Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Язык: Английский

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Nanoplastics and Neurodegeneration in ALS

Brain Sciences, Год журнала: 2024, Номер 14(5), С. 471 - 471

Опубликована: Май 7, 2024

Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via digestion, inhalation, skin contact. Particles have been documented in all human tissues including breast milk. MNPLs, especially weathered particles, can breach the blood–brain barrier, inducing neurotoxicity. This has non-human species, human-induced pluripotent stem cell lines. Within brain, MNPLs initiate an inflammatory response with pro-inflammatory cytokine oxidative stress generation reactive oxygen mitochondrial dysfunction. Glutamate GABA neurotransmitter dysfunction also ensues alteration excitatory/inhibitory balance favor reduced inhibition resultant neuro-excitation. Inflammation cortical hyperexcitability are key abnormalities involved pathogenic cascade amyotrophic lateral sclerosis (ALS) intricately related to mislocalization aggregation TDP-43, a hallmark ALS. Water many foods contain humans, ingestion main form exposure. Digestion plastics within gut alter their properties, rendering them more toxic, they cause microbiome dysbiosis dysfunctional gut–brain axis. recognized as trigger and/or aggravating factor for ALS associated long (years or decades) preclinical period neonates infants exposed through milk, milk substitutes, toys. endangers time intense neurogenesis establishment neuronal circuitry, setting stage development neurodegeneration later life. MNPL neurotoxicity should be considered yet unrecognized risk diseases.

Язык: Английский

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Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Язык: Английский

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World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

The goal of this review is to highlight the role second-hand smoke (SHS) or environmental tobacco (ETS) and e-cigarette (EC) vapors on brain integrity function during development adulthood, including how it relates increasing risk for age-related neurodegenerative disorders. A systematic literature effect SHS ETS revealed a total 284 372 publications 312 publications, respectively. After taking into account duplicate focused policy, surveys other organs than brain, there are limited studies effects SHS, EC structure function. In review, we examine major constituents in their health, mechanisms by which alters function, behavioral cognitive performance. We hope that will encourage investigators explore further short-as well long-term vapor exposure developing adult better understand its neurodevelopmental disorders diseases ultimately develop therapeutic modalities reduce even prevent short- detrimental health.

Язык: Английский

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Neuroinflammatory Biomarkers in Alzheimer’s Disease: From Pathophysiology to Clinical Implications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11941 - 11941

Опубликована: Ноя. 6, 2024

The identification of neuroinflammation as a critical factor in Alzheimer's disease (AD) has expanded the focus research beyond amyloid-β and tau pathology. neuroinflammatory fluid biomarkers GFAP, sTREM2, YKL-40 have gained attention for their potential early detection monitoring progression. Plasma GFAP demonstrated promise predicting conversion from mild cognitive impairment to AD dementia, while sTREM2 highlights microglial activation, although there are conflicting results regarding its dynamics pathogenesis. Advanced imaging techniques, such PET tracers targeting TSPO MAO-B, also been developed visualize glial activation vivo, offering spatial temporal insights into processes. However, clinical implementation these faces challenges due lack specificity, many them can be elevated other conditions. Therapeutic strategies emerging, with TREM2-targeting therapies antidiabetic drugs like GLP-1 receptor agonists showing modulating activity. Nevertheless, complexity neuroinflammation, which encompasses both protective harmful responses, necessitates further fully unravel role optimize therapeutic approaches AD.

Язык: Английский

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Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102519 - 102519

Опубликована: Сен. 1, 2024

Язык: Английский

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The Impact of Caregiver Affiliate Stigma on the Psychosocial Well-Being of Caregivers of Individuals with Neurodegenerative Disorders: A Scoping Review

