific miRNAs implicated pathogenesis. This review explores miRNA modulators, focusing on ability to regulate associated cardiac fibrosis, hypertrophy, vascular inflammation. By bridging targeting, this highlights innovative pathways advancing treatment strategies. Additionally, preclinical clinical evidence supporting interactions is discussed, alongside challenges opportunities developing flavonoid-based therapies. Unlocking synergy could pave way more effective, personalized approaches management, addressing unmet needs contemporary cardiovascular care.

Язык: Английский

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