Clinical Nuclear Medicine,
Год журнала:
2023,
Номер
48(12), С. e572 - e573
Опубликована: Сен. 21, 2023
Recently
developed
radiolabeled
FAPI
(fibroblast-activation
protein
inhibitors)
have
attracted
researcher's
attention
in
diagnosing
various
tumors
because
of
its
high
specificity
and
better
tumor-to-background
ratio.
Increasing
use
68
Ga-FAPI
PET/CT
has
resulted
reporting
incidental
benign
findings
as
well.
We
hereby
present
a
case
suspected
carcinoma
stomach
showing
increased
uptake
primary
tumor
well
subchondral
cysts
bilateral
shoulder
joints
right
hip
joint
on
PET
CT
scan.
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 775 - 775
Опубликована: Март 22, 2025
Immune-mediated
inflammatory
diseases
(IMIDs)
are
characterized
by
chronic
systemic
inflammation
and
multi-organ
involvement.
Fibrosis
formation
in
IMIDs
can
cause
tissue
destruction
subsequently
organ
malfunction.
Fibroblast
activation
protein
inhibitor
positron
emission
tomography/computed
tomography
(FAPi
PET/CT)
represents
a
novel
imaging
technique
that
holds
great
potential
to
visualize
vivo
fibrosis.
We
here
provide
an
overview
of
available
evidence
on
FAPi
PET/CT
fibrosis
various
IMIDs,
including
interstitial
lung
diseases,
immunoglobulin
G4-related
cardiovascular
kidney
gastrointestinal
diseases.
demonstrates
high
sensitivity
detecting
early
fibrosis,
correlating
with
disease
severity,
across
different
showing
superiority
compared
conventional
modalities.
Although
might
be
useful
tool
assess
formation,
thereby
aiding
grading
severity
staging,
future
studies
should
include
larger
sample
sizes
broad
variety
emphasis
the
optimization
protocols
further
validate
its
diagnostic
value.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 716 - 716
Опубликована: Май 31, 2024
The
role
of
fibroblast
activation
protein
inhibitor
(FAPI)
positron
emission
tomography/computed
tomography
(PET/CT)
is
emerging
for
the
assessment
non-oncological
diseases,
such
as
inflammatory
and
infectious
even
if
evidence
in
literature
still
its
initial
phases.
We
conducted
a
systematic
search
Scopus,
PubMed/MEDLINE,
Embase,
Cochrane
library
databases
studies
published
before
31
December
2023
reporting
disease
imaging
with
FAPI
PET/CT.
included
twenty-one
total
1046
patients.
most
frequent
studied
was
lung
interstitial
disease,
investigated
six
200
patients,
followed
by
bone
joint
diseases
two
185
IgG4-related
53
Crohn’s
30
Despite
heterogeneity
terms
study
design
technical
features,
PET/CT
showed
high
detection
rate
diagnostic
role.
Moreover,
when
compared
2-[18F]FDG
(n
=
7
studies),
seems
to
have
better
performances.
presence
chronic
inflammation
tissue
remodeling,
typical
immune-mediated
conditions,
may
be
underlying
mechanism
uptake.
Molecular Cancer Research,
Год журнала:
2023,
Номер
21(10), С. 995 - 1009
Опубликована: Июнь 21, 2023
Abstract
After
an
initial
response
to
chemotherapy,
tumor
relapse
is
frequent.
This
event
reflective
of
both
the
spatiotemporal
heterogeneities
microenvironment
as
well
evolutionary
propensity
cancer
cell
populations
adapt
variable
conditions.
Because
cause
this
adaptation
could
be
genetic
or
epigenetic,
studying
phenotypic
properties
such
metabolism
useful
it
reflects
molecular,
cellular,
and
tissue-level
dynamics.
In
triple-negative
breast
(TNBC),
characteristic
metabolic
phenotype
a
highly
fermentative
state.
However,
during
treatment,
spatial
temporal
dynamics
landscape
are
unstable,
with
surviving
taking
on
variety
states.
Thus,
longitudinally
imaging
provides
promising
approach
inform
therapeutic
strategies,
monitor
treatment
responses
understand
mitigate
recurrence.
Here
we
summarize
some
examples
plasticity
reported
in
TNBC
following
chemotherapy
review
current
techniques
available
monitoring
clinically
preclinically.
