Tannic acid: a versatile polyphenol for design of biomedical hydrogels

Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(31), С. 5873 - 5912

Опубликована: Янв. 1, 2022

Tannic acid (TA), a natural polyphenol, is hydrolysable amphiphilic tannin derivative of gallic with several galloyl groups in its structure. interacts various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins polysaccharides via hydrogen bonding, electrostatic, coordinative interactions. has been studied for biomedical applications crosslinker anti-inflammatory, antibacterial, anticancer activities. In this review, we focus on TA-based hydrogels biomaterials engineering to help scientists engineers better realize TA's potential the design fabrication novel hydrogel biomaterials. The interactions TA or synthetic compounds are deliberated, discussing parameters that affect TA-material thus providing fundamental set criteria utilizing tissue healing regeneration. review also discusses merits demerits using developing either through direct incorporation formulation indirectly immersing final product solution. general, bioactive molecule diverse hydrogels.

Язык: Английский

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Biomedical applications of tannic acid

Journal of Biomaterials Applications, Год журнала: 2022, Номер 36(8), С. 1503 - 1523

Опубликована: Янв. 7, 2022

Tannic Acid (TA) is a naturally occurring antioxidant polyphenol that has gained popularity over the past decade in field of biomedical research for its unique biochemical properties. acid, typically extracted from oak tree galls, been used many important historical applications. TA key component vegetable tanning leather, iron gall ink, red wines, and as traditional medicine to treat variety maladies. The basis utility derived hydroxyl groups affinity forming hydrogen bonds with proteins other biomolecules. Today, study led development new pharmaceutical shown reduce inflammation an antioxidant, act antibiotic common pathogenic bacterium, induce apoptosis several cancer types. also displayed antiviral antifungal activity. At certain concentrations, can be gastrointestinal disorders such hemorrhoids diarrhea, severe burns, protect against neurodegenerative diseases. utilized biomaterials natural crosslinking agent improve mechanical properties synthetic hydrogels polymers, while imparting anti-inflammatory, antibacterial, anticancer activity materials. develop thin film coatings nanoparticles drug delivery. In all, fascinating molecule wide potential uses pharmaceuticals, applications, delivery strategies.

Язык: Английский

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A hydrogen-bonded antibacterial curdlan-tannic acid hydrogel with an antioxidant and hemostatic function for wound healing

Carbohydrate Polymers, Год журнала: 2022, Номер 285, С. 119235 - 119235

Опубликована: Фев. 10, 2022

Язык: Английский

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Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

Bioactive Materials, Год журнала: 2022, Номер 20, С. 93 - 110

Опубликована: Май 21, 2022

The revolutionary role of tissue adhesives in wound closure, sealing, and bleeding control necessitates the development multifunctional materials capable effective scarless healing. In contrast to use traditionally utilized toxic oxidative crosslinking initiators (exemplified by sodium periodate silver nitrate), herein, natural polyphenolic compound tannic acid (TA) was used achieve near instantaneous (<25s), hydrogen bond mediated gelation citrate-based mussel-inspired bioadhesives combining anti-oxidant, anti-inflammatory, antimicrobial activities (3A-TCMBAs). resulting were self-healing possessed low swelling ratios (<60%) as well considerable mechanical strength (up ∼1.0 MPa), elasticity (elongation ∼2700%), adhesion 40 kPa). 3A-TCMBAs showed strong vitro vivo anti-oxidant ability, favorable cytocompatibility cell migration, photothermal activity against both Staphylococcus aureus Escherichia coli (>90% bacterial death upon near-infrared (NIR) irradiation). evaluation an infected full-thickness skin model a rat incision demonstrated that + NIR treatment could promote closure collagen deposition improve I/III ratio on sites while simultaneously inhibiting expression pro-inflammatory cytokines. Further, phased angiogenesis observed via promotion early phases followed inhibition triggering degradation & remodeling extracellular matrix (ECM) late stage (supported CD31 (platelet endothelial molecule-1) PDGF (platelet-derived growth factor) VEGF (vascular elevated metalloprotein-9 (MMP-9) day 21), significant convergence material bioactive properties elucidated above warrant further exploration significant, new class bioadhesive.

