Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System DOI Creative Commons
Hui Li,

Jun-Wei Liu,

Jingru Wang

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 372 - 372

Published: Dec. 9, 2024

CY1-4, 9-nitropyridine [2',3':4,5] pyrimido [1,2-α] indole -5,11- dione, is an indoleamine 2,3-dioxygenase (IDO) inhibitor and a poorly water-soluble substance. It very important to increase the solubility of CY1-4 improve its bioavailability therapeutic effect. In this study, mesoporous silica nano-skeleton carrier material Sylysia was selected as load then drug delivery system (MSNM@CY1-4) prepared by coating hydrophilic polymer Hydroxypropyl methylcellulose (HPMC) lipid Distearoylphosphatidyl-ethanolamine-poly(ethylene glycol)

Language: Английский

Advancements in zinc oxide nanomaterials: Synthesis, properties, and diverse applications DOI
Hussain Gulab,

Nusrat Fatima,

Urooj Tariq

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101271 - 101271

Published: July 24, 2024

Language: Английский

Citations

19
Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery DOI

Fanjia Dai,

Fengjiao Chen, Jiaying Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7289 - 7299

Published: March 28, 2024

The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer delivery release in tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed doxorubicin (DOX). profile suggested sustained micelles an accelerated at lower pH higher ROS levels. cellular uptake assay indicated that were internalized by HepG2 cells enhanced folate modification through receptor-mediated endocytosis pathway. Furthermore, nanocarriers demonstrated inhibition migration scratch test showed improved suppression proliferation IC50 than nonfolate viability test, indicating desirable vitro efficiency nanosystem.

Language: Английский

Citations

9
Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity DOI Creative Commons
Jingru Wang,

Man Liu,

Jingwen Wang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(10), P. 4493 - 4508

Published: July 6, 2024

We prepared biocompatible and environment-friendly zinc oxide nanoparticles (ZnO NPs) with upconversion properties catalase-like nanozyme activity. Photodynamic therapy (PDT) application is severely limited by the poor penetration of UV-Visible light a hypoxic tumor environment. Here, we used ZnO NPs as carrier for photosensitizer chlorin e6 (Ce6) to construct oxide-chlorin (ZnO-Ce6 NPs), simultaneously addressing both problems. In terms penetration, convert 808 nm near-infrared into 401 visible excite Ce6, achieving deep-penetrating photodynamic under long-wavelength light. Interestingly, ability emit short-wavelength usually observed in nanoparticles. As nanozymes, can catalyze decomposition hydrogen peroxide tumors, providing oxygen action relieving hypoxia. The enhanced produces large amount reactive species, which overactivate autophagy trigger immunogenic cell death (ICD), leading antitumor immunotherapy. addition, even absence light, ZnO-Ce6 induce ferroptosis cells exert effects.

Language: Английский

Citations

7
Self-Assembled Nanocomposite DOX/TPOR4@CB[7]4 for Enhanced Synergistic Photodynamic Therapy and Chemotherapy in Neuroblastoma DOI Creative Commons

Zhouxia Lu,

Xu Chen, Conghui Wang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 822 - 822

Published: June 18, 2024

DOX/TPOR4@CB[7]4 was synthesized via self-assembly, and its physicochemical properties ability to generate reactive oxygen species (ROS) were evaluated. The impact of photodynamic therapy on SH-SY5Y cells assessed using the MTT assay, while flow cytometry analysis employed detect cell apoptosis. Confocal laser scanning microscopy utilized observe intracellular distribution in cells. Additionally, fluorescence imaging nude mice bearing tumors examination combined effects chemical therapies conducted. incorporation CB[7] significantly enhanced optical DOX/TPOR4@CB[7]4, resulting increased ROS production pronounced toxicity towards Moreover, both apoptotic mortality rates exhibited significant elevation. In vivo experiments demonstrated that tumor growth inhibition most prominent group. π–π interactions facilitated binding between DOX photosensitizer TPOR, with TPOR’s naphthalene hydrophilic groups encapsulated within CB[7]’s cavity through host–guest CB[7]. Therefore, can serve as a nanocarrier enhance application therapy, thereby improving treatment efficacy against neuroblastoma tumors.

Language: Английский

Citations

1
Micro-Surgeons and Nano-Pharmacists: The Future of Healthcare with Medical Nanorobots DOI

Sanaz Aliakbarzadeh,

Majid Abdouss, Sonia Fathi‐karkan

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106410 - 106410

Published: Nov. 1, 2024

Language: Английский

Citations

0
Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System DOI Creative Commons
Hui Li,

Jun-Wei Liu,

Jingru Wang

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 372 - 372

Published: Dec. 9, 2024

CY1-4, 9-nitropyridine [2',3':4,5] pyrimido [1,2-α] indole -5,11- dione, is an indoleamine 2,3-dioxygenase (IDO) inhibitor and a poorly water-soluble substance. It very important to increase the solubility of CY1-4 improve its bioavailability therapeutic effect. In this study, mesoporous silica nano-skeleton carrier material Sylysia was selected as load then drug delivery system (MSNM@CY1-4) prepared by coating hydrophilic polymer Hydroxypropyl methylcellulose (HPMC) lipid Distearoylphosphatidyl-ethanolamine-poly(ethylene glycol)

Language: Английский

Citations

0