Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Polymers, Год журнала: 2024, Номер 16(10), С. 1351 - 1351

Опубликована: Май 10, 2024

Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse chitosan derivatives antibacterial, anticancer, wound healing, tissue engineering fields. In antibacterial applications, exhibits potent antimicrobial properties by disrupting microbial membranes DNA, making it promising natural preservative agent against bacterial infections. Its role cancer therapy involves development chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays crucial healing promoting cell proliferation, angiogenesis, regulating inflammatory responses. Additionally, serves multifunctional scaffold engineering, facilitating regeneration tissues cartilage, bone, neural adhesion proliferation. The extensive range pharmaceutical sciences is not only highlighted comprehensive scope this review, but establishes fundamental component forthcoming research biomedicine.

Язык: Английский

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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules, Год журнала: 2025, Номер 30(2), С. 207 - 207

Опубликована: Янв. 7, 2025

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.

Язык: Английский

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Medicinal and chemosensing applications of chitosan based material: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131493 - 131493

Опубликована: Апрель 11, 2024

Язык: Английский

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Synthesis, Spectral Characterization, Thermal Investigation, Computational Studies, Molecular Docking, and In Vitro Biological Activities of a New Schiff Base Derived from 2-Chloro Benzaldehyde and 3,3′-Dimethyl-[1,1′-biphenyl]-4,4′-diamine

ACS Omega, Год журнала: 2023, Номер 8(36), С. 33069 - 33082

Опубликована: Авг. 25, 2023

The current research involves the synthesis of a new Schiff base through reaction between 2-chlorobenzaldehyde and 3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diamine by using natural acid catalyst synthesized compound physicochemically characterized X-ray diffraction, Fourier transform infrared spectroscopy, 1H- 13C-nuclear magnetic resonance, liquid chromatography-mass spectrometry. Thermal studies were conducted thermogravimetric, differential thermal analysis, thermogravimetric curves. These curves obtained in an inert nitrogen environment from ambient temperature to 1263 K heating rates 10, 15, 20 K·min-1. Using thermocurve data, model-free isoconversional techniques such as Kissinger-Akahira-Sunose, Flynn-Wall-Ozawa, Friedman are used determine kinetic parameters. parameters include activation energy, phonon frequency factor, enthalpy, entropy, Gibb's free energy change. All results have been thoroughly investigated. molecule's anti-inflammatory antidiabetic properties also examined. To learn more about potential how successfully it can suppress amylase enzyme, molecular docking experiment was conducted. For silico research, Swiss Absorption, Distribution, Metabolism, Excretion, Toxicity algorithms calculate theoretical pharmacokinetic properties, oral bioavailability, toxic effects, biological activities molecule. Moreover, cytotoxicity tests against human lung cancer cell line (A549) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay demonstrated that exhibited significant anticancer properties.

Язык: Английский

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Sulfamethoxazole-derived Schiff bases: Synthesis, characterization, biological activities, molecular docking, DFT, and ADME studies

Journal of Molecular Structure, Год журнала: 2024, Номер 1312, С. 138640 - 138640

Опубликована: Май 15, 2024

Язык: Английский

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Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Inorganics, Год журнала: 2023, Номер 11(8), С. 320 - 320

Опубликована: Июль 28, 2023

Complexes of Schiff bases (SBs) with metals are promising compounds exhibiting a broad range applications, such as catalysts, polymers, dyes, and several biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, antidiabetic actions. Considering the crisis that whole world is now facing against antimicrobial-resistant bacteria, in present review, we chose to focus on activity SBs antimicrobials, particularly underlying most recent studies this field. Finally, some interesting catalytic applications recently described for metal complexes have also been discussed.

Язык: Английский

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Strategies for the Preparation of Chitosan Derivatives for Antimicrobial, Drug Delivery, and Agricultural Applications: A Review

Molecules, Год журнала: 2023, Номер 28(22), С. 7659 - 7659

Опубликована: Ноя. 18, 2023

Chitosan has received much attention for its role in designing and developing novel derivatives as well applications across a broad spectrum of biological physiological activities, owing to desirable characteristics such being biodegradable, biopolymer, overall eco-friendliness. The main objective this review is explore the recent chemical modifications chitosan that have been achieved through various synthetic methods. These are categorized based on their pathways or presence common functional groups, which include alkylated, acylated, Schiff base, quaternary ammonia, guanidine, heterocyclic rings. We also described derivatives, along with nanomaterials, mechanisms, prospective challenges, especially areas antimicrobial targeted drug delivery diseases, plant agricultural domains. accumulation these findings potential offer insight not only into innovative approaches preparation but diverse applications. insights may spark ideas development carriers, particularly antimicrobial, medicinal, fields.

Язык: Английский

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Palm Fruit (Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage

Nutrients, Год журнала: 2023, Номер 15(11), С. 2614 - 2614

Опубликована: Июнь 2, 2023

Palm fruit pollen extract (PFPE) is a natural source of bioactive polyphenols. The primary aim the study was to determine antioxidant, antimicrobial, anticancer, enzyme inhibition, bovine serum albumin (BSA), and DNA-protective properties PFPE identify quantify phenolic compounds present in PFPE. results demonstrated that exhibited potent antioxidant activity various radical-scavenging assays, including (2,2-diphenyl-1-picrylhydrazyl) (DPPH

Язык: Английский

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Fabrication and characterization of a new eco-friendly sulfonamide-chitosan derivative with enhanced antimicrobial and selective cytotoxicity properties

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 3, 2024

Abstract Chitosan (CH) exhibits low antimicrobial activity. This study addresses this issue by modifying the chitosan with a sulfonamide derivative, 3-(4-(N,N-dimethylsulfonyl)phenyl)acrylic acid. The structure of sulfonamide-chitosan derivative (DMS-CH) was confirmed using Fourier transform infrared spectroscopy and Nuclear magnetic resonance. results scanning electron microscopy, thermal gravimetric analysis, X-ray diffraction indicated that morphology changed to porous nature, stability decreased, crystallinity increased in DMS-CH compared chitosan, respectively. degree substitution calculated from elemental analysis data found be moderate (42%). modified exhibited enhanced properties at concentrations, minimum inhibitory concentration (MIC) 50 µg/mL observed for B. subtilis P. aeruginosa , value 25 S. aureus E. coli C. albicans . In case native MIC values doubled or more, recorded 100 μg/mL Furthermore, toxicological examinations conducted on MCF-7 (breast adenocarcinoma) cell lines demonstrated greater toxicity (IC50 = 225.47 μg/mL) than pure CH, while still maintaining significant safety limits against normal lung fibroblasts (WI-38). Collectively, these suggest potential use newly biomedical applications.

Язык: Английский

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Exploring New Schiff Bases: Synthesis, Characterization, and Multifaceted Analysis for Biomedical Applications

ACS Omega, Год журнала: 2024, Номер 9(33), С. 35431 - 35448

Опубликована: Июнь 24, 2024

The current work aims to generate novel Schiff bases by reacting substituted aldehydes with amine derivatives catalyzed a natural acid. developed compounds underwent diverse physicochemical analyses including liquid chromatography-mass spectrometry, Fourier transform infrared spectroscopy, scanning electron microscopy,

Язык: Английский

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