Antimicrobial Peptides: An Update on Classifications and Databases

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11691 - 11691

Опубликована: Окт. 28, 2021

Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and an indispensable component host defenses. They consist predominantly short cationic with a wide variety structures targets. Given the ever-emerging resistance various pathogens to existing antimicrobial therapies, AMPs have recently attracted extensive interest as potential therapeutic agents. As discovery new has increased, many databases specializing in been developed collect both fundamental pharmacological information. In this review, we summarize sources, structures, modes action, classifications AMPs. Additionally, examine current AMP databases, compare valuable computational tools used predict activity mechanisms highlight machine learning approaches that can be employed improve combat global resistance.

Язык: Английский

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EAACIMolecular Allergology User's Guide 2.0

Pediatric Allergy and Immunology, Год журнала: 2023, Номер 34(S28)

Опубликована: Март 1, 2023

Abstract Since the discovery of immunoglobulin E (IgE) as a mediator allergic diseases in 1967, our knowledge about immunological mechanisms IgE‐mediated allergies has remarkably increased. In addition to understanding immune response and clinical symptoms, allergy diagnosis management depend strongly on precise identification elicitors reaction. past four decades, innovations bioscience technology have facilitated production well‐defined, highly pure molecules for component‐resolved (CRD), allowing personalized disease individual patients. The first edition “EAACI Molecular Allergology User's Guide” (MAUG) 2016 rapidly became key reference clinicians, scientists, interested readers with background allergology, immunology, biology, medicine. Nevertheless, field molecular allergology is moving fast, after 6 years, new EAACI Taskforce was established provide an updated document. Guide 2.0 summarizes state‐of‐the‐art information allergen molecules, their relevance, application diagnostic algorithms practice. It designed both, clinicians guiding health care professionals through overwhelming list different available testing. Further, it provides relevance allergenic gives overview basic test formats, tests measure exposure.

Язык: Английский

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Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health

Biosafety and Health, Год журнала: 2022, Номер 4(2), С. 118 - 134

Опубликована: Фев. 26, 2022

Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their broad-spectrum resistance to bacteria, fungi, viruses and parasites, influencing host immune responses. AMPs attributed good biological effects have been used in various areas of human health, which trying completely replace antibiotics, owing serious drug-resistance bacteria. However, limited bioactivity potential biotoxicity some was neglected, attributable hydrophobic structure with positive charges nonspecific destruction cell membranes. Various strategies design biosynthetic optimized improve bioactivity, productivity, while lowering toxicity cost. Here, we focus on progress made understanding AMPs, including biosynthesis (AMP-BioDesign 1.0 2.0), (e.g. regulation or actions against parasites), principle hemolysis, acute instability, ect). The application prospects AMP clinical medicine (for novel drugs), tissue engineering drug delivery system, respectively, summarized this review. Furthermore, future new strategy development effective low-toxic formulations health discussed.

Язык: Английский

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Diversity and Mechanisms of Action of Plant, Animal, and Human Antimicrobial Peptides

Antibiotics, Год журнала: 2024, Номер 13(3), С. 202 - 202

Опубликована: Фев. 21, 2024

Antimicrobial peptides (AMPs) are usually made up of fewer than 100 amino acid residues. They found in many living organisms and an important factor those organisms’ innate immune systems. AMPs can be extracted from various sources, including bacteria, plants, animals, even humans. cationic with amphiphilic structure, which allows them to easily bind interact the cellular membranes viruses, fungi, other pathogens. act against both Gram-negative Gram-positive pathogens have modes action them. Some attack pathogens’ membranes, while others target their intracellular organelles, as well nucleic acids, proteins, metabolic pathways. A crucial area AMP use is related ability help emerging antibiotic resistance: some active resistant strains susceptible peptide engineering. This review considers three key sources—plants, humans—as sequences.

Язык: Английский

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Plant antimicrobial peptides: An overview about classification, toxicity and clinical applications

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 214, С. 10 - 21

Опубликована: Июнь 11, 2022

Язык: Английский

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An Overview of the Potentialities of Antimicrobial Peptides Derived from Natural Sources

Antibiotics, Год журнала: 2022, Номер 11(11), С. 1483 - 1483

Опубликована: Окт. 26, 2022

Antimicrobial peptides (AMPs) are constituents of the innate immune system in every kind living organism. They can act by disrupting microbial membrane or without affecting stability. Interest these small stems from fear antibiotics and emergence microorganisms resistant to antibiotics. Through metabolic disruption, they defend an organism against invading bacteria, viruses, protozoa, fungi. High efficacy specificity, low drug interaction toxicity, thermostability, solubility water, biological diversity suggest their applications food, medicine, agriculture, animal husbandry, aquaculture. Nanocarriers be used protect, deliver, improve bioavailability effectiveness. cost production could limit use. This review summarizes natural sources, structures, modes action, food pharmaceutical industries. Any restrictions on AMPs’ large-scale also taken into consideration.

