Molecules,
Год журнала:
2023,
Номер
28(19), С. 6918 - 6918
Опубликована: Окт. 3, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
syndrome.
The
prevalence
of
NAFLD
has
continued
to
increase
globally,
and
become
worldwide
public
health
problem.
Glucosamine
(GLC)
an
amino
monosaccharide
derivative
glucose.
GLC
been
proven
not
only
be
effective
in
anti-inflammation
applications,
but
also
modulate
the
gut
microbiota
effectively.
Therefore,
this
study,
therapeutic
effect
context
mechanisms
underlying
these
effects
were
explored.
Specifically,
model
was
established
by
feeding
mice
high-fat
high-sugar
diet
(HFHSD),
HFHSD-fed
treated
with
GLC.
First,
we
investigated
treating
analyzing
serum-
liver-related
indicator
levels.
We
found
that
attenuated
insulin
resistance
inflammation,
increased
antioxidant
function,
serum
lipid
metabolism
mice.
Then,
mechanism
metabolism,
intestinal
barrier
function
can
improve
relieve
oxidative
stress
In
addition,
treatment
reduced
LPS
translocation,
inflammation
inhibiting
activation
LPS/TLR4/NF-κB
pathway,
thereby
effectively
ameliorating
lesions
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(2), С. 932 - 945
Опубликована: Янв. 26, 2024
Periodontitis
is
a
bacterially
induced
chronic
destructive
inflammatory
disease
that
leads
to
irreversible
destruction
of
the
tooth
supporting
structure,
including
connective
tissue
destruction,
bone
resorption,
and
even
loss.
Until
now,
there
has
been
no
effective
treatment
repair
loss
in
periodontitis.
Recently,
small
extracellular
vesicles
(sEVs)
emerged
as
essential
paracrine
factors
mesenchymal
stem
cells
(MSCs)
mediated
regeneration.
However,
limitations
antimicrobial
activity
associated
with
use
sEVs
have
led
urgency
new
alternative
strategies.
Currently,
we
investigated
potential
biocompatible
oxygen-releasing
thermosensitive
hydrogel
laded
secreted
by
marrow
MSCs
(BMMSCs)
for
alveolar
defect
The
composed
different
polymers
such
chitosan
(CS),
poloxamer
407
(P407),
cross-linked
hyaluronic
acid
(c-HA)
conglomerating
kind
nanoporous
structure
material.
Then,
gel
matrix
further
encapsulated
calcium
peroxide
nanoparticles
realize
control
oxygen
release.
Furthermore,
ascorbic
was
added
achieve
REDOX
equilibrium
acid–base
equilibrium.
experiments
vivo
vitro
proved
its
good
biocompatibility
effectively
inhibited
growth
periodontal
main
anaerobe,
relieved
pocket
anaerobic
infections,
promoted
Therefore,
this
finding
demonstrated
it
promising
approach
combating
pathogens
enhanced
selective
properties
diseases,
other
bacteria-induced
future
clinical
application.
Arabian Journal for Science and Engineering,
Год журнала:
2023,
Номер
48(6), С. 7587 - 7601
Опубликована: Янв. 12, 2023
Abstract
This
study
intends
to
develop
a
novel
bioactive
chitosan
Schiff
base
(CTS-SB)
derivative
via
coupling
of
(CTS)
with
4-((5,
5-dimethyl-3-oxocyclohex-1-en-1-yl)
amino)
benzene-sulfonamide.
The
alteration
in
the
chemical
structure
CTS-SB
was
verified
using
1
H
NMR
and
FT-IR
analysis,
while
thermal
morphological
properties
were
inspected
by
TGA
SEM
characterization
tools,
respectively.
Ion
exchange
capacity
developed
recorded
maximal
value
12.1
meq/g
compared
10.1
for
pristine
CTS.
In
addition,
antibacterial
activity
greatly
boosted
against
Escherichia
coli
(
E
)
Staphylococcus
aureus
S.
bacteria.