Язык: Английский

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Nanoemulsion-Based Technologies for Delivering Natural Plant-Based Antimicrobials in Foods

Frontiers in Sustainable Food Systems, Год журнала: 2021, Номер 5

Опубликована: Фев. 18, 2021

There is increasing interest in the use of natural preservatives (rather than synthetic ones) for maintaining quality and safety foods due to their perceived environmental health benefits. In particular, plant-based antimicrobials are being employed protect against microbial spoilage, thereby improving food safety, quality, shelf-life. However, many cannot be utilized free form chemical instability, poor dispersibility matrices, or unacceptable flavor profiles. For these reasons, encapsulation technologies, such as nanoemulsions, developed overcome hurdles. Indeed, can improve handling ease use, well enhance potency. This review highlights various kinds that available applications. It then describes methods forming nanoemulsions shows how they used encapsulate deliver preservatives. Finally, potential applications nano-emulsified demonstrated meat, fish, dairy, fresh produce areas.

Язык: Английский

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Bioinspired Polyacrylic Acid‐Based Dressing: Wet Adhesive, Self‐Healing, and Multi‐Biofunctional Coacervate Hydrogel Accelerates Wound Healing

Advanced Science, Год журнала: 2023, Номер 10(16)

Опубликована: Апрель 14, 2023

Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong capability is fabricated through facile mixture of PAA copolymers isoprenyl oxy poly(ethylene glycol) ether tannic (TA). The segments on prevent electrostatic repulsion among ionized carboxyl groups absorbed TA to form coacervates. provides solid dry substrates via multifarious interactions, which endows an adhesive strength skin 23.4 kPa 70% underwater. This achieves desirable self-healing extensible properties suitable for frequently moving joints. These investigations prove that has antibacterial activity, facilitates fibroblast migration, modulates M1/M2 polarization macrophages. In vivo hemorrhage experiments further confirm dramatically shortens hemostatic time from hundreds tens seconds. addition, full-thickness defect demonstrate best therapeutic effect by significantly promoting collagen deposition, angiogenesis, epithelialization. results promising dressing medical translation.

Язык: Английский

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Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Antibiotics, Год журнала: 2022, Номер 11(6), С. 766 - 766

Опубликована: Июнь 2, 2022

The overuse and misuse of antibiotics has contributed to the rise spread multidrug-resistant bacteria. To address this global public health threat, many countries have restricted use as growth promoters promoted development alternatives in human veterinary medicine animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, antimicrobial peptides shown hallmarks antibiotics. This review reports current state these growth-promoting factors for poultry swine production describes their mode action. Recent findings on usefulness that presently hinder broader food are identified by SWOT (strength, weakness, opportunity, threat) analysis. potential resistance well co- cross-resistance with currently used is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web Science, Google Scholar. Antibiotic cannot be stopped, but its spreading can certainly hindered or delayed more innovative modes action a wise careful antimicrobials One Health approach.

Язык: Английский

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Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS

Life, Год журнала: 2023, Номер 13(3), С. 735 - 735

Опубликована: Март 9, 2023

Zivzik pomegranate (Punica granatum) has recently sparked considerable interest due to its nutritional and antioxidant properties. To evaluate the capacities of P. granatum juice, ethanol (EEZP), water (WEZP) extracts from peel seed, methods 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) scavenging, 1,1-diphenyl-2-picrylhydrazyl free (DPPH•) Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) reducing, Fe3+ Cu2+ reducing were used. The samples compared with most commonly used synthetic antioxidants, i.e., BHA, BHT, α-tocopherol, Trolox. In terms setting an example, IC50 values EEZP for ABTS•+ DPPH• scavenging activities found be lower than standards, at 5.9 16.1 μg/mL, respectively. phenolic flavonoid contents in 59.7 mg GAE/g 88.0 QE/g, Inhibition α-glycosidase, α-amylase, acetylcholinesterase, human carbonic anhydrase II (hCA II) enzymes was also investigated. demonstrated 7.3 μg/mL against 317.7 19.7 acetylcholinesterase (AChE), 106.3 CA enzymes. A total 53 compounds scanned, 30 determined using LC-MS/MS. E. coli S. aureus bacteria resistant all four antibiotics as standards hospitals.

Язык: Английский

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pH-Responsive wound dressings: advances and prospects

Nanoscale Horizons, Год журнала: 2023, Номер 8(4), С. 422 - 440

Опубликована: Янв. 1, 2023

This review focuses on the design strategies and advanced functions of pH-responsive wound dressings, makes a systematic discussion challenges future development trends in this field.

Язык: Английский

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Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

Carbohydrate Polymers, Год журнала: 2022, Номер 295, С. 119844 - 119844

Опубликована: Июль 9, 2022

Язык: Английский

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