Injectable Hydrogels in Cardiovascular Tissue Engineering
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1878 - 1878
Опубликована: Июль 1, 2024
Heart
problems
are
quite
prevalent
worldwide.
Cardiomyocytes
and
stem
cells
two
examples
of
the
supporting
matrix
that
used
in
integrated
process
cardiac
tissue
regeneration.
The
objective
is
to
create
innovative
materials
can
effectively
replace
or
repair
damaged
muscle.
One
most
effective
appealing
3D/4D
scaffolds
for
creating
an
appropriate
milieu
growth
healing
hydrogel.
In
order
successfully
regenerate
heart
tissue,
bioactive
biocompatible
hydrogels
required
preserve
infarcted
region
bid
support
restoration
myocardial
wall
stress,
cell
survival
function.
engineering
uses
a
variety
hydrogels,
such
as
natural
synthetic
polymeric
hydrogels.
This
article
provides
quick
overview
various
hydrogel
types
employed
engineering.
Their
benefits
drawbacks
discussed.
Hydrogel-based
techniques
regeneration
also
addressed,
along
with
their
clinical
application
future
Язык: Английский
The role of glycerol in manufacturing freeze-dried chitosan and cellulose foams for mechanically stable scaffolds in skin tissue engineering
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
275, С. 133602 - 133602
Опубликована: Июль 3, 2024
Various
strategies
have
extensively
explored
enhancing
the
physical
and
biological
properties
of
chitosan
cellulose
scaffolds
for
skin
tissue
engineering.
This
study
presents
a
straightforward
method
involving
addition
glycerol
into
highly
porous
structures
two
polysaccharide
complexes:
chitosan/carboxymethyl
(Chit/CMC)
chitosan/oxidized
(Chit/OC);
during
one-step
freeze-drying
process.
Adding
glycerol,
especially
to
Chit/CMC,
significantly
increased
stability,
prevented
degradation,
improved
mechanical
strength
by
nearly
50%.
Importantly,
after
21
days
incubation
in
enzymatic
medium
Chit/CMC
scaffold
has
almost
completely
decomposed,
while
foams
reinforced
with
exhibited
only
40%
mass
loss.
It
is
possible
due
differences
multivalent
cations
polymer
chain
contraction,
resulting
varied
hydrogen
bonding
and,
consequently,
distinct
physicochemical
outcomes.
Additionally,
cellular
activities
over
higher
proliferation
fibroblast
incubation.
was
achieved
imparting
water
resistance
absorbent
material
aiding
achieving
balance
between
hydrophilic
hydrophobic
properties.
clearly
indicates
elimination
additional
crosslinkers
multiple
fabrication
steps
that
can
reduce
cost
production
engineering
applications
tailoring
degradation.
Язык: Английский
Chitosan/alginate polyelectrolyte complex hydrogels by additive manufacturing for in vitro 3D ovarian Cancer modeling
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 139795 - 139795
Опубликована: Янв. 1, 2025
Язык: Английский
Saponins as Natural Emulsifiers: Challenges, Regulatory Landscape, and Future in Biomedical and Cosmetic Fields
Industrial & Engineering Chemistry Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Язык: Английский
Microfabricated Organ-Specific Models of Tumor Microenvironments
Annual Review of Biomedical Engineering,
Год журнала:
2025,
Номер
27(1), С. 307 - 333
Опубликована: Май 1, 2025
Despite
the
advances
in
detection,
diagnosis,
and
treatments,
cancer
remains
a
lethal
disease,
claiming
lives
of
more
than
600,000
people
United
States
alone
2024.
To
accelerate
development
new
therapeutic
strategies
with
improved
responses,
significant
efforts
have
been
made
to
develop
microfabricated
vitro
models
tumor
microenvironments
(TMEs)
that
address
limitations
animal-based
models.
These
incorporate
several
advanced
tissue
engineering
techniques
better
reflect
organ-
patient-specific
TMEs.
Additionally,
integrated
next-generation
single-cell
omics
technologies
provide
unprecedented
insights
into
patient's
cellular
molecular
heterogeneity
complexity.
This
review
provides
an
overview
recent
understanding
outlines
key
TME
elements
can
be
captured
enhance
their
physiological
relevance.
We
highlight
unique
characteristics
organs
origin
or
sites
dissemination.
Язык: Английский
Affordable, Biodegradable, and Environmentally Friendly Sanitary Napkins for Rural Women, with a Focus on Degradation Study
Results in Engineering,
Год журнала:
2024,
Номер
unknown, С. 102988 - 102988
Опубликована: Сен. 1, 2024
Язык: Английский
Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview
Archives of Plastic Surgery,
Год журнала:
2024,
Номер
51(06), С. 528 - 541
Опубликована: Июль 16, 2024
Abstract
Aging-related
changes
in
the
skin,
such
as
dullness,
dehydration,
and
loss
of
elasticity,
significantly
affect
its
appearance
integrity.
Injectable
“skin
boosters,”
comprising
various
biological
materials,
have
become
increasingly
prominent
addressing
these
issues,
offering
rejuvenation
revitalization.
This
review
offers
a
comprehensive
examination
injectables,
detailing
their
types,
mechanisms
action,
clinical
uses.
