Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview

Food Science & Nutrition, Год журнала: 2024, Номер 12(11), С. 8715 - 8741

Опубликована: Окт. 16, 2024

Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.

Язык: Английский

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Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study

Oral, Год журнала: 2025, Номер 5(1), С. 19 - 19

Опубликована: Март 13, 2025

Background/Objectives: Bioactive materials are gaining increased popularity as of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there a significant gap in the literature about cementogenic ability bioceramic on periodontal ligament cells. The aim present study was to investigate effect (Biodentine and Bio-C Repair) cementogenesis potential stem cells (PDLSCs). Methods: PDLSCs were isolated using enzymatic digestion approach from sound extracted teeth. Material extracts prepared rubber discs immersed fresh growth medium 24 h at 37 °C. Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) used detect mRNA expression levels markers cementum protein 1 (CEMP1), Cementum attachment (CAP), pathway transforming factor β1(TGF-β1), bone morphogenic 2 (BMP2), inflammatory marker IL-6. Results: Both showed significantly higher gene expressions when compared control groups. Repair Biodentine, except TGF-β1 expression, where both exhibited results. Conclusions: demonstrated Biodentine under tested conditions. Further vivo studies deemed necessary translate findings this into clinical practice.

Язык: Английский

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Fibroblast-derived versican exacerbates periodontitis progression by regulating macrophage migration and inflammatory cytokine secretion

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111755 - 111755

Опубликована: Март 1, 2025

Язык: Английский

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New Insights in Natural Bioactive Compounds for Periodontal Disease: Advanced Molecular Mechanisms and Therapeutic Potential

Molecules, Год журнала: 2025, Номер 30(4), С. 807 - 807

Опубликована: Фев. 10, 2025

Periodontal disease is a chronic inflammatory condition that destroys the tooth-supporting structures due to host's immune response microbial biofilms. Traditional periodontal treatments, such as scaling and root planing, pharmacological interventions, surgical procedures, have significant limitations, including difficulty accessing deep pockets, biofilm recolonization, development of antibiotic resistance. In light these challenges, natural bioactive compounds derived from plants, herbs, other sources offer promising alternative their anti-inflammatory, antioxidant, antimicrobial, tissue-regenerative properties. This review focuses on molecular mechanisms through which compounds, curcumin, resveratrol, epigallocatechin gallate (EGCG), baicalin, carvacrol, berberine, essential oils, Gum Arabic, exert therapeutic effects in disease. Bioactive inhibit critical pathways like NF-κB, JAK/STAT, MAPK while activating protective Nrf2/ARE, reducing cytokine production oxidative stress. They also activity matrix metalloproteinases (MMPs), preventing tissue degradation promoting healing. addition, demonstrated potential disrupt bacterial biofilms by interfering with quorum sensing, targeting cell membranes, enhancing efficacy.Bioactive modulate system shifting balance pro-inflammatory anti-inflammatory responses efferocytosis, helps resolve inflammation supports regeneration. However, despite challenges related poor bioavailability, stability oral cavity, absence large-scale clinical trials need be addressed. Future strategies should prioritize advanced delivery systems nanoparticles hydrogels enhance bioavailability sustain release, alongside long-term studies assess human populations. Furthermore, combining traditional treatments could provide synergistic benefits managing aims explore disease, emphasizing action offering insights into integration conventional therapies for more comprehensive approach health.

Язык: Английский

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Development of an injectable salicylic acid–choline eutectic hydrogel for enhanced treatment of periodontitis

Materials Horizons, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Periodontitis, a chronic inflammatory disease triggered by dental plaque, often presents challenges in management, particularly severe cases where mechanical debridement alone may be insufficient. As result, adjunctive therapies, localized drug delivery systems with both antimicrobial and anti-inflammatory properties, are essential to enhance the efficacy of periodontitis management. In this study, we developed multifunctional hydrogel incorporating salicylic acid-choline deep eutectic solvent (DES) into chitosan/β-glycerol phosphate sodium (CS/GP) matrix for treatment periodontitis. The DES-CS/GP demonstrated favorable physicochemical including gelation injectability, making it highly suitable application oral cavity. effectively inhibited growth key periodontal pathogens, Porphyromonas gingivalis Fusobacterium nucleatum, significantly downregulated expression pro-inflammatory cytokines TNF-α IL-1β vitro. Cytocompatibility assessments showed over 80% cell viability human gingival fibroblasts, epithelial cells, keratinocytes 5 days treated DES-CS/GP, fluorescence microscopy confirming robust cytoskeletal integrity. Furthermore, enhanced permeability through tissues rat model periodontitis, mitigated bone loss, reduced bacterial loads P. g, suppressed tissues. These findings underscore hydrogel's potential as safe effective therapy offering combination antimicrobial, anti-inflammatory, tissue-permeating properties high biosafety ease application.