The
ensemble
technologies
describe
has
distinct
attributes
that
make
them
uniquely
suited
for
particular
length
scale,
biological
model,
and/or
features
can
captured.
We
focus
highlight
potential
each
these
technological
advances
understanding
evolution-based
resistance.
The
diagnosis
of
a
periprosthetic
joint
infection
(PJI)
is
always
difficult
point
in
research
on
the
surgery
joints.
current
diagnostic
criteria
include
comprehensive
analysis
multiple
tests;
however,
there
are
no
effective
visual
examinations
yet
that
can
differentiate
between
aseptic
loosening
and
PJI.This
case
report
describes
four
patients
with
symptomatic
total
hip
arthroplasty
(THA),
two
cases
infection.
Although
were
correctly
diagnosed
by
tissue
culture,
preoperative
tests
pathological
examination
could
not
effectively
distinguish
an
from
non-infection.
Based
preclinical
study
theoretical
feasibility,
gallium-68
(68Ga)-labeled
fibroblast
activation
protein
inhibitor
positron
emission
tomography/computed
tomography
(68Ga-FAPI
PET/CT)
was
performed.
Through
68Ga-FAPI
PET/CT
scanning,
only
causes
but
lesions
also
located.When
lesion
located
bone
prosthesis,
(PJI).
has
clear
advantages
over
routine
prospective
application
detecting
PJI.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 23, 2024
AbstractObjective:This
study
aimed
to
compare
and18FDGPET/CT
in
patients
who
develop
bone
metastases
due
various
cancers
and
investigate
the
prognostic
significance
of
68FAPI-PET/CT
SUVmax
value
for
survival.
Methods:Patients
with
underwent
both
68Ga-FAPI
PET/CTand18FDGPET/CT
within
a
1-week
period
were
included
this
retrospective
study.
The
effect
lesions
on
overall
survival
was
analyzed.
Results:A
total
75
eligible
139
median
age
55(30–83)
48
(64%)
newly
diagnosed.
primary
lesion
PET/CT
higher
than
18FDGPET/CT
(10.75
versus
6.7).
Bone
median(IQR)
7.8(4.6–13.2),
5.9(3.8–8.2).
More
detected
18FDGPET/CT(median
IQR
4
[1–9]
2
[1–6](p=0.014).
extra
observed
mostly
sclerotic
lesions(p
=
0.001).68Ga-FAPI
significantly
vertebra
thorax
lesions(p=0.011
p=0.018,
respectively).
While
affected
OS,
did
not
affect
OS
(p<0.001
p=0.079,
In
ROC
analysis,
cut-off
>7.7
found
OS(AUC:0.619).
group
above
worse
that
below
(32
45)
months
(p=0.002).
multivariate
analysis
an
important
parameter,as
well
as
cancer
subtype,
ALP
level,
disease
occurrence.
Conclusions:68Ga-FAPI
more
values
cancers.
regardless
subtype.
Positron
emission
tomography/computed
tomography
(PET/CT)
using
18F-fluorodeoxyglucose
([18F]-FDG)
is
a
widely
adopted
imaging
modality
for
detecting
hypermetabolic
lesions.
However,
emerging
positron-emitting
tracers,
such
as
radiopharmaceuticals
featuring
fibroblast
activation
protein
(FAP)
inhibitors
(FAPI)
labeled
with
[18F]
or
[68Ga],
have
opened
new
avenues
in
nuclear
medicine.
This
case
report
focuses
on
the
unique
behavior
of
[68Ga]-FAPI
bilateral
gluteal
myositis
ossificans,
an
infrequent
condition
characterized
by
soft
tissue
ossification.
A
45-year-old
woman
gastric
adenocarcinoma
underwent
subtotal
gastrectomy
and
received
neoadjuvant
adjuvant
chemotherapy;
PET
revealed
metastatic
processes
unexpected
avid
intramuscular
ossifications
pelvic
thigh
muscles.
Even
though
there
was
no
history
trauma,
patient
diagnosed
marked
non-cancerous
ectopic
ossifications.
Diagnosis
relies
history,
radiology,
and/or
histology.
FAPI
imaging,
increasingly
used
inflammatory
infectious
diseases,
can
exhibit
uptake
benign
conditions,
including
those
involving
bones
joints.
first
to
document
incidental
ossificans.
The
robust
activity
ossificans
highlights
importance
considering
context
calcifications
intense
uptake.
