Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones
Diseases,
Год журнала:
2025,
Номер
13(1), С. 7 - 7
Опубликована: Янв. 2, 2025
Urinary
stones
(urolithiasis)
have
been
categorized
as
kidney
(renal
calculus),
ureteric
(ureteral
calculus
and
ureterolith),
bladder
(bladder
urethral
(urethral
calculus);
however,
the
mechanisms
underlying
their
promotion
related
injuries
in
glomerular
tubular
cells
remain
unclear.
Although
lifestyle-related
diseases
(LSRDs)
such
hyperglycemia,
type
2
diabetic
mellitus,
non-alcoholic
fatty
liver
disease/non-alcoholic
steatohepatitis,
cardiovascular
disease
are
risk
factors
for
urolithiasis,
Recently,
heat
shock
protein
90
(HSP90)
on
membrane
of
HK-2
human
proximal
epithelium
has
associated
with
adhesion
urinary
cytotoxicity.
Further,
HSP90
pancreatic
breast
can
be
modified
by
various
advanced
glycation
end-products
(AGEs),
thus
affecting
function.
Hypothesis
1:
We
hypothesized
that
HSP90s
on/in
types
AGEs,
they
may
affect
functions
it
a
key
to
reveal
LSRDs
urolithiasis.
2:
considered
possibility
Japanese
traditional
medicines
urolithiasis
inhibit
AGE
generation.
Of
Choreito
Urocalun
(the
extract
Quercus
salicina
Blume/Quercus
stenophylla
Makino)
used
clinic,
is
Kampo
medicine,
while
characteristic
medicine.
As
contains
quercetin,
hesperidin,
p-hydroxy
cinnamic
acid,
which
generation,
we
generation
AGE-modified
cells.
Язык: Английский
The Advanced Glycation End-Products (AGE)–Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3707 - 3707
Опубликована: Апрель 14, 2025
The
AGE
(advanced
glycation
end-products)–RAGE
(receptor
for
AGE)
system
is
a
pro-inflammatory
pathway
that
contributes
to
the
pathogenesis
of
obesity
and
obesity-related
cardiovascular
disorders
(CVD).
Circulating
soluble
form
RAGE
(sRAGE)
has
been
suggested
as
potential
biomarker
CVD
related
obesity.
In
this
study,
we
aim
(1)
summarize
current
knowledge
about
role
in
onset
progression
CVD,
(2)
discuss
AGE–RAGE
promoting
linking
(3)
highlight
available
strategies
reducing
activation
associated
beneficial
effects.
Язык: Английский
WormCNN-Assisted Establishment and Analysis of Glycation Stress Models in C. elegans: Insights into Disease and Healthy Aging
Yan Pan,
Zhihang Huang,
Hongxia Cai
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9675 - 9675
Опубликована: Сен. 6, 2024
Glycation
Stress
(GS),
induced
by
advanced
glycation
end-products
(AGEs),
significantly
impacts
aging
processes.
This
study
introduces
a
new
model
of
GS
Caenorhabditis
elegans
feeding
them
Escherichia
coli
OP50
cultured
in
glucose-enriched
medium,
which
better
simulates
human
dietary
compared
to
previous
single
protein–glucose
cross-linking
methods.
Utilizing
WormCNN,
deep
learning
model,
we
assessed
the
health
status
and
calculated
Healthy
Aging
Index
(HAI)
worms
with
or
without
GS.
Our
results
demonstrated
accelerated
group,
evidenced
increased
autofluorescence
altered
gene
expression
key
regulators,
daf-2
daf-16.
Additionally,
observed
elevated
pharyngeal
pumping
rates
AGEs-fed
worms,
suggesting
an
addictive
response
similar
patterns.
highlights
profound
effects
on
worm
underscores
critical
role
computer
vision
accurately
assessing
aiding
establishment
disease
models.
The
findings
provide
insights
into
glycation-induced
offer
comprehensive
approach
studying
Язык: Английский
Slot Blot- and Electrospray Ionization–Mass Spectrometry/Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry-Based Novel Analysis Methods for the Identification and Quantification of Advanced Glycation End-Products in the Urine
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9632 - 9632
Опубликована: Сен. 5, 2024
Proteins,
saccharides,
and
low
molecular
organic
compounds
in
the
blood,
urine,
saliva
could
potentially
serve
as
biomarkers
for
diseases
related
to
diet,
lifestyle,
use
of
illegal
drugs.
Lifestyle-related
(LSRDs)
such
diabetes
mellitus
(DM),
non-alcoholic
steatohepatitis,
cardiovascular
disease,
hypertension,
kidney
osteoporosis
develop
into
life-threatening
conditions.
Therefore,
there
is
an
urgent
need
their
early
diagnosis.
Advanced
glycation
end-products
(AGEs)
are
associated
with
LSRDs
may
induce/promote
LSRDs.
The
presence
AGEs
body
fluids
represent
a
biomarker
Urine
samples
be
used
detecting
AGEs,
urine
collection
convenient
non-invasive.
However,
detection
identification
AGE-modified
proteins
challenging,
concentrations
might
extremely
low.
To
address
this
issue,
we
propose
new
analytical
approach.
This
strategy
employs
method
previously
introduced
by
us,
which
combines
slot
blotting,
our
unique
lysis
buffer
named
Takata’s
buffer,
polyvinylidene
difluoride
membrane,
conjunction
electrospray
ionization-mass
spectrometry
(ESI)/matrix-assisted
laser
desorption/ionization-mass
(MALDI-MS).
novel
detect
proteins,
peptides,
free-type
samples.
Язык: Английский
Antioxidant and anti-glycation activities of Mandevilla velutina extract and effect on parasitemia levels in Trypanosoma cruzi experimental infection: in vivo, in vitro and in silico approaches
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
unknown, С. 118994 - 118994
Опубликована: Окт. 1, 2024
Язык: Английский