Enhanced skin regeneration and therapeutic delivery using novel diamond‐augmented zinc oxide DOI Creative Commons
Xinge Zhang,

Claudia Teng,

Xuefei Bai

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Background Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond‐Augmented Zinc Oxide (ND‐ZnO) technology combines zinc oxide with diamond particles a unique core‐shell structure, offering multifaceted approach to overall health. Aims This study evaluates efficacy of ND‐ZnO promoting human dermal fibroblast migration growth, enhancing total collagen synthesis, improving transdermal delivery active ingredients as daily comprehensive topical therapy. Patients/Methods In vitro assays assessed wound healing, production, absorption. Human Dermal Fibroblasts (HDFs) were used scratch assays. Collagen synthesis was quantified using enzyme‐linked immunosorbent (ELISA). Permeation tests performed on reconstructed epidermal tissues evaluate niacinamide Clinical case studies validated post‐CO ₂ laser Actinic Keratosis removal recovery. Results increased HDF by 198% compared controls. showed 71.3% restoration production aged HDFs. Skin permeation revealed 203% increase absorption ND‐ZnO. demonstrated faster more effective healing post‐ablative CO₂ significant improvements Conclusions enhances ingredient delivery, substantial benefits other applications. innovative holds promise advancing therapeutics, providing care solutions address both protective regenerative needs.

Language: Английский

Injectable Hydrogels in Cardiovascular Tissue Engineering DOI Open Access
Raj N. Patel, Dhruvi Patel

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1878 - 1878

Published: July 1, 2024

Heart problems are quite prevalent worldwide. Cardiomyocytes and stem cells two examples of the supporting matrix that used in integrated process cardiac tissue regeneration. The objective is to create innovative materials can effectively replace or repair damaged muscle. One most effective appealing 3D/4D scaffolds for creating an appropriate milieu growth healing hydrogel. In order successfully regenerate heart tissue, bioactive biocompatible hydrogels required preserve infarcted region bid support restoration myocardial wall stress, cell survival function. engineering uses a variety hydrogels, such as natural synthetic polymeric hydrogels. This article provides quick overview various hydrogel types employed engineering. Their benefits drawbacks discussed. Hydrogel-based techniques regeneration also addressed, along with their clinical application future

Language: Английский

Citations

6
The role of glycerol in manufacturing freeze-dried chitosan and cellulose foams for mechanically stable scaffolds in skin tissue engineering DOI Creative Commons

Katarína Verčimáková,

Joanna Karbowniczek, Marian Sedlář

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133602 - 133602

Published: July 3, 2024

Various strategies have extensively explored enhancing the physical and biological properties of chitosan cellulose scaffolds for skin tissue engineering. This study presents a straightforward method involving addition glycerol into highly porous structures two polysaccharide complexes: chitosan/carboxymethyl (Chit/CMC) chitosan/oxidized (Chit/OC); during one-step freeze-drying process. Adding glycerol, especially to Chit/CMC, significantly increased stability, prevented degradation, improved mechanical strength by nearly 50%. Importantly, after 21 days incubation in enzymatic medium Chit/CMC scaffold has almost completely decomposed, while foams reinforced with exhibited only 40% mass loss. It is possible due differences multivalent cations polymer chain contraction, resulting varied hydrogen bonding and, consequently, distinct physicochemical outcomes. Additionally, cellular activities over higher proliferation fibroblast incubation. was achieved imparting water resistance absorbent material aiding achieving balance between hydrophilic hydrophobic properties. clearly indicates elimination additional crosslinkers multiple fabrication steps that can reduce cost production engineering applications tailoring degradation.

Language: Английский

Citations

4
Chitosan/alginate polyelectrolyte complex hydrogels by additive manufacturing for in vitro 3D ovarian Cancer modeling DOI
Simona Braccini, Gianni Pecorini,

Simone Biagini

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139795 - 139795

Published: Jan. 1, 2025

Language: Английский

Citations

0
Saponins as Natural Emulsifiers: Challenges, Regulatory Landscape, and Future in Biomedical and Cosmetic Fields DOI
Eliana Díaz-Cruces,

Thara Tom,

Vicente M. Gómez‐López

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
Microfabricated Organ-Specific Models of Tumor Microenvironments DOI

Jeong Min Oh,

Yongkuk Park, Jungwoo Lee

et al.

Annual Review of Biomedical Engineering, Journal Year: 2025, Volume and Issue: 27(1), P. 307 - 333

Published: May 1, 2025

Despite the advances in detection, diagnosis, and treatments, cancer remains a lethal disease, claiming lives of more than 600,000 people United States alone 2024. To accelerate development new therapeutic strategies with improved responses, significant efforts have been made to develop microfabricated vitro models tumor microenvironments (TMEs) that address limitations animal-based models. These incorporate several advanced tissue engineering techniques better reflect organ- patient-specific TMEs. Additionally, integrated next-generation single-cell omics technologies provide unprecedented insights into patient's cellular molecular heterogeneity complexity. This review provides an overview recent understanding outlines key TME elements can be captured enhance their physiological relevance. We highlight unique characteristics organs origin or sites dissemination.

