JURNAL ILMU KEDOKTERAN DAN KESEHATAN,
Год журнала:
2023,
Номер
9(10), С. 2825 - 2832
Опубликована: Окт. 10, 2023
Abstrak:
Kajian
Pustaka:
Tanda
Dan
Proses
Penuaan
Pada
Mata.
Dengan
bertambahnya
usia
sampai
dengan
dewasa,
seluruh
komponen
tubuh
tidak
lagi
dapat
berkembang,
tetapi
sebaliknya
akan
terjadi
penurunan
bahkan
terhentinya
fungsi
berbagai
organ
karena
proses
penuaan.
yang
di
dalam
berjalan
secara
mendadak,
perlahan
seiring
pertambahan
usia.
pada
mata
melibatkan
banyak
struktur
oragan
dan
sel
menimbulkan
gejala
gangguan
menggangu
baik
fungsi,
anatomis
maupun
estetika.
memahami
terjadinya
penuaan
diharapkan
mencegah,
mengambat
memperlambat
tersebut.
Current Opinion in Ophthalmology,
Год журнала:
2023,
Номер
35(1), С. 57 - 63
Опубликована: Окт. 26, 2023
Purpose
of
review
Oxidative
stress
plays
a
central
role
in
cataract
pathogenesis,
leading
cause
global
blindness.
This
delves
into
the
oxidative
development
and
key
biomarkers
–
glutathione
(GSH),
superoxide
dismutase
(SOD),
malondialdehyde
(MDA),
4-hydroxynonenal
(4-HNE)
to
clarify
their
functions
potential
applications
predictive
diagnostics
therapies.
Recent
findings
Antioxidants
serve
as
pivotal
markers
pathogenesis.
GSH
affects
lens
due
factors
such
enzyme
depletion
altered
connexin
expression,
impairing
diffusion.
Age-related
may
hinder
transport
via
channels
or
an
internal
microcirculation
system.
N-acetylcysteine,
precursor,
shows
promise
mitigating
opacity
when
applied
topically.
Additionally,
SOD,
particularly
SOD1,
correlates
with
increased
gel
formulations
have
exhibited
protective
effects
against
posterior
subscapular
cataracts.
Lastly,
lipid
peroxidation,
MDA
4-HNE,
been
shown
reflect
disease
severity.
Studies
suggest
link
between
4-HNE
channel
modification,
possibly
contributing
reduced
levels.
Summary
is
significant
contributor
development,
underscoring
importance
antioxidants
diagnosis
treatment.
Notably,
depletion,
SOD
decline,
peroxidation
are
offering
promising
avenues
for
both
therapeutic
intervention.
Nutrients,
Год журнала:
2023,
Номер
15(10), С. 2283 - 2283
Опубликована: Май 12, 2023
This
review
aims
to
discuss
the
delicate
balance
between
physiological
production
of
reactive
oxygen
species
and
role
antioxidant
nutraceutical
molecules
in
managing
radicals
complex
anatomical
structure
eye.
Many
enzymes
with
reducing
potential
are
present
different
parts
Some
these,
such
as
glutathione,
N-acetylcysteine,
α-lipoic
acid,
coenzyme
Q10,
enzymatic
antioxidants,
endogenously
produced
by
body.
Others,
plant-derived
polyphenols
carotenoids,
vitamins
B2,
C,
E,
zinc
selenium,
omega-3
polyunsaturated
fatty
acids,
must
be
obtained
through
diet
considered
essential
nutrients.
When
equilibrium
their
scavenging
is
disrupted,
radical
generation
overwhelms
endogenous
arsenal,
leading
oxidative
stress-related
eye
disorders
aging.
Therefore,
roles
antioxidants
contained
dietary
supplements
preventing
stress-based
ocular
dysfunctions
also
discussed.
However,
results
studies
investigating
efficacy
supplementation
have
been
mixed
or
inconclusive,
indicating
a
need
for
future
research
highlight
develop
new
preventive
nutritional
strategies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3609 - 3609
Опубликована: Март 23, 2024
The
retinal
pigment
epithelium
(RPE),
which
ensures
the
normal
functioning
of
neural
retina,
is
a
pigmented
single-cell
layer
that
separates
retina
from
Bruch's
membrane
and
choroid.
There
are
three
main
types
granules
in
RPE
cells
human
eye:
lipofuscin
(LG)
containing
fluorescent
"age
pigment"
lipofuscin,
melanoprotein
(melanosomes,
melanolysosomes)
screening
melanin
complex
melanolipofuscin
(MLG)
both
pigments
simultaneously-melanin
lipofuscin.
