Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications

Neuroscience, Год журнала: 2024, Номер 548, С. 9 - 26

Опубликована: Апрель 30, 2024

Язык: Английский

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Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

Heliyon, Год журнала: 2024, Номер 10(1), С. e24050 - e24050

Опубликована: Янв. 1, 2024

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that causes significant neurodegeneration. Methylmercury (MeHg) neurotoxin induces axonal neurodegeneration and motor nerve degeneration by destroying oligodendrocytes, degenerating white matter, inducing apoptosis, excitotoxicity, reducing myelin basic protein (MBP). This study examines the inhibition of SIRT-1 (silence information regulator 1), Nrf-2 (nuclear factor E2-related 2), HO-1 (heme oxygenase TDP-43 (TAR-DNA-binding 43) accumulation in context ALS, as well modulation these proteins icariin (15 30 mg/kg, orally), glycoside flavonoid with neuroprotective properties. Neuroprotective activates SIRT-1, Nrf-2, HO-1, mitigating inflammation neuronal injury disorders. In-vivo in-silico testing experimental ALS models confirmed efficacy modulating cellular targets. The addition sirtinol 10 an inhibitor helps determine effectiveness icariin. In this study, we also examined neurobehavioral, neurochemical, histopathological, LFB (Luxol fast blue) markers various biological samples, including Cerebrospinal fluid (CSF), blood plasma, brain homogenates (Cerebral Cortex, Hippocampus, Striatum, mid-brain, Cerebellum). These results demonstrate administration ameliorates mechanism underlying benefits likely related to regulating signaling pathways.

Язык: Английский

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Association Between Diffusion Tensor Imaging Measurements and Cognitive Performances in People with Multiple Sclerosis: A Systematic Review and Meta-analysis

Multiple Sclerosis and Related Disorders, Год журнала: 2025, Номер 94, С. 106261 - 106261

Опубликована: Янв. 6, 2025

Язык: Английский

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Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5161 - 5193

Опубликована: Янв. 3, 2024

Язык: Английский

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Microfluidics as diagnostic tools

Clinica Chimica Acta, Год журнала: 2024, Номер 556, С. 117841 - 117841

Опубликована: Фев. 22, 2024

Язык: Английский

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Matrine mediated neuroprotective potential in experimental multiple sclerosis: Evidence from CSF, blood markers, brain samples and in-silico investigations

Journal of Neuroimmunology, Год журнала: 2023, Номер 384, С. 578200 - 578200

Опубликована: Сен. 16, 2023

Язык: Английский

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Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(6), С. 3867 - 3895

Опубликована: Янв. 16, 2024

Язык: Английский

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Gut dysbiosis and neurological modalities: An engineering approach via proteomic analysis of gut-brain axis

Advances in protein chemistry and structural biology, Год журнала: 2024, Номер unknown, С. 199 - 248

Опубликована: Янв. 1, 2024

Язык: Английский

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Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway

Drug Development Research, Год журнала: 2025, Номер 86(1)

Опубликована: Янв. 5, 2025

ABSTRACT The central nervous system is affected by multiple sclerosis (MS), a chronic autoimmune illness characterized axonal destruction, demyelination, and inflammation. This article summarizes the state of field, highlighting its complexity significant influence on people's quality life. research employs network pharmacological approach, integrating systems biology, bioinformatics, pharmacology to identify biomarkers associated with MS. Utilizing Nelumbo Nucifera (Lotus) seeds, study involves toxicity assessments, biomolecule screening, target prediction. Advanced computational methodologies are employed, including molecular docking dynamic simulations, assess potential therapeutic interactions. Biomolecule screening identifies eight active compounds from Lotus Anonaine Liriodenine. Target prediction reveals 264 common targets MS‐related genes. Protein‐protein interaction analysis establishes complex network, identifying like SRC AKT1. Bioinformatics enrichment uncovers candidates pathways. A Biomolecule‐Target‐Pathway diagram visualizes interactions, Liriodenine exhibiting strong binding affinities in studies. Molecular dynamics simulations provide insights into In conclusion, through advanced techniques, it unveils therapies, pathways, bridging predictions practical applications. show promise curbing MS biomarkers.

Язык: Английский

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Disruptions in cellular communication: Molecular interplay between glutamate/NMDA signalling and MAPK pathways in neurological disorders

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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