Language: Английский

Citations

0
Affordable, Biodegradable, and Environmentally Friendly Sanitary Napkins for Rural Women, with a Focus on Degradation Study DOI Creative Commons
Suman Pawar,

Roopa Farshi,

Asha Gowda Karegowda

et al.

Results in Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 102988 - 102988

Published: Sept. 1, 2024

Language: Английский

Citations

3
Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview DOI Creative Commons
Nark‐Kyoung Rho, Hyun Seok Kim, Soo-Young Kim

et al.

Archives of Plastic Surgery, Journal Year: 2024, Volume and Issue: 51(06), P. 528 - 541

Published: July 16, 2024

Abstract Aging-related changes in the skin, such as dullness, dehydration, and loss of elasticity, significantly affect its appearance integrity. Injectable “skin boosters,” comprising various biological materials, have become increasingly prominent addressing these issues, offering rejuvenation revitalization. This review offers a comprehensive examination injectables, detailing their types, mechanisms action, clinical uses. It also evaluates evidence for effectiveness safety treating age-related skin alterations other conditions. The goal is to provide an insightful understanding injectable boosters contemporary dermatological practice, summarizing current state knowledge.

Language: Английский

Citations

3
The generation of islet-like insulin-producing cells from Wharton's jelly-derived mesenchymal stem cells on the PES/fish gelatin scaffold DOI Creative Commons
Fatemeh Soleimanifar,

Nazli Aghapur,

Zeinab Rezaei-Kiasari

et al.

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 251 - 259

Published: June 1, 2024

Diabetes Mellitus (DM) disrupts the body's capability to control blood glucose statuses. Type 1 diabetes mellitus (T1DM) arises from inadequate insulin production and is treated with replacement therapy. Stem cell therapy a hopeful treatment for T1DM that involves using adult stem cells generate insulin-producing (IPCs). Mesenchymal (MSCs) are particularly advantageous generating IPCs. The islet require interactions extracellular matrix survival, which lacking in conventional 2D culture systems. Natural or synthetic polymers create supportive 3D microenvironment tissue engineering. We aim construct superior differentiation conditions employing polyethersulfone (PES)/Fish gelatin scaffolds differentiate Wharton's jelly-derived mesenchymal (WJ-MSCs) In this study, PES/fish scaffold (3D) was manufactured by electrospinning, then its biocompatibility non-toxicity were investigated MTT assay. After that, scaffold-supportive effects on WJ-MSCs IPCs studied at gene protein levels. exposure media, (PES/Fish gelatin) cultured slowly aggregated developed spherical-shaped clusters. viability of found be comparable both cultures. expression analysis showed efficiency more elevated culture. Additionally, ELISA results indicated C-peptide release significant than conclusion, highly promising pancreatic engineering because it supports viability, growth, into

Language: Английский

Citations

1
Development And Formulation Of Drug-Loaded Hydrogel For Skin Regenerative Potential DOI Creative Commons
Sharma T. Sanjay,

T. S. Shanmugarajan

Journal Of Advanced Zoology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Skin injuries, whether due to trauma, burns, or chronic wounds, present a significant clinical challenge, highlighting the need for innovative regenerative therapies. This study focuses on development and formulation of drug-loaded hydrogel as promising approach skin regeneration. Hydrogel is designed provide supportive environment cell proliferation, migration, differentiation, while also delivering therapeutic agents accelerate wound healing. Various biocompatible polymers crosslinking methods are explored optimize hydrogel's mechanical properties, biodegradability, drug release kinetics. Additionally, investigates efficacy different drugs, growth factors, bioactive molecules in promoting angiogenesis, collagen synthesis, tissue remodeling within scaffold. The developed holds great potential addressing wide range injuries advancing field dermatology. In summary, hydrogels represent avenue medicine their unique properties that support repair, delivery, healing processes. Ongoing research continues explore applications address challenges regeneration treatment effectively.

Language: Английский

Citations

0
Enhanced skin regeneration and therapeutic delivery using novel diamond‐augmented zinc oxide DOI Creative Commons
Xinge Zhang,

Claudia Teng,

Xuefei Bai

et al.

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Background Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond‐Augmented Zinc Oxide (ND‐ZnO) technology combines zinc oxide with diamond particles a unique core‐shell structure, offering multifaceted approach to overall health. Aims This study evaluates efficacy of ND‐ZnO promoting human dermal fibroblast migration growth, enhancing total collagen synthesis, improving transdermal delivery active ingredients as daily comprehensive topical therapy. Patients/Methods In vitro assays assessed wound healing, production, absorption. Human Dermal Fibroblasts (HDFs) were used scratch assays. Collagen synthesis was quantified using enzyme‐linked immunosorbent (ELISA). Permeation tests performed on reconstructed epidermal tissues evaluate niacinamide Clinical case studies validated post‐CO ₂ laser Actinic Keratosis removal recovery. Results increased HDF by 198% compared controls. showed 71.3% restoration production aged HDFs. Skin permeation revealed 203% increase absorption ND‐ZnO. demonstrated faster more effective healing post‐ablative CO₂ significant improvements Conclusions enhances ingredient delivery, substantial benefits other applications. innovative holds promise advancing therapeutics, providing care solutions address both protective regenerative needs.

Language: Английский

Citations

0