The Complex Association between COPD and COVID-19
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(11), С. 3791 - 3791
Опубликована: Май 31, 2023
Chronic
obstructive
pulmonary
disease
(COPD)
is
significant
cause
of
morbidity
and
mortality
worldwide.
There
mounting
evidence
suggesting
that
COPD
patients
are
at
increased
risk
severe
COVID-19
outcomes;
however,
it
remains
unclear
whether
they
more
susceptible
to
acquiring
SARS-CoV-2
infection.
In
this
comprehensive
review,
we
aim
provide
an
up-to-date
perspective
the
intricate
relationship
between
COVID-19.
We
conducted
a
thorough
review
literature
examine
regarding
susceptibility
infection
severity
their
outcomes.
While
most
studies
have
found
pre-existing
associated
with
worse
outcomes,
some
yielded
conflicting
results.
also
discuss
confounding
factors
such
as
cigarette
smoking,
inhaled
corticosteroids,
socioeconomic
genetic
may
influence
association.
Furthermore,
acute
management,
treatment,
rehabilitation,
recovery
in
how
public
health
measures
impact
care.
conclusion,
while
association
complex
requires
further
investigation,
highlights
need
for
careful
management
during
pandemic
minimize
Язык: Английский
Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Abstract
Host‐directed
therapies
(HDTs)
have
emerged
as
a
promising
strategy
to
combat
viral
infections
by
modifying
host
factors
and
immune
responses
restrict
replication
improve
patient
outcomes.
This
review
summarizes
the
latest
advances
future
potential
of
HDTs
in
antiviral
therapy.
With
developments
genomics
proteomics,
new
targets
essential
for
been
identified.
Gene‐editing
tools,
such
CRISPR‐Cas9,
enable
precise
manipulation
genes
linked
processes,
paving
way
innovative
HDTs.
Emerging
approaches,
including
RNA
interference
interference,
further
demonstrate
specifically
modify
inhibit
replication.
Additionally,
probiotics
are
being
explored
their
capacity
enhance
modulate
gut
microbiota,
offering
natural
safe
method
boosting
defenses.
Despite
these
advancements,
significant
challenges
remain,
particularly
deciphering
complex
host–virus
interactions
ensuring
safety
efficacy
therapies.
Continued
research
clinical
evaluation
realize
full
provides
comprehensive
overview
current
HDT
strategies,
emphasizing
promise
shaping
interventions.
Язык: Английский
The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection
Archives of Dermatological Research,
Год журнала:
2024,
Номер
316(6)
Опубликована: Май 31, 2024
Abstract
Scientists
from
various
areas
of
the
world
indicate
in
their
studies
that
skin
lesions
occur
course
infection
with
SARS-CoV-2
virus.
This
article
is
a
review
most
frequently
described
cutaneous
manifestations
virus
and
potential
pathophysiology
development,
as
well
information
on
abnormalities
histopathological
tests.
The
describes
impact
some
factors
related
to
COVID-19
pandemic
exacerbation
chronic
dermatological
diseases.
work
was
constructed
basis
142
research
studies,
reviews,
meta-analyses,
focusing
methods
materials
used
individual
works
results
conclusions
resulting
them.
Some
may
be
prognostic
marker
disease
also
prodromal
symptom
or
only
infection.
Stress
exacerbate
A
correlation
observed
between
type
patient’s
age.
occurrence
diseases
influenced
by
drugs
treat
infections
caused
SARS-CoV-2.
relationship
ethnic
origin
occurring
COVID-19.
There
need
further
diagnose
learn
detailed
pathomechanism
order
better
understand
essence
find
an
appropriate
treatment
method.
Язык: Английский
The role of inflammatory gene polymorphisms in severe COVID-19: a review
Virology Journal,
Год журнала:
2024,
Номер
21(1)
Опубликована: Дек. 20, 2024
The
COVID-19
pandemic,
caused
by
the
novel
coronavirus
SARS-CoV-2,
has
profoundly
impacted
global
healthcare
systems
and
spurred
extensive
research
efforts
over
past
three
years.
One
critical
aspect
of
disease
is
intricate
interplay
between
virus
host
immune
response,
particularly
role
inflammatory
gene
expression
in
severe
COVID-19.
While
numerous
previous
studies
have
explored
genetic
polymorphisms
COVID-19,
specifically
focusing
on
genes
their
associations
with
severity
remains
limited.
This
review
explores
relationship
outcomes
within
key
genes.
By
investigating
impact
variations
responses,
which
include
cytokine
production
downstream
signalling
pathways,
we
aim
to
provide
a
comprehensive
overview
how
contribute
variability
presentation.