Язык: Английский

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Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3621 - 3621

Опубликована: Апрель 11, 2025

Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix (ECM) remodeling, regulating a wide range of cellular and immune processes both homeostatic pathological conditions. Host–microbiota interactions play critical role maintaining ECM balance; however, during dysbiosis, this regulation is disrupted, leading to compromised barrier integrity, pathogen translocation into circulation, the development systemic diseases cancer. This review highlights bidirectional relationship between MMP expression/activity microbiota emphasizing tissue-specific alterations activity that contribute disease progression. In addition, it integrates interdisciplinary evidence illustrate MMP-dependent mechanisms underlying various pathologies associated with oral gut microbiome including long-range effects through gut–skin gut–brain axes. Thus, introduces emerging field MatrixBiome, which explores complex ECM, microbiota, host tissues. Finally, also outlines therapeutic strategies modulate levels, either indirectly microbiome-targeted approaches (e.g., prebiotics, probiotics, postbiotics) or directly using inhibitors, offering promising avenues for future clinical interventions.

Язык: Английский

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Effects of Non-Surgical Periodontal Therapy on Glycemic Control in Prediabetes and Diabetes Patients with Stage II–IV Periodontitis as Monitored by Active-Matrix Metalloproteinase-8 Levels

Biomedicines, Год журнала: 2025, Номер 13(4), С. 969 - 969

Опубликована: Апрель 16, 2025

Background/Objectives: Previous research indicates that non-surgical periodontal therapy (NSPT) improves glycemic control in individuals with prediabetes and diabetes who have periodontitis. Few studies demonstrated its effects on mouthrinse active-matrix metalloproteinase-8 (aMMP-8) levels as it relates to control. We assessed the treatment response of stage II–IV periodontitis patients prediabetes, diabetes, normoglycemia, regarding glycated hemoglobin (HbA1c) aMMP-8 using point-of-care kits (PoC). Materials Methods: Eighty-eight adults (11 normoglycemic, 32 prediabetic, 45 type 2 diabetes), aged 25–78, were included. Full-mouth clinical examinations used evaluate their parameters. HbA1c PoC before approximately three months after scaling root planing. Results: There positive parameters, groups. The reduction was significant (p < 0.001) + groups, while decreased significantly In contrast, a non-significant increase mean levels, HbA1c, CAL observed normoglycemia > 0.05). Stage III IV showed for 0.01) compared II, regardless status. Conclusions: Non-surgical health well people living diabetes.

Язык: Английский

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Clinical and Microbiological Periodontal Biofilm Evaluation of Patients with Type I Diabetes

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(22), С. 6724 - 6724

Опубликована: Ноя. 8, 2024

The purpose of this study was to assess the microbial composition and density subgingival plaque samples for periodontal pathogens while correlating values with glycemic control levels via glycated hemoglobin (HbA1c), a type that has chemically linked glucose, in I diabetes individuals who will undergo complex oral rehabilitation through orthodontic treatment implant surgery.

Язык: Английский

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Local Drug Delivery Systems as Novel Approach for Controlling NETosis in Periodontitis

Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1175 - 1175

Опубликована: Сен. 6, 2024

Periodontitis is a chronic inflammation caused by periodontopathogenic bacteria in the dental biofilm, and also involves inflammatory-immune response of host. Polymorphonuclear neutrophils (PMNs) play essential roles bacterial clearance multiple mechanisms, including formation neutrophil extracellular traps (NETs) that retain destroy pathogens. During PD progression, interaction between PMNs, NETs, leads to an exaggerated immune prolonged inflammatory state. As lesion matures, PMNs accumulate periodontal tissues die via NETosis, ultimately resulting tissue injury. A better understanding role associated molecules, pathogenic pathways NET periodontitis, could provide markers NETosis as reliable diagnostic prognostic tools. Moreover, assessment biomarker levels biofluids, particularly saliva or gingival crevicular fluid, be useful for monitoring periodontitis progression treatment efficacy. Preventing excessive accumulation tissues, both controlling NETs' their appropriate removal, key further development more efficient therapeutic approaches. In therapy, local drug delivery (LDD) systems are targeted, enhancing bioavailability active pharmacological agents pocket surrounding time ensure optimal outcome.

Язык: Английский

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Hypoxia-inducible Factor 1α Contributes to Matrix Metalloproteinases 2/9 and Inflammatory Responses in Periodontitis

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Язык: Английский

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