Язык: Английский

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GASA Proteins: Review of Their Functions in Plant Environmental Stress Tolerance

Plants, Год журнала: 2023, Номер 12(10), С. 2045 - 2045

Опубликована: Май 21, 2023

Gibberellic acid-stimulated Arabidopsis (GASA) gene family is a class of functional cysteine-rich proteins characterized by an N-terminal signal peptide and C-terminal-conserved GASA domain with 12 invariant cysteine (Cys) residues. are widely distributed among plant species, the majority them involved in transmission hormones, regulation development growth, responses to different environmental constraints. To date, their action mechanisms not completely elucidated. This review reports overview diversity, structure, subcellular localization proteins, involvement hormone crosstalk redox during development, abiotic biotic stresses. Knowledge this complex can be contribution promoting multiple stress tolerance potential agricultural applications through engineering genes encoding production transgenic plants.

Язык: Английский

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Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications

ACS Infectious Diseases, Год журнала: 2024, Номер 10(4), С. 1034 - 1055

Опубликована: Март 1, 2024

Pathogenic bacteria cause the deaths of millions people every year. With development antibiotics, hundreds and thousands people's lives have been saved. Nevertheless, can develop resistance to rendering them insensitive antibiotics over time. Peptides containing specific amino acids be used as antibacterial agents; however, they easily degraded by proteases in vivo. To address these issues, branched peptide dendrimers are now being considered good agents due their high efficacy, protease degradation, low cytotoxicity. The ease with which synthesized modified makes accessible for use various biological nonbiological fields. That is, hold a promising future prolonged efficacy without bacterial development. Their vivo stability multivalence allow effectively target multi-drug-resistant strains prevent biofilm formation. Thus, it is interesting an overview applications research, including possibility employing machine learning approaches design AMPs dendrimers. This review summarizes synthesis agents. challenges perspectives using also discussed.

Язык: Английский

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Plant-Derived Antimicrobial Peptides: Novel Preservatives for the Food Industry

Foods, Год журнала: 2022, Номер 11(16), С. 2415 - 2415

Опубликована: Авг. 11, 2022

Food spoilage is a widespread issue brought on by the undesired growth of microbes in food products. Thousands tons usable or products are wasted every day due to rotting different parts world. Several preservation techniques employed prevent from rotting, including use natural manufactured chemicals substances; however, persists. One strategy for halting deterioration plant-derived antimicrobial peptides (AMPs), which have been investigated possible bioactivities against range human, plant, and pathogens. The industry may be able benefit development synthetic AMPs, produced plants that higher bioactivity, better stability, decreased cytotoxicity as means preservation. In order exploit AMPs various techniques, this review, we also outline difficulties developing commercial preservatives. Nevertheless, technology advances, it will soon fully explore promise

Язык: Английский

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Pepsin: An Excellent Proteolytic Enzyme for the Production of Bioactive Peptides

Food Reviews International, Год журнала: 2023, Номер 40(7), С. 1875 - 1912

Опубликована: Авг. 1, 2023

ABSTRACTThe production of bioactive peptides (BPs) usually involves the enzymatic hydrolysis stage during which one or more proteases are used to break down parental protein into shorter fragments. In this review, efforts were made focus on using pepsin as a unique protease capable generating BPs. We started with description BPs and prior unraveling pepsin's properties immobilization for The peptic food-derived proteins generate biological functions, e.g. antioxidative, ACE-inhibitory, metal-binding, antidiabetic, anti-inflammatory, antimicrobial activities from vegetable, fish, seafood, whey, casein, blood plasma, egg proteins, among other unconventional sources discussed. review concluded in developing food products their techno-functional such emulsifying, water, fat-holding capacities.KEYWORDS: Proteasepepsinbioactive peptidesbioactivitytechno-functional propertiesnutrition AcknowledgmentsThe first author expresses special thanks Duy Tan University, National Foundation Science Technology Development (NAFOSTED) Vietnam supporting research. last acknowledges Chinese Ministry "the Belt Road" Innovative Talent Exchange Foreign Expert Project (Grant Number DL2021003001 DL2021014003L).Disclosure statementNo potential conflict interest was reported by author(s).Author contributionsConceptualization: TJA. Writing: TJA, CCL, JOA, OT, HP. Revision: TJA SMJ. Final draft: SMJ.Additional informationFundingThe work supported People's Republic China [DL2021003001 DL2021014003L].

Язык: Английский

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