Minimum
inhibition
concentration
perceived
at
50
µg/mL,
highest
(250
µg/mL)
could
inhibit
growth
up
91%.
What’s
more,
enhanced
antidiabetic
derivative,
which
displayed
higher
inhibitory
values
α-amylase
(57.9%)
α-glucosidase
(63.9%),
those
pure
CTS
(49.8
53.4%),
respectively
Furthermore,
cytotoxicity
investigation
on
HepG-2
cell
line
revealed
potential
anticancer
along
good
safety
margin
primary
human
skin
fibroblasts
(HSF
cells)
decent
cytocompatibility.
Collectively,
gained
results
hypothesized
that
be
effectively
applied
as
promising
antibacterial,
agent
advanced
biomedical
applications.
Carbohydrate Polymers,
Год журнала:
2023,
Номер
316, С. 120999 - 120999
Опубликована: Май 10, 2023
Physically-induced
depolymerisation
procedures
are
often
preferred
for
obtaining
alginate
and
chitosan
oligosaccharides
as
they
either
do
not
use
or
make
minimal
of
additional
chemicals;
therefore,
separation
the
final
products
is
facile.
In
this
work,
solutions
three
types
with
different
mannuronic
guluronic
acid
residues
ratio
(M/G
ratio)
molecular
weights
(Mw)
one
type
were
non-thermally
processed
by
applying
high
hydrostatic
pressures
(HHP)
up
to
500
MPa
(20
min)
pulsed
electric
fields
(PEF)
25
kV
cm-1
(4000
μm)
in
absence
presence
3
%
hydrogen
peroxide
(H2O2).
The
impact
on
physicochemical
properties
was
investigated
rheology,
GPC,
XRD,
FTIR,
1H
NMR.
rheological
investigations,
apparent
viscosities
all
samples
decreased
increasing
shear
rate,
indicating
a
non-Newtonian
shear-thinning
behaviour.
GPC
results
reported
Mw
reductions
that
ranged
between
8
96
treatments.
NMR
revealed
HHP
PEF
treatment
predominantly
reduced
M/G
degree
deacetylation
(DDA)
chitosan,
whilst
H2O2
promoted
an
increase
DDA
chitosan.
Overall,
present
investigation
has
demonstrated
feasibility
rapidly
producing
oligosaccharides.
Foods,
Год журнала:
2023,
Номер
12(3), С. 634 - 634
Опубликована: Фев. 2, 2023
The
antibacterial
effect
of
chitooligosaccharide
conjugated
with
five
different
polyphenols,
including
catechin
(COS-CAT),
epigallocatechin
gallate
(COS-EGCG),
gallic
acid
(COS-GAL),
caffeic
(COS-CAF),
and
ferulic
(COS-FER),
against
Listeria
monocytogenes
was
investigated.
Among
all
the
conjugates
tested,
COS-EGCG
showed
highest
inhibition
toward
monocytogenes,
a
minimum
inhibitory
concentration
(MIC)
bactericidal
(MBC)
1024
µg/mL,
respectively.
conjugate
also
had
on
environmental
clinical
strains
L.
monocytogenes.
low
augmented
formation
biofilm
growth
Nevertheless,
bacterial
achieved
when
treated
at
2
×
MIC
for
48
h.
In
addition,
potential
to
inactivate
pre-biofilm,
it
reduced
production
extracellular
polysaccharides
MIC/4
effectively
impeded
motility
(the
swimming
swarming)
an
85.7–94.3%
inhibition,
while
100%
MIC.
Based
scanning
electron
microscopic
(SEM)
images,
cell
wall
damage
numerous
pores
surface
observed.
Such
distortion
resulted
in
protein
leakage.
As
result,
could
penetrate
into
bind
DNA
backbone.
Therefore,
be
further
developed
as
natural
antimicrobial
agent
inhibiting
or
controlling