Through
an
in-depth
analysis
existing
literature,
shed
light
potential
therapeutic
targets
personalized
approaches
that
may
enhance
our
understanding
pathogenesis
treatment
strategies.
Язык: Английский
Universal mRNA-based HIV Vaccine for Acute and Latent Infections
Опубликована: Март 18, 2024
Human
Immunodeficiency
Virus
(HIV)
infection
and
its
latent
recurrent
make
vaccine
development
a
significant
challenge
for
traditional
vaccines;
however,
the
mRNA
delivery
of
multiepitope
antigens
capable
creating
antibodies
against
surface
proteins
HIV-1
HIV-2
along
with
their
respective
Nef
proteins,
responsible
can
bring
most
effective,
as
well
affordable
solution
to
unresolved
epidemics
HIV.
In
this
paper,
we
present
complete
design
prevent
acute
infections
inactivate
that
block
MHC-1
MHC-2
pathways
hide
virus
later
reinfection.
Язык: Английский
Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 1897 - 1917
Опубликована: Март 1, 2024
DPP4
(Dipeptidyl-peptidase
4)
a
versatile
protease,
emerges
as
prominent
player
in
soluble
and
membrane-bound
forms.Its
heightened
expression
has
been
intimately
linked
to
the
initiation
severity
of
diverse
autoimmune
diseases,
spanning
rheumatoid
arthritis,
systemic
lupus
erythematosus,
sclerosis
(SSc),
inflammatory
bowel
disease,
diabetes,
even
SARS-CoV-2
infection.Operating
co-stimulator
T
cell
activity,
propels
proliferation
by
binding
adenosine
deaminase
(ADA),
thereby
augmenting
breakdown
adenosine-an
influential
inhibitor
proliferation.However,
discovery
wide
range
inhibitors
shown
promise
alleviating
these
diseases'
signs,
symptoms,
severity.The
available
have
demonstrated
significant
effectiveness
blocking
activity.Based
on
characterization
their
mechanisms,
three
distinct
groups
identified:
saxagliptin,
alogliptin,
sitagliptin,
each
representing
different
class.Elevated
levels
angiotensin-converting
enzyme
2
(ACE2)
are
associated
with
producing
various
coronavirus
peptidases.With
its
anti-inflammatory
properties,
Sitagliptin
may
assist
COVID-19
patients
preventing
managing
cytokine
storms.This
comprehensive
review
delves
into
burgeoning
realm
therapeutic
interventions
for
diseases.With
discerning
focus
efficacy,
investigation
sheds
light
remarkable
capacity
alleviate
burdensome
signs
symptoms
intricately
conditions.
Язык: Английский
How could our genetics impact COVID-19 vaccine response?
Expert Review of Clinical Immunology,
Год журнала:
2024,
Номер
20(9), С. 1027 - 1039
Опубликована: Апрель 27, 2024
Introduction
The
COVID-19
pandemic,
caused
by
the
SARS-CoV-2
virus,
has
posed
unprecedented
global
health
challenges
since
its
emergence
in
December
2019.
rapid
availability
of
vaccines
been
estimated
to
save
millions
lives,
but
there
is
variation
how
individuals
respond
vaccines,
influencing
their
effectiveness
at
an
individual,
and
population
level.
Язык: Английский
Epidemiological studies of COVID-19 disease
International Journal of Health Sciences,
Год журнала:
2023,
Номер
7(S1), С. 990 - 1030
Опубликована: Июнь 1, 2023
The
Chinese
population
having
epidemiological
link
with
wholesale
market
of
seafood
develop
respiratory
illness
pneumonia
like
clinical
presentations
in
Hubei
Province,
Wuhan
City,
recently
December
2019.
Laboratory
results
revealed
a
novel
coronavirus
that
was
named
severe
acute
syndrome
coronavirus-2
(SARS
CoV-2)
and
disease
it
caused
given
name
2019
(COVID-19).
COVID-19
turn
out
to
be
third
outbreak
human
pathogenic
coronaviruses
first
pandemic
21st
century.
previous
proved
merely
as
tip
iceberg
after
emergence
identified
SARS-CoV-2
potential
status
significantly
the
concealed
capabilities
virulence
contagiousness
betacoronaviruses
group.
aim
this
review
is
discuss
origin
COVID-19,
transmission
patterns,
susceptible
hosts,
factors
increase
severity,
nucleic
acid
base
diagnosis,
mortality
morbidity
rates
therapeutic
option
against
COVID-19.
diagnostic
methods
microarray
RNA-targeting
CRISPR
were
adopted
for
diagnosis
advancing
them
further
rapid
accurate
detection
high
throughput.
Язык: Английский