NRF2-mediated regulation of lipid pathways in viral infection
Molecular Aspects of Medicine,
Год журнала:
2024,
Номер
97, С. 101279 - 101279
Опубликована: Май 20, 2024
Язык: Английский
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 16, 2025
Abstract
Reactive
oxygen
species
(ROS)
of
hosts
are
widely
involved
in
intracellular
signaling
and
against
pathogens.
Viruses
manipulate
ROS
homeostasis
as
a
strategy
to
evade
ROS‐mediated
negative
effects
their
infection,
but
the
mechanisms
remain
unclear.
The
economically
important
aquaculture
shrimp,
Litopenaeus
vannamei
,
is
selected
investigate
molecular
mechanism
how
white
spot
syndrome
virus
(WSSV)
regulates
dynamics
enhances
viral
replication.
WSSV
protein
wsv220
binds
repressor
shrimp
nuclear
factor
erythroid
2‐related
2
(LvNrf2),
called
Kelch‐like
ECH‐associated
1
(LvKeap1),
disrupting
LvNrf2/LvKeap1
complex
facilitating
LvNrf2
translocation.
This
activation
causes
up‐regulation
antioxidant
genes,
including
glucose‐6‐phosphate
dehydrogenase
(LvG6PDH),
which
increases
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
glutathione
(GSH)
production,
effectively
eliminating
excessive
ROS.
Moreover,
exploits
establish
positive
feedback
loop
by
up‐regulating
immediate
early
gene
wsv051,
further
expression.
Knockdown
or
LvG6PDH
reduces
replication
host
levels.
Therefore,
hijacks
pathway
maintain
establishes
facilitate
These
findings
reveal
novel
manipulation
suggest
potential
antiviral
strategies
targeting
pathway.
Язык: Английский
Critical Role of Ferroptosis in Viral Infection and Host Responses
Virology,
Год журнала:
2025,
Номер
606, С. 110485 - 110485
Опубликована: Март 8, 2025
Язык: Английский
TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus
Acta Biochimica et Biophysica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
cGAS-STING
signaling
pathway
serves
as
a
pivotal
surveillance
mechanism
for
cytosolic
double-stranded
DNA
(dsDNA)
detection
in
mammalian
systems.
While
STING-mediated
type
I
interferon
production
is
crucial
host
defense,
sustained
activation
of
this
contributes
to
autoimmune
pathologies,
including
systemic
lupus
erythematosus
(SLE).
Maintaining
immune
homeostasis
requires
precise
regulation
STING
activity
prevent
hyperactivation.
Our
study
identifies
TRIM21
novel
positive
regulator
SLE
pathogenesis.
results
demonstrate
that
overexpression
stabilizes
by
suppressing
autophagic
degradation,
whereas
depletion
accelerates
clearance
process.
Mechanistically,
catalyzes
the
K63-linked
polyubiquitylation
selective
autophagy
receptor
p62/SQSTM1,
disrupting
its
interaction
with
STING.
This
post-translational
modification
prevents
sequestration
into
autophagosomes,
thereby
stabilizing
adaptor
protein
and
amplifying
downstream
responses.
findings
reveal
previously
unrecognized
regulatory
circuit
which
orchestrates
cross-talk
between
ubiquitin
control
turnover.
TRIM21-p62
axis
represents
potential
therapeutic
target
attenuating
pathological
STING-dependent
disorders.
work
advances
our
understanding
demonstrating
how
E3
ligase-mediated
modifications
modulate
cargo
recognition
pathways.
identified
provides
new
insights
molecular
interplay
ubiquitylation
degradation
maintaining
innate
balance,
offering
perspectives
developing
targeted
therapies
against
interferonopathies
associated
hyperactivity.
Язык: Английский
The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7042 - 7042
Опубликована: Июнь 27, 2024
Respiratory
viruses
constitute
a
significant
cause
of
illness
and
death
worldwide.
virus-associated
injuries
include
oxidative
stress,
ferroptosis,
inflammation,
pyroptosis,
apoptosis,
fibrosis,
autoimmunity,
vascular
injury.
Several
studies
have
demonstrated
the
involvement
nuclear
factor
erythroid
2-related
2
(Nrf2)
in
pathophysiology
viral
infection
associated
complications.
It
has
thus
emerged
as
pivotal
player
cellular
defense
mechanisms
against
such
damage.
Here,
we
discuss
impact
Nrf2
activation
on
airway
induced
by
respiratory
viruses,
including
coronaviruses,
rhinoviruses,
syncytial
viruses.
The
inhibition
or
deregulation
pathway
induces
tissue
damage
presence
infections.
In
contrast,
demonstrates
protection
organ
injuries.
Clinical
trials
involving
agonists
are
needed
to
define
effect
therapeutics
tissues
organs
damaged
Язык: Английский