It
also
evaluates
evidence
for
effectiveness
safety
treating
age-related
skin
alterations
other
conditions.
The
goal
is
to
provide
an
insightful
understanding
injectable
boosters
contemporary
dermatological
practice,
summarizing
current
state
knowledge.
Язык: Английский
The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffold
Regenerative Therapy,
Год журнала:
2024,
Номер
26, С. 251 - 259
Опубликована: Июнь 1, 2024
Diabetes
Mellitus
(DM)
disrupts
the
body's
capability
to
control
blood
glucose
statuses.
Type
1
diabetes
mellitus
(T1DM)
arises
from
inadequate
insulin
production
and
is
treated
with
replacement
therapy.
Stem
cell
therapy
a
hopeful
treatment
for
T1DM
that
involves
using
adult
stem
cells
generate
insulin-producing
(IPCs).
Mesenchymal
(MSCs)
are
particularly
advantageous
generating
IPCs.
The
islet
require
interactions
extracellular
matrix
survival,
which
lacking
in
conventional
2D
culture
systems.
Natural
or
synthetic
polymers
create
supportive
3D
microenvironment
tissue
engineering.
We
aim
construct
superior
differentiation
conditions
employing
polyethersulfone
(PES)/Fish
gelatin
scaffolds
differentiate
Wharton's
jelly-derived
mesenchymal
(WJ-MSCs)
In
this
study,
PES/fish
scaffold
(3D)
was
manufactured
by
electrospinning,
then
its
biocompatibility
non-toxicity
were
investigated
MTT
assay.
After
that,
scaffold-supportive
effects
on
WJ-MSCs
IPCs
studied
at
gene
protein
levels.
exposure
media,
(PES/Fish
gelatin)
cultured
slowly
aggregated
developed
spherical-shaped
clusters.
viability
of
found
be
comparable
both
cultures.
expression
analysis
showed
efficiency
more
elevated
culture.
Additionally,
ELISA
results
indicated
C-peptide
release
significant
than
conclusion,
highly
promising
pancreatic
engineering
because
it
supports
viability,
growth,
into
Язык: Английский
Development And Formulation Of Drug-Loaded Hydrogel For Skin Regenerative Potential
Journal Of Advanced Zoology,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Skin
injuries,
whether
due
to
trauma,
burns,
or
chronic
wounds,
present
a
significant
clinical
challenge,
highlighting
the
need
for
innovative
regenerative
therapies.
This
study
focuses
on
development
and
formulation
of
drug-loaded
hydrogel
as
promising
approach
skin
regeneration.
Hydrogel
is
designed
provide
supportive
environment
cell
proliferation,
migration,
differentiation,
while
also
delivering
therapeutic
agents
accelerate
wound
healing.
Various
biocompatible
polymers
crosslinking
methods
are
explored
optimize
hydrogel's
mechanical
properties,
biodegradability,
drug
release
kinetics.
Additionally,
investigates
efficacy
different
drugs,
growth
factors,
bioactive
molecules
in
promoting
angiogenesis,
collagen
synthesis,
tissue
remodeling
within
scaffold.
The
developed
holds
great
potential
addressing
wide
range
injuries
advancing
field
dermatology.
In
summary,
hydrogels
represent
avenue
medicine
their
unique
properties
that
support
repair,
delivery,
healing
processes.
Ongoing
research
continues
explore
applications
address
challenges
regeneration
treatment
effectively.
Язык: Английский
Enhanced skin regeneration and therapeutic delivery using novel diamond‐augmented zinc oxide
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Abstract
Background
Recent
advancements
in
dermatological
therapeutics
have
highlighted
the
need
for
treatments
that
enhance
skin
regeneration
and
healing.
Diamond‐Augmented
Zinc
Oxide
(ND‐ZnO)
technology
combines
zinc
oxide
with
diamond
particles
a
unique
core‐shell
structure,
offering
multifaceted
approach
to
overall
health.
Aims
This
study
evaluates
efficacy
of
ND‐ZnO
promoting
human
dermal
fibroblast
migration
growth,
enhancing
total
collagen
synthesis,
improving
transdermal
delivery
active
ingredients
as
daily
comprehensive
topical
therapy.
Patients/Methods
In
vitro
assays
assessed
wound
healing,
production,
absorption.
Human
Dermal
Fibroblasts
(HDFs)
were
used
scratch
assays.
Collagen
synthesis
was
quantified
using
enzyme‐linked
immunosorbent
(ELISA).
Permeation
tests
performed
on
reconstructed
epidermal
tissues
evaluate
niacinamide
Clinical
case
studies
validated
post‐CO
₂
laser
Actinic
Keratosis
removal
recovery.
Results
increased
HDF
by
198%
compared
controls.
showed
71.3%
restoration
production
aged
HDFs.
Skin
permeation
revealed
203%
increase
absorption
ND‐ZnO.
demonstrated
faster
more
effective
healing
post‐ablative
CO₂
significant
improvements
Conclusions
enhances
ingredient
delivery,
substantial
benefits
other
applications.
innovative
holds
promise
advancing
therapeutics,
providing
care
solutions
address
both
protective
regenerative
needs.
Язык: Английский