Siberian Herald of Agricultural Science,
Год журнала:
2023,
Номер
53(11), С. 71 - 85
Опубликована: Дек. 18, 2023
Molecular
engineering
is
an
upstream
method
for
creating
functional
materials
and
devices
using
molecules,
atoms
as
building
blocks.
In
2000,
Japan
became
the
first
country
to
genetically
modify
silkworms
(
Bombyx
mori
,
hereinafter
referred
B.
).
The
subsequent
research
in
development
of
new
expanded
possibilities
sericulture
products,
characterizing
this
situation
a
"sericulture
revolution".
Russian
Federation,
molecular
life
sciences
aimed
at
solving
tasks
developing
world-class
technological
platforms
create
tools
produce
molecules
(biopolymers,
proteins,
enzymes),
bioproducts,
cells
organisms.
main
"bottom-up"
approaches
applied
process
(USP)
stage
silk
production
improve
economic
performance
quality
characteristics
raw
have
been
studied.
variety
improvement
methods
includes:
possibility
artificial
nutrient
medium,
based
on
transient
expression
techniques
or
stable
germline
transformation,
genetic
selection
methods,
breeding
management,
etc.
advantages
mulberry
silkworm
)
such
low
costs,
significantly
higher
yield
compared
other
protein
systems,
favor
its
use
effective
producer
recombinant
antimicrobial
peptides
biologically
active
substances.
USP
biotechnologies
enable
downstream
processing
(DSP)
wide
range
products
that
contribute
improving
human
life.
A
set
biotechnological
solutions
forms
modern
basis
bioindustrial
platform.
To
safeguard
against
microbial
diseases
and
maintain
optimal
silk
yields,
the
sericulture
industry
relies
on
antibiotics
to
promote
health,
well-being,
vitality
of
silkworms
(Bombyx
mori).
Antibiotics
are
commonly
incorporated
into
synthetic
diets
for
rearing
or
included
as
key
components
in
bed
disinfectant
formulations.
The
silkworm-rearing
industry’s
reliance
has
led
concerns
about
development
antibiotic-resistant
bacteria.
Previous
research
uncovered
a
dual
role
antibiotics:
not
only
do
they
prevent
disease,
but
also
silkworm
growth
by
reshaping
gut
microbiome
enhancing
nutrient
absorption,
highlighting
need
judicious
use.
Therefore,
there
is
critical
prudent
management
further
exploration
alternative
growth-promoting
strategies
minimize
resistance
risks.
This
study
investigates
relationship
between
antibiotic
administration
growth,
shedding
light
mechanisms
underlying
antibiotic-induced
effects
assessing
risk
antimicrobial
(AMR)
emergence
dissemination.
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3318 - 3318
Опубликована: Июль 15, 2024
The
nutrients
present
in
food
are
not
only
prone
to
a
series
of
physicochemical
reactions
but
also
provide
conditions
for
the
growth
and
reproduction
foodborne
microorganisms.
In
recent
years,
many
innovative
methods
from
different
fields
have
been
introduced
into
preservation,
which
extends
shelf
life
while
maximizing
preservation
original
ingredients
properties
food.
this
field,
there
is
lack
systematic
summary
new
technologies
emerging.
view
this,
we
overview
applied
field
3
focusing
on
variety
technological
approaches
such
as
antimicrobial
photodynamic
therapy
based
nanotechnology,
electromagnetic
radiation
sterilization
technology,
peptides
biomolecules.
We
discuss
mechanism
application
specific
categories
products.
evaluated
their
advantages
limitations
industry,
describing
development
prospects.
addition,
microorganisms
main
causes
spoilage,
our
review
has
reference
significance
clinical
antibacterial
treatment.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 23, 2024
Insects
are
established
models
for
understanding
host-pathogen
interactions
and
innate
immune
mechanisms.
The
system
in
insects
is
highly
efficient
recognizing
opposing
pathogens
that
cause
detrimental
effects
during
infection.
cuticular
layer
which
covers
the
superficial
of
insect
body
participates
host
defense
wound
healing
by
inducing
responses.
Previous
studies
have
started
to
address
involvement
genes
conferring
resistance
pathogens,
particularly
those
infect
disrupting
cuticle.
