The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections DOI Open Access
Arnaud John Kombe Kombe,

Leila Fotoohabadi,

Ravikanth Nanduri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7042 - 7042

Published: June 27, 2024

Respiratory viruses constitute a significant cause of illness and death worldwide. virus-associated injuries include oxidative stress, ferroptosis, inflammation, pyroptosis, apoptosis, fibrosis, autoimmunity, vascular injury. Several studies have demonstrated the involvement nuclear factor erythroid 2-related 2 (Nrf2) in pathophysiology viral infection associated complications. It has thus emerged as pivotal player cellular defense mechanisms against such damage. Here, we discuss impact Nrf2 activation on airway induced by respiratory viruses, including coronaviruses, rhinoviruses, syncytial viruses. The inhibition or deregulation pathway induces tissue damage presence infections. In contrast, demonstrates protection organ injuries. Clinical trials involving agonists are needed to define effect therapeutics tissues organs damaged

Language: Английский

NRF2-mediated regulation of lipid pathways in viral infection DOI
Khursheed Muzammil,

Zahraa Sabah Ghnim,

Ibrahim Saeed Gataa

et al.

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101279 - 101279

Published: May 20, 2024

Language: Английский

Citations

7
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication DOI Creative Commons

Honghui He,

Kai Yuan,

Jia Pan

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Reactive oxygen species (ROS) of hosts are widely involved in intracellular signaling and against pathogens. Viruses manipulate ROS homeostasis as a strategy to evade ROS‐mediated negative effects their infection, but the mechanisms remain unclear. The economically important aquaculture shrimp, Litopenaeus vannamei , is selected investigate molecular mechanism how white spot syndrome virus (WSSV) regulates dynamics enhances viral replication. WSSV protein wsv220 binds repressor shrimp nuclear factor erythroid 2‐related 2 (LvNrf2), called Kelch‐like ECH‐associated 1 (LvKeap1), disrupting LvNrf2/LvKeap1 complex facilitating LvNrf2 translocation. This activation causes up‐regulation antioxidant genes, including glucose‐6‐phosphate dehydrogenase (LvG6PDH), which increases nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH) production, effectively eliminating excessive ROS. Moreover, exploits establish positive feedback loop by up‐regulating immediate early gene wsv051, further expression. Knockdown or LvG6PDH reduces replication host levels. Therefore, hijacks pathway maintain establishes facilitate These findings reveal novel manipulation suggest potential antiviral strategies targeting pathway.

Language: Английский

Citations

0
Critical Role of Ferroptosis in Viral Infection and Host Responses DOI
Qian Mao,

Qin Luo,

Shumei Ma

et al.

Virology, Journal Year: 2025, Volume and Issue: 606, P. 110485 - 110485

Published: March 8, 2025

Language: Английский

Citations

0
TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus DOI Creative Commons
Chen Li,

Ang Ma,

Yu Bai

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The cGAS-STING signaling pathway serves as a pivotal surveillance mechanism for cytosolic double-stranded DNA (dsDNA) detection in mammalian systems. While STING-mediated type I interferon production is crucial host defense, sustained activation of this contributes to autoimmune pathologies, including systemic lupus erythematosus (SLE). Maintaining immune homeostasis requires precise regulation STING activity prevent hyperactivation. Our study identifies TRIM21 novel positive regulator SLE pathogenesis. results demonstrate that overexpression stabilizes by suppressing autophagic degradation, whereas depletion accelerates clearance process. Mechanistically, catalyzes the K63-linked polyubiquitylation selective autophagy receptor p62/SQSTM1, disrupting its interaction with STING. This post-translational modification prevents sequestration into autophagosomes, thereby stabilizing adaptor protein and amplifying downstream responses. findings reveal previously unrecognized regulatory circuit which orchestrates cross-talk between ubiquitin control turnover. TRIM21-p62 axis represents potential therapeutic target attenuating pathological STING-dependent disorders. work advances our understanding demonstrating how E3 ligase-mediated modifications modulate cargo recognition pathways. identified provides new insights molecular interplay ubiquitylation degradation maintaining innate balance, offering perspectives developing targeted therapies against interferonopathies associated hyperactivity.

Language: Английский

Citations

0
The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections DOI Open Access
Arnaud John Kombe Kombe,

Leila Fotoohabadi,

Ravikanth Nanduri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7042 - 7042

Published: June 27, 2024

Respiratory viruses constitute a significant cause of illness and death worldwide. virus-associated injuries include oxidative stress, ferroptosis, inflammation, pyroptosis, apoptosis, fibrosis, autoimmunity, vascular injury. Several studies have demonstrated the involvement nuclear factor erythroid 2-related 2 (Nrf2) in pathophysiology viral infection associated complications. It has thus emerged as pivotal player cellular defense mechanisms against such damage. Here, we discuss impact Nrf2 activation on airway induced by respiratory viruses, including coronaviruses, rhinoviruses, syncytial viruses. The inhibition or deregulation pathway induces tissue damage presence infections. In contrast, demonstrates protection organ injuries. Clinical trials involving agonists are needed to define effect therapeutics tissues organs damaged

Language: Английский

Citations

3