This
review
examines
functional
role
aging
process
development
oxidative
stress
associated
pathologies
cells.
focus
on
light-induced
degradation
caused
by
reactive
oxygen
species.
reasons
leading
to
increased
as
result
considered.
A
mechanism
proposed
explain
phenomenon
age-related
decline
content
essence
when
part
granule
exposed
light,
species
formed,
destroy
part.
As
more
formed
with
age
degenerative
diseases,
epithelial
ultimately
disappears.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2042 - 2042
Опубликована: Март 17, 2025
Background/Objectives:
Glaucoma,
a
leading
cause
of
irreversible
blindness,
has
been
associated
with
systemic
and
ocular
aging
processes.
This
study
aimed
to
investigate
the
relationship
between
glaucoma
accelerated
biological
using
fundus-derived
age
prediction.
Additionally,
role
factors
retinal
vascular
changes
in
this
association
was
explored.
Methods:
A
total
6023
participants,
including
547
patients
matched
controls,
were
analyzed.
Fundus-derived
predicted
assessed
deep
learning
model
(EfficientNet).
Systemic
such
as
BMI,
blood
pressure,
lipid
profiles,
liver
function
markers,
glucose
levels,
(Scheie
classifications)
Statistical
comparisons
multivariate
regression
analyses
performed
evaluate
impact
on
acceleration,
adjusting
for
age,
gender,
factors.
Results:
Glaucoma
significantly
higher
acceleration
(prediction
difference:
−1.5
±
4.5
vs.
−2.1
years;
p
=
0.040).
Multivariate
confirmed
that
independently
influenced
(p
0.021)
prediction
difference
0.021).
Among
factors,
γ-GTP
positively
0.036),
while
other
showed
no
significant
association.
Retinal
changes,
hypertensive
sclerotic
classifications),
more
prevalent
correlated
acceleration.
Conclusions:
is
aging,
indicated
by
age.
may
play
contributory
roles.
holds
promise
non-invasive
biomarker
monitoring
aging.
Further
longitudinal
studies
are
warranted
establish
causal
relationships
enhance
clinical
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13053 - 13053
Опубликована: Дек. 4, 2024
Age-related
macular
degeneration
(AMD)
is
the
most
common
cause
of
irreversible
loss
central
vision
in
elderly
subjects,
affecting
men
and
women
equally.
It
a
degenerative
pathology
that
causes
progressive
damage
to
macula,
vital
part
retina.
There
are
two
forms
AMD
depending
on
how
macula
damaged,
dry
wet
or
neovascular
AMD.
Dry
form;
waste
materials
accumulate
under
retina
as
old
cells
die,
not
being
replaced.
Wet
less
common,
but
can
lead
much
more
quickly.
characterized
by
new
abnormal
blood
vessels
developing
where
they
do
normally
grow.
This
frequently
occurs
patients
who
already
have
AMD,
developed
try
solve
problem.
known
what
develop;
however,
certain
risk
factors
(i.e.,
age,
smoking,
genetic
factors)
increase
currently
no
treatments
for
evidence
exercising
regularly,
eating
nutritious
food,
taking
supplements
reduce
acquiring
slow
its
development.
The
main
treatment
inhibitors
VEGF
(vascular
endothelial
growth
factor),
protein
stimulates
vessels.
stop
vessels,
preventing
further
loss.
In
patients,
improve
if
diagnosed
early
treated
accordingly.
However,
cannot
repair
has
occurred.
Current
research
trying
find
other
options
review
provides
summary
current
regarding
different
aimed
at
both
with
particular
greater
attention
form.
The
retinal
pigment
epithelium
(RPE),
which
ensures
the
normal
functioning
of
neural
retina,
is
a
pigmented
single-cell
layer
that
separates
retina
from
Bruch's
membrane
and
choroid.
There
are
three
main
types
granules
in
RPE
cells
human
eye:
lipofuscin
(LG)
containing
fluorescent
“age
pigment”
lipofuscin,
melanoprotein
(melanosomes,
melanolysosomes)
screening
melanin
complex
melanolipofuscin
(MLG)
simultaneously
both
pigments
-
lipofuscin.
This
review
examines
functional
role
aging
process
development
oxidative
stress
associated
pathologies
cells.
focus
on
light-induced
degradation
caused
by
reactive
oxygen
species.
reasons
leading
to
increased
as
result
considered.
A
mechanism
has
been
proposed
explain
phenomenon
age-related
decline
content
essence
when
part
granule
exposed
light,
species
formed,
destroy
its
part.
As
more
formed
with
age
degenerative
diseases,
epithelial
ultimately
disappears.