For
example,
gene
Transglutaminase
(TG)
Drosophila
melanogaster
plays
a
structural
role
cuticle
formation
blood
coagulation
also
possesses
properties
against
pathogenic
However,
more
information
becoming
available
about
function
other
families
insects.
In
this
review,
we
aim
highlight
recent
advances
immunity
necessity
pursuing
further
research
fill
existing
gaps
important
field
immunology.
This
will
lead
novel
strategies
management
agricultural
pests
vectors
plant
human
disease.
Entomological Research,
Год журнала:
2024,
Номер
54(3)
Опубликована: Фев. 29, 2024
Abstract
Innate
immunity
is
the
immediate
and
exclusive
defense
mechanism
in
invertebrates.
It
acts
against
foreign
agents
pathogens.
In
insects,
this
involves
a
combination
of
humoral
cellular
responses,
orchestrated
by
specific
recognition
receptors
activation
various
signaling
pathways.
Remarkably,
Toll
Toll‐related
proteins
play
pivotal
role
insect
inducing
production
antimicrobial
peptides
(AMPs)
response
to
pathogen
attacks.
receptors,
which
are
type
I
transmembrane
proteins,
significantly
affect
development
innate
immune
response,
primarily
via
nuclear
factor
kappa‐B
pathway.
The
Malpighian
tubules
insects
crucial
waste
elimination,
hemostasis
maintenance,
defense.
pathway
mainly
involved
AMPs.
This
review
provides
valuable
insights
into
mechanisms
morphological
physiological
attributes
tubules.
Moreover,
it
discusses
classification
functionalities
AMPs
synthesized
pathogens,
thereby
contributing
our
understanding
insects.
Archives of Insect Biochemistry and Physiology,
Год журнала:
2024,
Номер
116(3)
Опубликована: Июль 1, 2024
Abstract
Ubiquitin‐fold
modifier
1
(UFM1)
is
attached
to
protein
substrates
through
the
sequential
activity
of
an
E1
(UBA5)‐E2
(UFC1)‐E3
(UFL1)
cascade.
UFL1
E3
ligase
for
UFMylation
in
vertebrates.
However,
there
have
been
no
studies
on
silkworm
date.
In
this
study,
we
identified
a
ortholog
Bombyx
mori
genome.
Spatio‐temporal
expression
profiles
showed
that
BmUFL1
was
high
midgut,
epidermis,
and
testis
pupa–adult
stage.
knockdown
inhibited
B.
nucleopolyhedrovirus
(BmNPV)
proliferation,
while
overexpression
promoted
BmNPV
proliferation.
Mechanically,
kinase
RNA‐like
endoplasmic
reticulum
(PERK)
signaling
cell
apoptosis
are
involved
BmUFL1‐regulated
Overall,
these
results
suggest
facilitates
proliferation
silkworm.
Annals of Animal Science,
Год журнала:
2023,
Номер
24(1), С. 77 - 88
Опубликована: Июль 12, 2023
Abstract
Antimicrobial
peptides
(AMPs)
are
the
focus
of
this
manuscript,
as
bioconservative
molecules
that
constitute
a
major
defense
mechanism
in
many
organisms.
Various
antimicrobial
have
been
isolated
and
identified,
but
AMPs
derived
from
Hermetia
illucens
(HI)
will
be
review.
The
review
focuses
mainly
on
cecropins,
defensins,
attacins.
is
remarkable
organism
adapted
to
life
diverse,
often
highly
polluted
environment,
its
resilience
largely
attributed
amps.
Amps
active
against
bacterial
fungal
species
also
act
induce
osmotic
lysis
protozoa.
They
attack
pathogenic
microorganisms
without
damaging
host
cells
process.
Given
increasing
antibiotic
resistance
strains
animal
production,
amps
appear
tempting
alternative
substances
limit
inhibit
growth
development
pathogens,
well
an
option
veterinary
medicine
potential
substitutes
for
antibiotics,
administration
which
must
limited
european
union.
amp
content
HI
larvae
extracts,
determines
their
activity,
depends
larval
diet
solvent
used.
This
presents
vitro
studies
effects
vivo
Hi
meal
feed
supplement.