Healthcare, Год журнала: 2024, Номер 12(19), С. 1957 - 1957

Опубликована: Окт. 1, 2024

Background. Caregiver affiliate stigma concerning neurodegenerative disorders (NDDs) profoundly affects caregivers' well-being, though its full impact remains to be fully elucidated. Objectives. This scoping review aims consolidate the current knowledge on caregiver related NDDs, explore connection psychosocial and pinpoint gaps in existing research. Methods. Adhering PRISMA-ScR guidelines, a comprehensive search of five databases was conducted for peer-reviewed, English language studies focusing caregiver-affiliated relation NDDs. Results. The initial yielded 9033 articles, with 19 meeting inclusion criteria after rigorous screening. Bronfenbrenner's ecological systems theory employed analyze various conceptualizations, including public, courtesy, affiliate, family stigma. Analysis revealed correlation between elevated levels increased burden, deteriorated mental health outcomes, diminished quality life. internalization found vary across demographic groups, influenced by factors such as education level social support. also highlighted mediating role coping strategies protective function support against internalization. Conclusions, These findings underscore necessity targeted, culturally sensitive interventions that address multiple levels. contributes more nuanced understanding laying groundwork future research intervention development aimed at enhancing well-being diverse cultural contexts.

Язык: Английский

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Endoplasmic Reticulum Stress in Neurodegenerative Diseases

Journal of dementia and Alzheimer's disease, Год журнала: 2024, Номер 1(2), С. 87 - 97

Опубликована: Окт. 15, 2024

Endoplasmic reticulum (ER) stress is a detrimental cellular phenomenon in the cells and activated by accumulation of unfolded or misfolded proteins ER. The protein activates response (UPR), an adaptive mechanism designed to mitigate enhancing ER’s protein-folding capacity protecting from apoptotic stimuli neuroinflammation neurodegenerative diseases. However, chronic ER prolonged activation UPR can have adverse effects, including pro-apoptotic inflammatory signaling pathways, which contribute development progression disorders. Neurodegenerative diseases are complex devastating conditions with underlying pathogenesis that not fully understood. Genetic mutations leading phosphorylated tau amyloid-beta induce stress, resulting neuronal death. Several studies reported involvement increased Thus, inhibiting targeting their associated pathways represent significant area research interest. This review discusses critical molecules involved mechanisms diseases, latest developments available inhibitors. Despite extensive inhibitors over years, only limited number been approved as pharmaceutical drugs. There remains need for effective provide efficient treatments Alzheimer’s disease.

Язык: Английский

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Neuroprotective properties of zinc oxide nanoparticles: therapeutic implications for Parkinson's disease

Bioscience Reports, Год журнала: 2024, Номер 44(11)

Опубликована: Ноя. 1, 2024

Parkinson's disease (PD) significantly affects millions of people worldwide due to the progressive degeneration dopamine-producing neurons in substantia nigra pars compacta. Despite extensive research efforts, effective treatments that can halt or reverse progression PD remain elusive. In recent years, nanotechnology has emerged as a promising new avenue for addressing this challenge, with zinc oxide nanoparticles (ZnO-NPs) standing out their therapeutic potential. ZnO-NPs have shown remarkable promise neuroprotection through several key mechanisms. The multifaceted properties suggest they could play crucial role intervening across various fundamental mechanisms implicated PD. By targeting these mechanisms, offer insights and potential strategies managing treating This review aims provide thorough examination molecular which exert neuroprotective effects. It highlights innovative agents outlines directions future explore harness full capabilities.

Язык: Английский

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Analysis of total RNA as a potential biomarker of Parkinson’s disease in silico

International Journal of Immunopathology and Pharmacology, Год журнала: 2025, Номер 39

Опубликована: Янв. 1, 2025

Knowledge about total RNA molecules in Parkinson’s disease is limited. This gene expression profiling study was conducted with a preclinical experimental design using mouse model to examine the molecular-biological characteristics and pathological implication of interaction silico. In silico analysis molecules, Gene Expression Omnibus database, published results, preliminary findings available patient samples apply. The potential signaling network effect predicted confirmed. research consists four parts. At first, we analyzed control MPTP groups. second part, FVB-N MPTP. third controls. fourth MTPT separately. constructed contains RNA, where Kyoto Encyclopedia Genes Genomes database showed that genes from pathway are involved development complications male female rats. Identified altered signaling. There direct interconnection interdependence interactions network. Results identified significant total-RNA connect other molecules. shows upregulated downregulated Preliminary data interact genes, they applicable course monitoring, shedding light on how factors impact offering strategies for management.

Язык: Английский

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