Interleukin
(IL)-23
is
a
central
proinflammatory
cytokine
with
broad
range
of
effects
on
immune
responses.
The
pathological
consequences
excessive
IL-23
signaling
have
been
linked
to
its
ability
promote
the
production
inflammatory
mediators
such
as
IL-17,
IL-22
by
stimulating
differentiation
and
proliferation
T
helper
type
17
(Th17
cells).
Emerging
evidence
suggests
potential
pro-fibrotic
role
for
in
development
chronic
autoimmune
diseases
characterized
intense
fibrosis.
In
this
review,
we
summarized
biological
features
gathered
recent
research
fibrotic
conditions,
which
could
provide
theoretical
basis
clinical
targeting
drug
development.
Heliyon,
Год журнала:
2024,
Номер
10(1), С. e24050 - e24050
Опубликована: Янв. 1, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
fatal
neurodegenerative
disease
that
causes
significant
neurodegeneration.
Methylmercury
(MeHg)
neurotoxin
induces
axonal
neurodegeneration
and
motor
nerve
degeneration
by
destroying
oligodendrocytes,
degenerating
white
matter,
inducing
apoptosis,
excitotoxicity,
reducing
myelin
basic
protein
(MBP).
This
study
examines
the
inhibition
of
SIRT-1
(silence
information
regulator
1),
Nrf-2
(nuclear
factor
E2-related
2),
HO-1
(heme
oxygenase
TDP-43
(TAR-DNA-binding
43)
accumulation
in
context
ALS,
as
well
modulation
these
proteins
icariin
(15
30
mg/kg,
orally),
glycoside
flavonoid
with
neuroprotective
properties.
Neuroprotective
activates
SIRT-1,
Nrf-2,
HO-1,
mitigating
inflammation
neuronal
injury
disorders.
In-vivo
in-silico
testing
experimental
ALS
models
confirmed
efficacy
modulating
cellular
targets.
The
addition
sirtinol
10
an
inhibitor
helps
determine
effectiveness
icariin.
In
this
study,
we
also
examined
neurobehavioral,
neurochemical,
histopathological,
LFB
(Luxol
fast
blue)
markers
various
biological
samples,
including
Cerebrospinal
fluid
(CSF),
blood
plasma,
brain
homogenates
(Cerebral
Cortex,
Hippocampus,
Striatum,
mid-brain,
Cerebellum).
These
results
demonstrate
administration
ameliorates
mechanism
underlying
benefits
likely
related
to
regulating
signaling
pathways.
Journal of Geriatric Psychiatry and Neurology,
Год журнала:
2023,
Номер
37(4), С. 318 - 331
Опубликована: Ноя. 29, 2023
A
good
nutritional
status
and
healthy
diets
may
decelerate
disease
disability
symptom
severity
quality
of
life
peoples
with
multiple
sclerosis
(MS).
Mediterranean
diet
(MD)
can
prevent
several
chronic
diseases,
including
neurodegenerative
disease.
This
is
an
observational,
cross-sectional
study
on
279
older
adults
MS,
aiming
to
investigate
the
effects
MD
against
aspects
mental
health.
Qualified
questionnaires
were
used
assess
severity,
depression,
anxiety,
stress,
sleep
quality,
cognitive
status,
physical
activity,
adherence.
Multivariate
analysis
showed
that
enhanced
adherence
was
independently
associated
lower
prevalence
(
P
=
.0019),
depression
.0201),
anxiety
.0287),
perceived
stress
.0021),
inadequate
.0033),
impairment
.0018)
inactivity
.0028).
Adopting
ameliorate
health
disturbances
in
MS.
Future
public
policies
should
inform
MS
for
favorable
impacts
improving
comorbidities.
